Imperial College London

ProfessorStephenBrett

Faculty of MedicineDepartment of Surgery & Cancer

Professor of Critical Care
 
 
 
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Contact

 

+44 (0)20 3313 4521stephen.brett Website

 
 
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Location

 

Hammersmith House 570Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

221 results found

Wong JLC, Brett SJ, 2013, The assessment and risk stratification of psychological morbidity in critical care survivors, CRITICAL CARE, Vol: 17, ISSN: 1466-609X

Journal article

Griffiths J, Brett SJ, 2013, Follow-up, Core Topics in Cardiothoracic Critical Care, Pages: 442-449, ISBN: 9780521872836

© Cambridge University Press 2008. Introduction Although mortality and survival are easy to understand and measure, survival alone is an incomplete endpoint for the recovery from critical illness or major surgery. Therefore, patient outcome fromcritical care treatment is not only described in terms of longer term survival (‘mortality’ outcomes), but also incorporates quality of life and neuropsychological and functional status (ʼnonmortality’ outcomes). Assessment of these broader long-term outcome measures requires organized long-term follow-up that often extends to 12 months after hospital discharge. Critical care follow-up clinics have highlighted the variety of physical, psychological and psychosocial complaints experienced by patients as they recover from their critical care experience and treatment. Patients requiring more than a 2- to 3-day critical care stay after cardiothoracic surgery tend to experience similar long-term outcomes as noncardiac patients. This chapter focuses on some of these long-term, patient-centred outcomes.

Book chapter

Patel A, Waheed U, Brett SJ, Rahemtulla A, Apperley J, Patel Pet al., 2013, Rapid initial response of myeloma hyperammonemic encephalopathy to L-ornithine-L-aspartate (LOLA) and dexamethasone therapy, Leukemia & Lymphoma

Journal article

McKay A, Walker ST, Brett SJ, Vincent C, Sevdalis Net al., 2012, Team performance in resuscitation teams: Comparison and critique of two recently developed scoring tools, RESUSCITATION, Vol: 83, Pages: 1478-1483, ISSN: 0300-9572

Journal article

Walker ST, Brett SJ, McKay A, Aggarwal R, Vincent Cet al., 2012, The "Resus:Station": The use of clinical simulations in a randomised crossover study to evaluate a novel resuscitation trolley, RESUSCITATION, Vol: 83, Pages: 1374-1380, ISSN: 0300-9572

Journal article

Hill NE, Murphy KG, Brett S, Wilson DR, Frost G, Dhillo W, Bloom SR, Singer Met al., 2012, CAN THE GASTRIC HORMONE GHRELIN ATTENUATE CATABOLISM AND ENHANCE RECOVERY AND REHABILITATION IN A RODENT MODEL OF ZYMOSAN PERITONITIS?, INTENSIVE CARE MEDICINE, Vol: 38, Pages: S122-S122, ISSN: 0342-4642

Journal article

Dolan GP, Myles PR, Brett SJ, Enstone JE, Read RC, Openshaw PJM, Semple MG, Lim WS, Taylor BL, McMenamin J, Nicholson KG, Bannister B, Nguyen-Van-Tam JSet al., 2012, The Comparative Clinical Course of Pregnant and Non-Pregnant Women Hospitalised with Influenza A(H1N1)pdm09 Infection, PLOS ONE, Vol: 7, ISSN: 1932-6203

Journal article

Myles PR, Semple MG, Lim WS, Openshaw PJM, Gadd EM, Read RC, Taylor BL, Brett SJ, McMenamin J, Enstone JE, Armstrong C, Bannister B, Nicholson KG, Nguyen-Van-Tam JSet al., 2012, Predictors of clinical outcome in a national hospitalised cohort across both waves of the influenza A/H1N1 pandemic 2009-2010 in the UK, THORAX, Vol: 67, Pages: 709-717, ISSN: 0040-6376

