Imperial College London

DrStefanoSandrone

Faculty of MedicineDepartment of Brain Sciences

Teaching Fellow
 
 
 
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Contact

 

stefano.sandrone Website

 
 
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Location

 

C3NLBurlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
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29 results found

Hampshire A, Sandrone S, Hellyer P, 2019, A large-scale, cross-sectional investigation into the efficacy of brain training, Frontiers in Neuroscience, Vol: 13, Pages: 1-13, ISSN: 1662-4548

Brain training is a large and expanding industry, and yet there is a recurrent and ongoing debate concerning its scientific basis or evidence for efficacy. Much of evidence for the efficacy of brain training within this debate is from small-scale studies that do not assess the type of “brain training,” the specificity of transfer effects, or the length of training required to achieve a generalized effect. To explore these factors, we analyze cross-sectional data from two large Internet-cohort studies (total N = 60,222) to determine whether cognition differs at the population level for individuals who report that they brain train on different devices, and across different timeframes, with programs in common use circa 2010–2013. Examining scores for an assessment of working-memory, reasoning and verbal abilities shows no cognitive advantages for individuals who brain train. This contrasts unfavorably with significant advantages for individuals who regularly undertake other cognitive pursuits such as computer, board and card games. However, finer grained analyses reveal a more complex relationship between brain training and cognitive performance. Specifically, individuals who have just begun to brain train start from a low cognitive baseline compared to individuals who have never engaged in brain training, whereas those who have trained for a year or more have higher working-memory and verbal scores compared to those who have just started, thus suggesting an efficacy for brain training over an extended period of time. The advantages in global function, working memory, and verbal memory after several months of training are plausible and of clinically relevant scale. However, this relationship is not evident for reasoning performance or self-report measures of everyday function (e.g., employment status and problems with attention). These results accord with the view that although brain training programs can produce benefits, these might extend to tasks

Journal article

Sandrone S, Berthaud JV, Carlson C, Cios J, Dixit N, Farheen A, Kraker J, Owens JWM, Patino G, Sarva H, Weber D, Schneider LDet al., 2019, Education Research: Flipped classroom in neurology: Principles, practices, and perspectives., Neurology, Vol: 93, Pages: e106-e111

How to most effectively deliver a large amount of information in an engaging environment that encourages critical thinking is a question that has long plagued educators. With ever-increasing demands on both resident and faculty time, from shrinking duty hours to increased patient complexity, combined with the exponential growth of medical knowledge and unequal access to the spectrum of neurologic subspecialties around the country, this question has become especially pertinent to neurology residency training. A team of educators from the American Academy of Neurology's A.B. Baker Section on Neurological Education sought to review the current evidence regarding the implementation of the flipped classroom format. This educational model has only recently been applied to health care education along the training continuum, and a small collection of articles has, so far, used disparate methods of curricular implementation and assessment. While the feedback from learners is generally positive, a number of obstacles to implementation exist, most notably learner time commitments. These are presented with discussion of potential solutions along with suggestions for future studies.

Journal article

Hampshire A, Daws RE, Neves ID, Soreq E, Sandrone S, Violante IRet al., 2019, Probing cortical and sub-cortical contributions to instruction-based learning: Regional specialisation and global network dynamics, NeuroImage, Vol: 192, Pages: 88-100, ISSN: 1053-8119

Diverse cortical networks and striatal brain regions are implicated in instruction-based learning (IBL); however, their distinct contributions remain unclear. We use a modified fMRI paradigm to test two hypotheses regarding the brain mechanisms that underlie IBL. One hypothesis proposes that anterior caudate and frontoparietal regions transiently co-activate when new rules are being bound in working memory. The other proposes that they mediate the application of the rules at different stages of the consolidation process. In accordance with the former hypothesis, we report strong activation peaks within and increased connectivity between anterior caudate and frontoparietal regions when rule-instruction slides are presented. However, similar effects occur throughout a broader set of cortical and sub-cortical regions, indicating a metabolically costly reconfiguration of the global brain state. The distinct functional roles of cingulo-opercular, frontoparietal and default-mode networks are apparent from their activation throughout, early and late in the practice phase respectively. Furthermore, there is tentative evidence of a peak in anterior caudate activity mid-way through the practice stage. These results demonstrate how performance of the same simple task involves a steadily shifting balance of brain systems as learning progresses. They also highlight the importance of distinguishing between regional specialisation and global dynamics when studying the network mechanisms that underlie cognition and learning.

