Imperial College London

Prof Sonia Dagnino

Faculty of MedicineSchool of Public Health

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 2067sonia.dagnino

 
 
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Location

 

512Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

41 results found

Marchiandi J, Alghamdi W, Dagnino S, Green MP, Clarke BOet al., 2024, Exposure to endocrine disrupting chemicals from beverage packaging materials and risk assessment for consumers., J Hazard Mater, Vol: 465

This study investigated the influence of beverage packaging materials on the presence of endocrine disrupting chemicals (EDCs) in plastic, glass, carton, aluminium, and tin canned non-alcoholic beverages. Results showed that 63 EDCs including perfluoroalkyl and polyfluoroalkyl substances (PFAS), bisphenols, parabens, benzophenone-type UV-filters, biocides, nitrophenols, and alkylphenols, were detected in 144/162 screened products. Detected ∑63EDC concentrations ranged from 1.3 to 19,600 ng/L. EDC concentrations were higher in beverages packaged in metal cans while lower or no levels were detected in glass, plastic, and carton packaged drinks. Bisphenol levels were higher on average in canned beverages compared to glass (p < 0.01) and plastic products (p < 0.05) produced by the same brand and manufacturer. Two structural isomers of bisphenol A (BPA) were identified in 19 beverages, constituting the first detection in foodstuffs. The calculated daily intake of detected EDCs showed that exposure to BPA from per capita beverage consumption of 364 mL/day are up to 2000-fold higher than the newly revised safety guideline for BPA recommended by the EFSA (European Food Safety Authority). Overall, these findings suggest that BPA exposure poses a potential health hazard for individuals who regularly consume non-alcoholic beverages packaged in aluminium or tin cans, particularly young children.

Journal article

Alcolea J, Donat-Vargas C, Chrysovalantou Chatziioannou A, Keski-Rahkonen P, Robinot N, Molina AJ, Amiano P, Gómez-Acebo I, Castaño-Vinyals G, Maitre L, Chadeau M, Dagnino S, Cheng S, Scalbert A, Vineis P, Kogevinas M, Villanueva Cet al., 2023, Metabolomic signatures of exposure to nitrate and trihalomethanes in drinking water and colorectal cancer risk in a Spanish multicentric study (MCC-Spain), Environmental Science and Technology (Washington), Vol: 57, Pages: 19316-19329, ISSN: 0013-936X

We investigated the metabolomic profile associated with exposure to trihalomethanes (THMs)and nitrate in drinking water, and with colorectal cancer risk in 296 cases and 295 controlsfrom the Multi Case-Control Spain project. Untargeted metabolomic analysis was conductedin blood samples using ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry. A variety of univariate and multivariate association analyses wereconducted after data quality control, normalization and imputation. Linear regression andpartial least square analyses were conducted for chloroform, brominated THMs, total THMs,and nitrate among controls, and for case-control status, together with a N-integration modeldiscriminating colorectal cancer cases from controls through interrogation of correlationsbetween the exposure variables and the metabolomic features. Results revealed a total of 568metabolomic features associated with at least one water contaminant or colorectal cancer.Annotated metabolites and pathway analysis suggest a number of pathways as potentiallyinvolved in the link between exposure to these water contaminants and colorectal cancer,including nicotinamide, cytochrome P-450, and tyrosine metabolism. These findings provideinsights into the underlying biological mechanisms and potential biomarkers associated withwater contaminants exposure and colorectal cancer risk. Further research in this area isneeded to better understand the causal relationship and public health implications.

Journal article

Segrado F, Cavalleri A, Cantalupi A, Mariani L, Dagnino S, Krogh V, Venturelli E, Agnoli Cet al., 2022, A software-assisted untargeted liquid chromatography-mass spectrometry method for lipidomic profiling of human plasma samples, INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS, Vol: 37, Pages: 368-376, ISSN: 0393-6155

Journal article

Petrovic D, Bodinier B, Dagnino S, Whitaker M, Karimi M, Campanella G, Haugdahl Nøst T, Polidoro S, Palli D, Krogh V, Tumino R, Sacerdote C, Panico S, Lund E, Dugue PA, Giles G, Severi G, Southey M, Vineis P, Stringhini S, Bochud M, Sandanger T, Vermeulen R, Guida F, Chadeau Met al., 2022, Epigenetic mechanisms of lung carcinogenesis involve differentially methylated CpG sites beyond those associated with smoking, European Journal of Epidemiology, Vol: 37, Pages: 629-640, ISSN: 0393-2990