Journal article

Everitt AR, Clare S, Pertel T, John SP, Wash RS, Smith SE, Chin CR, Feeley EM, Sims JS, Adams DJ, Wise HM, Kane L, Goulding D, Digard P, Anttila V, Baillie JK, Walsh TS, Hume DA, Palotie A, Xue Y, Colonna V, Tyler-Smith C, Dunning J, Gordon SB, GenISIS Investigators, MOSAIC Investigators, Smyth RL, Openshaw PJ, Dougan G, Brass AL, Kellam Pet al., 2012, IFITM3 restricts the morbidity and mortality associated with influenza., Nature, Vol: 484, Pages: 519-523

The 2009 H1N1 influenza pandemic showed the speed with which a novel respiratory virus can spread and the ability of a generally mild infection to induce severe morbidity and mortality in a subset of the population. Recent in vitro studies show that the interferon-inducible transmembrane (IFITM) protein family members potently restrict the replication of multiple pathogenic viruses1, 2, 3, 4, 5, 6, 7. Both the magnitude and breadth of the IFITM proteins’ in vitro effects suggest that they are critical for intrinsic resistance to such viruses, including influenza viruses. Using a knockout mouse model8, we now test this hypothesis directly and find that IFITM3 is essential for defending the host against influenza A virus in vivo. Mice lacking Ifitm3 display fulminant viral pneumonia when challenged with a normally low-pathogenicity influenza virus, mirroring the destruction inflicted by the highly pathogenic 1918 ‘Spanish’ influenza9, 10. Similar increased viral replication is seen in vitro, with protection rescued by the re-introduction of Ifitm3. To test the role of IFITM3 in human influenza virus infection, we assessed the IFITM3 alleles of individuals hospitalized with seasonal or pandemic influenza H1N1/09 viruses. We find that a statistically significant number of hospitalized subjects show enrichment for a minor IFITM3 allele (SNP rs12252-C) that alters a splice acceptor site, and functional assays show the minor CC genotype IFITM3 has reduced influenza virus restriction in vitro. Together these data reveal that the action of a single intrinsic immune effector, IFITM3, profoundly alters the course of influenza virus infection in mouse and humans.

Journal article

Myles PR, Nguyen-Van-Tam JS, Lim WS, Nicholson KG, Brett SJ, Enstone JE, McMenamin J, Openshaw PJM, Read RC, Taylor BL, Bannister B, Semple MGet al., 2012, Comparison of CATs, CURB-65 and PMEWS as Triage Tools in Pandemic Influenza Admissions to UK Hospitals: Case Control Analysis Using Retrospective Data, PLOS ONE, Vol: 7, ISSN: 1932-6203

Journal article

Patel A, Punjabi PP, Jarvis S, McKinnon T, Manning R, Brett S, Laffan MA, Waheed Uet al., 2012, Impaired primary haemostasis in severe sepsis despite elevated von Willebrand factor, 52nd Annual Scientific Meeting of the British-Society-for-Haematology, Publisher: WILEY-BLACKWELL, Pages: 35-36, ISSN: 0007-1048

Conference paper

Terblanche M, Kruger P, di Gangi S, Gearay S, Gilfeather L, Ferguson ND, Pearse R, Beale R, Rhodes A, Brett SJ, McAuley DFet al., 2012, Risk factors for acute organ failure in intensive care unit patients who receive respiratory support in the absence of non-respiratory organ failure: an international prospective cohort study, CRITICAL CARE, Vol: 16, ISSN: 1466-609X

Journal article

Connolly B, Denehy L, Brett S, Elliott D, Hart Net al., 2012, Exercise rehabilitation following hospital discharge in survivors of critical illness: an integrative review, CRITICAL CARE, Vol: 16, ISSN: 1466-609X

Journal article

Arulkumaran N, West S, Chan K, Templeton M, Taube D, Brett SJet al., 2012, Long-term renal function and survival of renal transplant recipients admitted to the intensive care unit, CLINICAL TRANSPLANTATION, Vol: 26, Pages: E24-E31, ISSN: 0902-0063

