Imperial College London
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Dr Simon C. Cork, PhD, FHEA

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Lecturer
 
 
 
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Contact

 

+44 (0)20 7848 8044simon.cork

 
 
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Location

 

Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cork:2018:10.1111/jne.12643,
author = {Cork, SC},
doi = {10.1111/jne.12643},
journal = {Journal of Neuroendocrinology},
title = {The role of the vagus nerve in appetite control: implications for the pathogenesis of obesity},
url = {http://dx.doi.org/10.1111/jne.12643},
volume = {30},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The communication between the gut and the brain is important for the control of energy homeostasis. In response to food intake, enteroendocrine cells secrete gut hormones which ultimately suppress appetite through centrally-mediated processes. Increasing evidence implicates the vagus nerve as an important conduit in transmitting these signals from the gastrointestinal tract to the brain. Studies have demonstrated that many of the gut hormones secreted from enteroendocrine cells signal through the vagus nerve, and the sensitivity of the vagus to these signals is regulated by feeding status. Furthermore, evidence suggests that a reduction in the ability of the vagus nerve to respond to the switch between a "fasted" and "fed" state, retaining sensitivity to orexigenic signals when fed or a reduced ability to respond to satiety hormones, may contribute to obesity. This article is protected by copyright. All rights reserved.
AU  - Cork,SC
DO  - 10.1111/jne.12643
PY  - 2018///
SN  - 0953-8194
TI  - The role of the vagus nerve in appetite control: implications for the pathogenesis of obesity
T2  - Journal of Neuroendocrinology
UR  - http://dx.doi.org/10.1111/jne.12643
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30203877
UR  - http://hdl.handle.net/10044/1/64472
VL  - 30
ER  -
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