Smoking-related epigenetic changes have been linked to lung cancer, but the contribution of epigenetic alterations unrelated to smoking remains unclear. We sought for a sparse set of CpG sites predicting lung cancer and explored the role of smoking in these associations. We analysed CpGs in relation to lung cancer in participants from two nested case–control studies, using (LASSO)-penalised regression. We accounted for the effects of smoking using known smoking-related CpGs, and through conditional-independence network. We identified 29 CpGs (8 smoking-related, 21 smoking-unrelated) associated with lung cancer. Models additionally adjusted for Comprehensive Smoking Index-(CSI) selected 1 smoking-related and 49 smoking-unrelated CpGs. Selected CpGs yielded excellent discriminatory performances, outperforming information provided by CSI only. Of the 8 selected smoking-related CpGs, two captured lung cancer-relevant effects of smoking that were missed by CSI. Further, the 50 CpGs identified in the CSI-adjusted model complementarily explained lung cancer risk. These markers may provide further insight into lung cancer carcinogenesis and help improving early identification of high-risk patients.

Journal article

Marchiandi J, Szabo D, Dagnino S, Green MP, Clarke BOet al., 2021, Occurrence and fate of legacy and novel per- and polyfluoroalkyl substances (PFASs) in freshwater after an industrial fire of unknown chemical stockpiles, ENVIRONMENTAL POLLUTION, Vol: 278, ISSN: 0269-7491

Journal article

Torrino S, Tiroille V, Dolfi B, Dufies M, Hinault C, Bonesso L, Dagnino S, Uhler J, Irondelle M, Gay A-S, Fleuriot L, Debayle D, Lacas-Gervais S, Cormont M, Bertero T, Bost F, Gilleron J, Clavel Set al., 2021, UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling, ELIFE, Vol: 10, ISSN: 2050-084X

Journal article

Dagnino S, Bodinier B, Guida F, Smith-Byrne K, Petrovic D, Whitaker M, Haugdahl T, Agnoli C, Palli D, Sacerdote C, Panico S, Tumino R, Schulze M, Johansson M, Keski-Rahkonen P, Scalbert A, Vineis P, Mattias J, Sandanger T, Vermeulen R, Chadeau Met al., 2021, Prospective identification of elevated circulating CDCP1 in patients years before onset of lung cancer, Cancer Research, Vol: 81, ISSN: 0008-5472

Increasing evidence points to a role for inflammation in lung carcinogenesis. A small number of circulating inflammatory proteins have been identified as showing elevated levels prior to lung cancer diagnosis, indicating the potential for prospective circulating protein concentration as a marker of early carcinogenesis. In order to identify novel markers of lung cancer risk, we measured a panel of 92 circulating inflammatory proteins in 648 pre-diagnostic blood samples from two prospective cohorts in Italy and Norway (women only). To preserve the comparability of results and protect against confounding factors, the main statistical analyses were conducted in women from both studies, with replication sought in men (Italian participants). Univariate and penalized regression models revealed for the first time higher blood levels of CDCP1 protein in cases that went on to develop lung cancer compared to controls, irrespective of time to diagnosis, smoking habits, and gender. This association was validated in an additional 450 samples. Associations were stronger for future cases of adenocarcinoma where CDCP1 showed better explanatory performance. Integrative analyses combining gene expression and protein levels CDCP1 measured in the same individuals suggested a link between CDCP1 and the expression of transcripts of LRRN3 and SEM1. Enrichment analyses indicated a potential role for CDCP1 in pathways related to cell adhesion and mobility, such as the WNT/β-catenin pathway. Overall, this study identifies lung cancer-related dysregulation of CDCP1 expression years before diagnosis.