Journal article

Brett S, 2011, Critical care outcomes: current and future issues, CURRENT OPINION IN CRITICAL CARE, Vol: 17, Pages: 493-494, ISSN: 1070-5295

Journal article

Walker S, Brett S, McKay A, Lambden S, Vincent C, Sevdalis Net al., 2011, Observational Skill-based Clinical Assessment tool for Resuscitation (OSCAR): Development and validation, RESUSCITATION, Vol: 82, Pages: 835-844, ISSN: 0300-9572

Journal article

Garland P, de Lavallade H, Sekine T, Hoschler K, Sriskandan S, Patel P, Brett S, Stringaris K, Loucaides E, Howe K, Marin D, Kanfer E, Cooper N, Macdonald D, Rahemtulla A, Atkins M, Danga A, Milojkovic D, Gabriel I, Khoder A, Alsuliman A, Apperley J, Rezvani Ket al., 2011, Humoral and Cellular Immunity to Primary H1N1 Infection in Patients with Hematologic Malignancies following Stem Cell Transplantation, BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, Vol: 17, Pages: 632-639, ISSN: 1083-8791

Journal article

Brett SJ, Myles P, Lim WS, Enstone JE, Bannister B, Semple MG, Read RC, Taylor BL, McMenamin J, Nicholson KG, Nguyen-Van-Tam JS, Openshaw PJMet al., 2011, Pre-Admission Statin Use and In-Hospital Severity of 2009 Pandemic Influenza A(H1N1) Disease, PLOS ONE, Vol: 6, ISSN: 1932-6203

Journal article

Bewick T, Myles P, Greenwood S, Nguyen-Van-Tam JS, Brett SJ, Semple MG, Openshaw PJ, Bannister B, Read RC, Taylor BL, McMenamin J, Enstone JE, Nicholson KG, Lim WSet al., 2011, Clinical and laboratory features distinguishing pandemic H1N1 influenza-related pneumonia from interpandemic community-acquired pneumonia in adults, THORAX, Vol: 66, Pages: 247-252, ISSN: 0040-6376

Journal article

Elliott VJ, Rodgers DL, Brett SJ, 2011, Systematic review of quality of life and other patient-centred outcomes after cardiac arrest survival, RESUSCITATION, Vol: 82, Pages: 247-256, ISSN: 0300-9572

Journal article

Terblanche MJ, Pinto R, Whiteley C, Brett S, Beale R, Adhikari NKJet al., 2011, Statins do not prevent acute organ failure in ventilated ICU patients: single-centre retrospective cohort study, CRITICAL CARE, Vol: 15, ISSN: 1466-609X

Journal article

Camporota L, Brett S, 2011, Care bundles: implementing evidence or common sense?, CRITICAL CARE, Vol: 15, ISSN: 1466-609X

Journal article

Pinto A, Burnett S, Benn J, Brett S, Parand A, Iskander S, Vincent Cet al., 2011, Improving reliability of clinical care practices for ventilated patients in the context of a patient safety improvement initiative, Journal of evaluation in clinical practice, Vol: 17, Pages: 180-187, ISSN: 1365-2753

Journal article

Walker S, Brett S, 2010, Oiling the wheels of intensive care to reduce "machine friction": The best way to improve outcomes?, CRITICAL CARE MEDICINE, Vol: 38, Pages: S642-S648, ISSN: 0090-3493

Journal article

Price LC, Wort SJ, Finney SJ, Marino PS, Brett SJet al., 2010, Pulmonary vascular and right ventricular dysfunction in adult critical care: current and emerging options for management: a systematic literature review, Critical Care, Vol: 14, ISSN: 1364-8535

