Imperial College London


Faculty of MedicineDepartment of Surgery & Cancer

Professor of Critical Care



+44 (0)20 3313 4521stephen.brett Website




Hammersmith House 570Hammersmith HospitalHammersmith Campus





Professor Stephen Brett is head for research for the Directorate of Anaesthetics and Critical Care within Imperial College Healthcare NHS Trust, leading the Centre for Perioperative Medicine and Critical Care Research and Professor of Critical Care at Imperial College.  The Centre is developing a unique agenda of patient focused projects along the entirety of patient journey, be it in surgery or critical illness, and of course resuscitation; these projects range from epidemiology and public health, through clinical trials to evaluation of the impact of surgery on chronic diseases and of course technology evaluation. The Centre supports many Comprehensive Research Network portfolio studies and is supported through this and the Biomedical Research Centre Scheme.

Professor Brett's personal research interests are in understanding and optimizing long term outcomes after critical illness. He is chief investigator for a number of clinical studies both locally and nationally. He recently lead the NICE guidline development group which published the guideline "Rehabilitation after Critical Illness" (

Prof. Brett is President of the Intensive Care Society  and is an Editor of the journal Critical Care. In addition he serves on a number of Department of Health advisory groups, and provides consultancy to industry in the fields of clinical trial design and supervision, and marketing. 



Patel PB, Brett S, O'Callaghan D, et al., 2020, A randomized clinical trial of methylnaltrexone for the treatment of opioid induced constipation & gastrointestinal stasis in intensive care patients; results from the MOTION trial, Intensive Care Medicine, ISSN:0342-4642

Grailey K, Murray E, Billings J, et al., 2020, How do critical care staff respond to organisational challenge? A qualitative exploration into personality types and cognitive processing in critical care, Plos One, Vol:15, ISSN:1932-6203

Bauchmuller K, Manson J, Tattersall R, et al., Haemophagocytic lymphohistiocytosis in adult critical care, Journal of the Intensive Care Society, ISSN:1751-1437

Palmer E, Post B, Klapaukh R, et al., 2019, The association between supra-physiologic arterial oxygen levels and mortality in critically ill patients: a multi-centre observational cohort study, American Journal of Respiratory and Critical Care Medicine, Vol:200, ISSN:1073-449X, Pages:1373-1380

Wandrag L, Brett SJ, Frost G, et al., 2019, Leucine-enriched essential amino acid supplementation in mechanically ventilated trauma patients – a feasibility study, Trials, Vol:20, ISSN:1745-6215

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