Journal article

Vineis P, Chadeau M, Dagnino S, Mudway I, Robinson O, Dehghan Aet al., 2020, What's new in the Exposome?, Environment International, Vol: 143, Pages: 1-13, ISSN: 0160-4120

The exposome concept refers to the totality of exposures from a variety of external and internal sources including chemical agents, biological agents, or radiation, from conception onward, over a complete lifetime. It encompasses also “psychosocial components” including the impact of social relations and socio-economic position on health. In this review we provide examples of recent contributions from exposome research, where we believe their application will be of the greatest value for moving forward. So far, environmental epidemiology has mainly focused on hard outcomes, such as mortality, disease exacerbation and hospitalizations. However, there are many subtle outcomes that can be related to environmental exposures, and investigations can be facilitated by an improved understanding of internal biomarkers of exposure and response, through the application of omic technologies. Second, though we have a wealth of studies on environmental pollutants, the assessment of causality is often difficult because of confounding, reverse causation and other uncertainties. Biomarkers and omic technologies may allow better causal attribution, for example using instrumental variables in triangulation, as we discuss here. Even more complex is the understanding of how social relationships (in particular socio-economic differences) influence health and imprint on the fundamental biology of the individual. The identification of molecular changes that are intermediate between social determinants and disease status is a way to fill the gap. Another field in which biomarkers and omics are relevant is the study of mixtures. Epidemiology often deals with complex mixtures (e.g. ambient air pollution, food, smoking) without fully disentangling the compositional complexity of the mixture, or with rudimentary approaches to reflect the overall effect of multiple exposures or components.From the point of view of disease mechanisms, most models hypothesize that several stages need t

Journal article

Dagnino S, Bodinier B, Grigoryan H, Rappaport S, Karimi M, Guida F, Polidoro S, Edmands W, Naccarati A, GFiorito G, Sacerdote C, Krogh V, Vermeulen R, Vineis P, Chadeau Met al., 2020, Agnostic Cys34-albumin adductomics and DNA methylation: implication of Nacetylcysteine in lung carcinogenesis years before diagnosis, International Journal of Cancer, Vol: 146, Pages: 3294-3303, ISSN: 0020-7136

Although smoking and oxidative stress are known contributors to lung carcinogenesis, theirmechanisms of action remain poorly understood. To shed light into these mechanisms, weapplied a novel approach using Cys34-adductomics in a lung cancer nested case-controlstudy (n=212). Adductomics profiles were integrated with DNA-methylation data atestablished smoking-related CpG sites measured in the same individuals. Our analysisidentified 42 Cys34-albumin adducts, of which 2 were significantly differentially abundant incases and controls: adduct of N-acetylcysteine (NAC, p=4.15x10-3) and of Cysteinyl-Glycine(Cys-Gly, p=7.89x10-3). Blood levels of the former were found associated to the methylationlevels at 11 smoking related CpG sites. We detect, for the first time in prospective bloodsamples, and irrespective of time-to-diagnosis, decreased levels of NAC adduct in lungcancer cases. Altogether, our results highlight the potential role of these adducts in theoxidative stress response contributing to lung carcinogenesis years before diagnosis.

Journal article

Marchiandi J, Green MP, Dagnino S, Anumol T, Clarke BOet al., 2020, Characterising the effects of per- and polyfluoroalkyl substances (PFASs) on health and disease: An opportunity for exposomics?, CURRENT OPINION IN ENVIRONMENTAL SCIENCE & HEALTH, Vol: 15, Pages: 39-48, ISSN: 2468-5844

Journal article

Torrino S, Tiroille V, Dolfi B, Dufies M, Hinault C, Bonesso L, Dagnino S, Uhler JP, Irondelle M, Gay AS, Fleuriot L, Debayle D, Lacas-Gervais S, Cormont M, Bertero T, Bost F, Gilleron J, Clavel Set al., 2020, UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling

<jats:title>Abstract</jats:title><jats:p>To adapt in an ever-changing environment, cells must integrate physical and chemical signals and translate them into biological meaningful information through complex signaling pathways. By combining lipidomic and proteomic approaches with functional analysis, we have shown that UBTD1 (Ubiquitin domain-containing protein 1) plays a crucial role in both the EGFR (Epidermal Growth Factor Receptor) self-phosphorylation and its lysosomal degradation. On the one hand, by modulating the cellular level of ceramides through ASAH1 (N-Acylsphingosine Amidohydrolase 1) ubiquitination, UBTD1 controls the ligand-independent phosphorylation of EGFR. On the other hand, UBTD1, <jats:italic>via</jats:italic> the ubiquitination of SQSTM1/p62 (Sequestosome 1) and endolysosome positioning, participates in the lysosomal degradation of EGFR. The coordination of these two ubiquitin-dependent processes contributes to the control of the duration of the EGFR signal. Moreover, we showed that UBTD1 depletion exacerbates EGFR signaling and induces cell proliferation emphasizing a <jats:italic>hitherto</jats:italic> unknown function of UBTD1 in EGF-driven cell proliferation.</jats:p>