Introduction: Pulmonary vascular dysfunction, pulmonary hypertension (PH), and resulting right ventricular (RV)failure occur in many critical illnesses and may be associated with a worse prognosis. PH and RV failure may bedifficult to manage: principles include maintenance of appropriate RV preload, augmentation of RV function, andreduction of RV afterload by lowering pulmonary vascular resistance (PVR). We therefore provide a detailed updateon the management of PH and RV failure in adult critical care.Methods: A systematic review was performed, based on a search of the literature from 1980 to 2010, by usingprespecified search terms. Relevant studies were subjected to analysis based on the GRADE method.Results: Clinical studies of intensive care management of pulmonary vascular dysfunction were identified,describing volume therapy, vasopressors, sympathetic inotropes, inodilators, levosimendan, pulmonary vasodilators,and mechanical devices. The following GRADE recommendations (evidence level) are made in patients withpulmonary vascular dysfunction: 1) A weak recommendation (very-low-quality evidence) is made that closemonitoring of the RV is advised as volume loading may worsen RV performance; 2) A weak recommendation (lowqualityevidence) is made that low-dose norepinephrine is an effective pressor in these patients; and that 3) lowdosevasopressin may be useful to manage patients with resistant vasodilatory shock. 4) A weak recommendation(low-moderate quality evidence) is made that low-dose dobutamine improves RV function in pulmonary vasculardysfunction. 5) A strong recommendation (moderate-quality evidence) is made that phosphodiesterase type IIIinhibitors reduce PVR and improve RV function, although hypotension is frequent. 6) A weak recommendation(low-quality evidence) is made that levosimendan may be useful for short-term improvements in RV performance.7) A strong recommendation (moderate-quality evidence) is made that pulmonary vasodilators reduce PVR andimpro

Journal article

Walunj A, Thomson G, Gent N, Dunning J, Brett SJet al., 2010, Global clinical networking and pandemic influenza, Journal of the Intensive Care Society, Vol: 11, Pages: 165-170, ISSN: 1751-1437

From June 2009 to February 2010, the Health Protection Agency hosted a clinical network including regularteleconferences, with the aim of sharing clinical experiences of the international participants about pandemic influenza.The minutes of the teleconferences over a two month period were analysed to identify clinical themes. A systematicliterature search was then undertaken to identify peer-reviewed publications that either supported or refuted thesethemes. Observations relating to patient demographics, clinical features and clinical management were supported bypublished literature. Younger adults and children were more likely to be infected, but young adults were more likely torequire intensive care. Obesity, pregnancy and asthma were confirmed as risk factors for severe influenza illness. Extrapulmonaryorgan dysfunction was common, often requiring specific interventions. The benefit of certain ventilatory andnon-ventilatory interventions remains unclear, although they were frequently used. This global clinical networking modelfacilitated the real-time exchange of valuable clinical information and provided the basis for clinical practice notes.

Journal article

Nguyen-Van-Tam JS, Openshaw PJM, Hashim A, Gadd EM, Lim WS, Semple MG, Read RC, Taylor BL, Brett SJ, McMenamin J, Enstone JE, Armstrong C, Nicholson KGet al., 2010, Risk factors for hospitalisation and poor outcome with pandemic A/H1N1 influenza: United Kingdom first wave (May-September 2009), THORAX, Vol: 65, Pages: 645-651, ISSN: 0040-6376

Journal article

Patel A, Waheed U, Brett S, Rahemtulla A, Apperley JF, Patel Pet al., 2010, Rapid response of myeloma hyperammonaemic encephalopathy to L-ornithine-L-aspartate therapy, 50th Annual Scientific Meeting of the British-Society-for-Haematology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 58-58, ISSN: 0007-1048

Conference paper

Patel A, Waheed U, Brett S, Rahemtulla A, Apperley JF, Patel Pet al., 2010, Rapid response of myeloma hyperammonaemic encephalopathy to L-ornithine-L-aspartate therapy, British Journal of Haematology, Vol: 149

Journal article

Spearpoint KG, Gruber PC, Brett SJ, 2009, Impact of the Immediate Life Support course on the incidence and outcome of in-hospital cardiac arrest calls: An observational study over 6 years, RESUSCITATION, Vol: 80, Pages: 638-643, ISSN: 0300-9572

Journal article

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