Journal article

Sandrone S, Moreno-Zambrano D, Kipnis J, van Gijn Jet al., 2019, A (delayed) history of the brain lymphatic system., Nat Med, Vol: 25, Pages: 538-540

Journal article

Sandrone S, Berthaud JV, Chuquilin M, Cios J, Ghosh P, Gottlieb-Smith RJ, Kushlaf H, Mantri S, Masangkay N, Menkes DL, Nevel KS, Sarva H, Schneider LDet al., 2019, Neurologic and neuroscience education Mitigating neurophobia to mentor health care providers, NEUROLOGY, Vol: 92, Pages: 174-179, ISSN: 0028-3878

Journal article

Sandrone S, van Gijn J, 2018, Macdonald Critchley (1900-1997), JOURNAL OF NEUROLOGY, Vol: 265, Pages: 1244-1245, ISSN: 0340-5354

Journal article

Sandrone S, Cambiaghi M, 2018, Ugo Cerletti (1877-1963), JOURNAL OF NEUROLOGY, Vol: 265, Pages: 731-732, ISSN: 0340-5354

Journal article

Zanin E, Moro A, Sandrone S, 2018, Eric Heinz Lenneberg (1921-1975), JOURNAL OF NEUROLOGY, Vol: 265, Pages: 449-450, ISSN: 0340-5354

Journal article

Bacigaluppi M, Russo GL, Peruzzotti-Jametti L, Rossi S, Sandrone S, Butti E, De Ceglia R, Bergamaschi A, Motta C, Gallizioli M, Studer V, Colombo E, Farina C, Comi G, Politi LS, Muzio L, Villani C, Invernizzi RW, Hermann DM, Centonze D, Martino Get al., 2016, Neural Stem Cell Transplantation Induces Stroke Recovery by Upregulating Glutamate Transporter GLT-1 in Astrocytes, JOURNAL OF NEUROSCIENCE, Vol: 36, Pages: 10529-10544, ISSN: 0270-6474

Journal article

Catani M, Dell'Acqua F, Budisavljevic S, Howells H, Thiebaut de Schotten M, Froudist-Walsh S, D'Anna L, Thompson A, Sandrone S, Bullmore ET, Suckling J, Baron-Cohen S, Lombardo MV, Wheelwright SJ, Chakrabarti B, Lai M-C, Ruigrok ANV, Leemans A, Ecker C, Craig MC, Murphy DGMet al., 2016, Frontal networks in adults with autism spectrum disorder, BRAIN, Vol: 139, Pages: 616-630, ISSN: 0006-8950

Journal article

Wiesel T, Sandrone S, 2014, Q&A: Torsten Wiesel. Progress in sight., Nature, Vol: 514, Pages: S11-S12

Journal article

Sandrone S, 2014, Decoupling motor plans from perceptual decisions to investigate whether and when decisions are embodied, JOURNAL OF NEUROPHYSIOLOGY, Vol: 112, Pages: 1603-1605, ISSN: 0022-3077

Journal article

Cambiaghi M, Sandrone S, 2014, Robert Bartholow (1831-1904), JOURNAL OF NEUROLOGY, Vol: 261, Pages: 1649-1650, ISSN: 0340-5354

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Sandrone S, 2014, Giuseppe Moruzzi (1910-1986), JOURNAL OF NEUROLOGY, Vol: 261, Pages: 1447-1448, ISSN: 0340-5354