Journal article

Preston GW, Dagnino S, Ponzi E, Sozeri O, van Veldhoven K, Barratt B, Liu S, Grigoryan H, Lu SS, Rappaport SM, Chung KF, Cullinan P, Sinharay R, Kelly FJ, Chadeau-Hyam M, Vineis P, Phillips DHet al., 2020, Relationships between airborne pollutants, serum albumin adducts and short-term health outcomes in an experimental crossover study, Chemosphere, Vol: 239, ISSN: 1879-1298

Exposure to air pollution can have both short-term and long-term effects on health. However, the relationships between specific pollutants and their effects can be obscured by characteristics of both the pollution and the exposed population. One way of elucidating the relationships is to link exposures and internal changes at the level of the individual. To this end, we combined personal exposure monitoring (59 individuals, Oxford Street II crossover study) with mass-spectrometry-based analyses of putative serum albumin adducts (fixed-step selected reaction monitoring). We attempted to infer adducts' identities using data from another, higher-resolution mass spectrometry method, and were able to detect a semi-synthetic standard with both methods. A generalised least squares regression method was used to test for associations between amounts of adducts and pollution measures (ambient concentrations of nitrogen dioxide and particulate matter), and between amounts of adducts and short-term health outcomes (measures of lung health and arterial stiffness). Amounts of some putative adducts (e.g., one with a positive mass shift of approximately 143Da) were associated with exposure to pollution (11 associations), and amounts of other adducts were associated with health outcomes (eight associations). Adducts did not appear to provide a link between exposures and short-term health outcomes.

Journal article

Grigoryan H, Schiffman C, Gunter MJ, Naccarati A, Polidoro S, Dagnino S, Dudoit S, Vineis P, Rappaport SMet al., 2019, Cys34 Adductomics Links Colorectal Cancer with the Gut Microbiota and Redox Biology, CANCER RESEARCH, Vol: 79, Pages: 6024-6031, ISSN: 0008-5472

Journal article

Dagnino S, Macherone A, 2018, Unraveling the exposome: A practical view, ISBN: 9783319893204

This volume presents a comprehensive overview of the science and application of the Exposome through seventeen chapters from leaders in the field. At just over ten years since the term was coined by Christopher Wild in 2005, this is the first, field-defining volume to offer a holistic picture of the important and growing field of Exposomics. The term "Exposome" describes the sum of all exposures (not only chemical) that an individual can receive over a lifetime from both exogenous sources (environmental contaminants, food, lifestyle, drugs, air, etc.) and endogenous sources (metabolism, oxidative stress, lipid peroxidation, chemicals synthesized by the microbiome, etc.). The first section of this book contains chapters that discuss how the Exposome is defined and how the concept fits into the fields of public health and epidemiology. The second section provides an overview of techniques and methods to measure the human Exposome. The third section contains methods and applications for measuring the Exposome through external exposures. Section four provides an overview on statistical and computational techniques- including big data analysis - for characterizing the Exposome. Section five presents a global collection of case studies.

Book

Dagnino S, 2018, Unravelling the exposome: Conclusions and thoughts for the future, Unravelling the Exposome, Editors: Dagnino, Macherone, Publisher: Springer, Pages: 425-437

Since it was first defined by Christopher Wild, to today, the concept of the exposome has evolved into a valuable tool to evaluate human exposure and health. In the chapters of this book the definition of the exposome paradigm and concept is discussed. The most recent techniques based on OMICs, targeted and untargeted analysis for its characterization are described. The challenges arising from the amount of data that needs to be processed to understand the complex mechanism behind exposure and health outcome, as well as the latest statistical and data analysis methods have been discussed. Finally, multiple projects across the globe have or are currently tackling the application of the exposome concept to real studies, and these studies have been presented in this book. In this section, we will provide a chapter summary, and describe how the exposome paradigm has advanced since its definition. We will also explore question such as: what have we learned so far? Does the exposome paradigm provide valuable information? And what needs to be improved? Finally, we will discuss the possibility of future applications of the exposome in disease causality and personalized medicine.

Book chapter

Bieber S, Snyder SA, Dagnino S, Rauch-Williams T, Drewes JEet al., 2018, Management strategies for trace organic chemicals in water - A review of international approaches, CHEMOSPHERE, Vol: 195, Pages: 410-426, ISSN: 0045-6535

Journal article

Liu S, Grigoryan H, Edmands WMB, Dagnino S, Sinharay R, Cullinan P, Collins P, Chung KF, Barratt B, Kelly F, Vineis P, Rappaport SMet al., 2018, Cys34 Adductomes Differ between Patients with Chronic Lung or Heart Disease and Healthy Controls in Central London, Environmental Science and Technology (Washington), Vol: 52, Pages: 2307-2313, ISSN: 0013-936X

Oxidative stress generates reactive species that modify proteins, deplete antioxidant defenses, and contribute to chronic obstructive pulmonary disease (COPD) and ischemic heart disease (IHD). To determine whether protein modifications differ between COPD or IHD patients and healthy subjects, we performed untargeted analysis of adducts at the Cys34 locus of human serum albumin (HSA). Biospecimens were obtained from nonsmoking participants from London, U.K., including healthy subjects (n = 20) and patients with COPD (n = 20) or IHD (n = 10). Serum samples were digested with trypsin and analyzed by liquid chromatography-high resolution mass spectrometry. Effects of air pollution on adduct levels were also investigated based on estimated residential exposures to PM2.5, O3 and NO2. For the 39 adducts with sufficient data, levels were essentially identical in blood samples collected from the same subjects on two consecutive days, consistent with the 28 day residence time of HSA. Multivariate linear regression revealed 21 significant associations, mainly with the underlying diseases but also with air-pollution exposures (p-value < 0.05). Interestingly, most of the associations indicated that adduct levels decreased with the presence of disease or increased pollutant concentrations. Negative associations of COPD and IHD with the Cys34 disulfide of glutathione and two Cys34 sulfoxidations, were consistent with previous results from smoking and nonsmoking volunteers and nonsmoking women exposed to indoor combustion of coal and wood.

Journal article

Rushing BR, Hu Q, Franklin JN, McMahen R, Dagnino S, Higgins CP, Strynar MJ, DeWitt JCet al., 2017, Evaluation of the immunomodulatory effects of 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate in C57BL/6 mice., Toxicological Sciences, Vol: 156, Pages: 179-189, ISSN: 1096-6080

2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate was designed to replace perfluorooctanoic acid (PFOA), which has been mostly phased out of U.S. production due to environmental persistence, detectable human and wildlife serum concentrations, and reports of systemic toxicity. In rodent models, PFOA exposure suppresses T cell-dependent antibody responses (TDAR) and vaccine responses in exposed humans. To determine replacement compound effects on TDAR and related parameters, male and female C57BL/6 mice were gavaged with 0, 1, 10, or 100 mg/kg/day for 28 days. Mice immunized with antigen on day 24 were evaluated for TDAR and splenic lymphocyte subpopulations five days later. Serum and urine were collected for test compound concentrations and liver peroxisome proliferation was measured. Relative liver weight at 10 and 100 mg/kg and peroxisome proliferation at 100 mg/kg were increased in both sexes. TDAR was suppressed in females at 100 mg/kg. T lymphocyte numbers were increased in males at 100 mg/kg; B lymphocyte numbers were unchanged in both sexes. Females had less serum accumulation and higher clearance than males, and males had higher urine concentrations than females at all times and doses. While this PFOA-replacement compound appears less potent at suppressing TDAR relative to PFOA, it produces detectable changes in parameters affected by PFOA; further studies are necessary to determine its full immunomodulatory profile and potential synergism with other per- and polyfluoroalkyl substances of environmental concern.

Journal article

Dagnino S, Strynar MJ, McMahen RL, Lau CS, Ball C, Garantziotis S, Webster TF, McClean MD, Lindstrom ABet al., 2016, Identification of Biomarkers of Exposure to FTOHs and PAPs in Humans Using a Targeted and Nontargeted Analysis Approach, ENVIRONMENTAL SCIENCE & TECHNOLOGY, Vol: 50, Pages: 10216-10225, ISSN: 0013-936X

Journal article

Anumol T, Dagnino S, Vandervort DR, Snyder SAet al., 2016, Transformation of Polyfluorinated compounds in natural waters by advanced oxidation processes, CHEMOSPHERE, Vol: 144, Pages: 1780-1787, ISSN: 0045-6535