Journal article

Sandrone S, Riva M, 2014, Bartolomeo Panizza (1785-1867), JOURNAL OF NEUROLOGY, Vol: 261, Pages: 1249-1250, ISSN: 0340-5354

Journal article

Sandrone S, Zanin E, 2014, David Ferrier (1843-1928), JOURNAL OF NEUROLOGY, Vol: 261, Pages: 1247-1248, ISSN: 0340-5354

Journal article

Sandrone S, 2014, Sir Francis Walshe (1885-1973), JOURNAL OF NEUROLOGY, Vol: 261, Pages: 845-846, ISSN: 0340-5354

Journal article

Sandrone S, Bacigaluppi M, Galloni MR, Cappa SF, Moro A, Catani M, Filippi M, Monti MM, Perani D, Martino Get al., 2014, Weighing brain activity with the balance: Angelo Mosso's original manuscripts come to light, BRAIN, Vol: 137, Pages: 621-633, ISSN: 0006-8950

Journal article

Sandrone S, Catani M, 2013, Journal Club: Default-mode network connectivity in cognitively unimpaired patients with Parkinson disease, NEUROLOGY, Vol: 81, Pages: E172-E175, ISSN: 0028-3878

Journal article

Sandrone S, 2013, Norman Geschwind (1926-1984), JOURNAL OF NEUROLOGY, Vol: 260, Pages: 3197-3198, ISSN: 0340-5354

Journal article

Peruzzotti-Jametti L, Cambiaghi M, Bacigaluppi M, Gallizioli M, Gaude E, Mari S, Sandrone S, Cursi M, Teneud L, Comi G, Musco G, Martino G, Leocani Let al., 2013, Safety and Efficacy of Transcranial Direct Current Stimulation in Acute Experimental Ischemic Stroke, STROKE, Vol: 44, Pages: 3166-3174, ISSN: 0039-2499

Journal article

Sandrone S, 2013, A DMN-based functional taxonomy of the resting human brain: Is essential really invisible to the eye?, BRAIN RESEARCH BULLETIN, Vol: 99, Pages: A1-A3, ISSN: 0361-9230

Journal article

Sandrone S, 2013, Self through the mirror (neurons) and default mode network: what neuroscientists found and what can still be found there, FRONTIERS IN HUMAN NEUROSCIENCE, Vol: 7, ISSN: 1662-5161

Journal article

Sandrone S, Safron A, 2013, Pain and (e)motion in postural responses, FRONTIERS IN HUMAN NEUROSCIENCE, Vol: 7, ISSN: 1662-5161

Journal article

Sandrone S, 2013, Rita Levi-Montalcini (1909-2012), JOURNAL OF NEUROLOGY, Vol: 260, Pages: 940-941, ISSN: 0340-5354

Journal article

Peruzzotti-Jametti L, Bacigaluppi M, Sandrone S, Cambiaghi Met al., 2013, Emerging Subspecialties in Neurology: Transcranial stimulation, NEUROLOGY, Vol: 80, Pages: E33-E35, ISSN: 0028-3878

Journal article

Sandrone S, Bacigaluppi M, Galloni MR, Martino Get al., 2012, Angelo Mosso (1846-1910), JOURNAL OF NEUROLOGY, Vol: 259, Pages: 2513-2514, ISSN: 0340-5354

Journal article

Sandrone S, 2012, The brain as a crystal ball: the predictive potential of Default Mode Network, FRONTIERS IN HUMAN NEUROSCIENCE, Vol: 6, ISSN: 1662-5161

Journal article

Sandrone S, Bacigaluppi M, 2012, Learning from Default Mode Network: The Predictive Value of Resting State in Traumatic Brain Injury, JOURNAL OF NEUROSCIENCE, Vol: 32, Pages: 1915-1917, ISSN: 0270-6474

Journal article

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