Journal article

Strynar M, Dagnino S, McMahen R, Liang S, Lindstrom A, Andersen E, McMillan L, Thurman M, Ferrer I, Ball Cet al., 2015, Identification of Novel Perfluoroalkyl Ether Carboxylic Acids (PFECAs) and Sulfonic Acids (PFESAs) in Natural Waters Using Accurate Mass Time-of-Flight Mass Spectrometry (TOFMS), ENVIRONMENTAL SCIENCE & TECHNOLOGY, Vol: 49, Pages: 11622-11630, ISSN: 0013-936X

Journal article

Tucker DK, Macon MB, Strynar MJ, Dagnino S, Andersen E, Fenton SEet al., 2015, The mammary gland is a sensitive pubertal target in CD-1 and C57Bl/6 mice following perinatal perfluorooctanoic acid (PFOA) exposure, REPRODUCTIVE TOXICOLOGY, Vol: 54, Pages: 26-36, ISSN: 0890-6238

Journal article

McMahen RL, Strynar MJ, Dagnino S, Herr DW, Moser VC, Garantziotis S, Andersen EM, Freeborn DL, McMillan L, Lindstrom ABet al., 2015, Identification of fipronil metabolites by time-of-flight mass spectrometry for application in a human exposure study, ENVIRONMENT INTERNATIONAL, Vol: 78, Pages: 16-23, ISSN: 0160-4120

Journal article

Dagnino S, 2015, Analysis of PFASs in Biological Tissues and Fluids, TOXICOLOGICAL EFFECTS OF PERFLUOROALKYL AND POLYFLUOROALKYL SUBSTANCES, Editors: DeWitt, Publisher: SPRINGER-VERLAG LONDON LTD, Pages: 23-49, ISBN: 978-3-319-15517-3

Book chapter

Rauch-Williams T, Bieber S, Dagnino S, Dickenson E, Drewes JE, Letzel T, Snyder Set al., 2014, Review of national &amp; International management approaches for compounds of emerging concerns, Pages: 1082-1094

In the U.S., federal, regional, local, and state regulatory agencies struggle to develop CEC management plans that provide assurance to the public, while balancing often incomplete risk profiles and increasing lists of detected compounds. Several federal programs exist for the management and control of CECs, but the extent and scope or these individual programs and their relative interaction are not widely understood. Outside of the U.S., several countries have proposed or implemented alternative management strategies to the U.S. for CECs in water. Most noticeable are initiatives in the European Union, Switzerland, Germany, Asia, and Australia. This paper summarizes programs for CECs in the U.S., the European Union, and Switzerland. Regulatory and non-regulatory CEC management strategies are discussed and placed in the relevant regulatory, social-political, and topographical context specific to each country.

Conference paper

Snyder SA, Jia A, Dong B, Wu S, Anumol T, Merel S, Dagnino Set al., 2014, Monitoring for pharmaceuticals and EDCs using advanced analytical and bioanalytical tools, 248th National Meeting of the American-Chemical-Society (ACS), Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727

Conference paper

Anumol T, Dagnino S, VanDervort D, Snyder SAet al., 2014, Transformation of polyfluorinated compounds in natural waters by advanced oxidation processes, 248th National Meeting of the American-Chemical-Society (ACS), Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727

Conference paper

Dagnino S, Bellet V, Grimaldi M, Riu A, Ait-Aissa S, Cavailles V, Fenet H, Balaguer Pet al., 2014, Affinity Purification Using Recombinant PXR as a Tool to Characterize Environmental Ligands, ENVIRONMENTAL TOXICOLOGY, Vol: 29, Pages: 207-215, ISSN: 1520-4081

Journal article

Patureau D, Delgenes N, Muller M, Dagnino S, Lhoutellier C, Delgenes J-P, Balaguer P, Hernandez-Raquet Get al., 2012, Chemical and toxicological assessment of a full-scale biosolid compost, ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, Vol: 31, Pages: 2748-2756, ISSN: 0730-7268

Journal article

Bellet V, Hernandez-Raquet G, Dagnino S, Seree L, Pardon P, Bancon-Montiny C, Fenet H, Creusot N, Ait-Aissa S, Cavailles V, Budzinski H, Antignac J-P, Balaguer Pet al., 2012, Occurrence of androgens in sewage treatment plants influents is associated with antagonist activities on other steroid receptors, WATER RESEARCH, Vol: 46, Pages: 1912-1922, ISSN: 0043-1354

Journal article

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