Imperial College London

ProfessorStephenBrett

Faculty of MedicineDepartment of Surgery & Cancer

Professor of Critical Care
 
 
 
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Contact

 

+44 (0)20 3313 4521stephen.brett Website

 
 
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Location

 

Hammersmith House 570Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

221 results found

Whittington AM, Whitlow G, Hewson D, Thomas C, Brett SJet al., 2009, Bacterial contamination of stethoscopes on the intensive care unit, ANAESTHESIA, Vol: 64, Pages: 620-624, ISSN: 0003-2409

Journal article

Tan T, Brett SJ, Stokes T, 2009, Guidelines: Rehabilitation after critical illness: summary of NICE guidance, BMJ (Online), Vol: 338

Journal article

Tan T, Brett SJ, Stokes T, 2009, Guidelines Rehabilitation after critical illness: summary of NICE guidance, BRITISH MEDICAL JOURNAL, Vol: 338, ISSN: 0959-535X

Journal article

Chapman RJ, Templeton M, Ashworth S, Broomhead R, McLean A, Brett SJet al., 2009, Long-term survival of chronic dialysis patients following survival from an episode of multiple-organ failure, CRITICAL CARE, Vol: 13, ISSN: 1466-609X

Journal article

Sevdalis N, Brett SJ, 2009, Improving care by understanding the way we work: human factors and behavioural science in the context of intensive care, CRITICAL CARE, Vol: 13, ISSN: 1466-609X

Journal article

Eisen DP, Dean MM, Boermeester MA, Fidler KJ, Gordon AC, Kronborg G, Kun JFJ, Lau YL, Payeras A, Valdimarsson H, Brett SJ, Ip WKE, Mila J, Peters MJ, Saevarsdottir S, van Till JWO, Hinds CJ, McBryde ESet al., 2008, Low serum mannose-binding lectin level increases the risk of death due to pneumococcal infection, CLINICAL INFECTIOUS DISEASES, Vol: 47, Pages: 510-516, ISSN: 1058-4838

Journal article

Nematy M, Brynes AE, Hornick PI, Patterson M, Ghatei MA, Bloom SR, Brett SJ, Frost GSet al., 2007, Postprandial ghrelin suppression is exaggerated following major surgery; implications for nutritional recovery, Nutrition & Metabolism, Vol: 4, ISSN: 1743-7075

Journal article

Chapman RJ, Brett SJ, 2007, Cognitive dysfunction in intensive care survivors, BRITISH JOURNAL OF HOSPITAL MEDICINE, Vol: 68, Pages: 467-469, ISSN: 1750-8460

Journal article

Price LC, Brett SJ, Howard LS, 2007, The use of vasopressors in pulmonary hypertension on the intensive care unit., Br J Hosp Med (Lond), Vol: 68, ISSN: 1750-8460

Journal article

Sukantarat KT, Williamson RCN, Brett SJ, 2007, Psychological assessment of ICU survivors: a comparison between the Hospital Anxiety and Depression scale and the Depression, Anxiety and Stress scale, ANAESTHESIA, Vol: 62, Pages: 239-243, ISSN: 0003-2409

Journal article

Garner J, Brett SJ, 2007, Mechanisms of injury by explosive devices., Anesthesiol Clin, Vol: 25, Pages: 147-x, ISSN: 1932-2275

Explosive devices cause injury by four mechanisms, of which primary blast injury is the least familiar to most non-military clinicians. The pathophysiology of the various mechanisms of injury is described, and the implications for translating a knowledge of mechanism of injury to clinical management is discussed.

Journal article

Sukantarat K, Greer S, Brett S, Williamson Ret al., 2007, Physical and psychological sequelae of critical illness, BRITISH JOURNAL OF HEALTH PSYCHOLOGY, Vol: 12, Pages: 65-74, ISSN: 1359-107X

Journal article

Allen DJ, Harvey B, Brett SJ, 2007, "FOURCRACK"-An investigation of the creep performance of advanced high alloy steel welds, International Journal of Pressure Vessels and Piping, Vol: 84, Pages: 104-113, ISSN: 0308-0161

Creep failure by "Type IV" cracking in the weld heat-affected zone (HAZ) is likely to be the life-limiting failure mechanism in high-alloy steel components for advanced power plant. A UK collaborative project, "FOURCRACK", has therefore been carried out to investigate and compare the cross-weld creep rupture performance of several casts of the advanced steels E911, P92, and P122, and the established steel P91. The experimental matrix included both stress and temperature variations while minimising the testing required to characterise the comparative performance of different welded materials. The results clarify the interplay between weld metal and HAZ failure mechanisms, the relationships between parent material and cross-weld creep strength, and the relative merits of the alternative steels. Finally, problems which arise in the assessment of cross-weld creep test data are discussed, and recommendations put forward to address the risks of biased assessment when failure can take place in different locations within the weldment. © 2006 Elsevier Ltd. All rights reserved.

Journal article

Arawwawala D, Brett SJ, 2007, Clinical review: Beyond immediate survival from resuscitation long-term outcome considerations after cardiac arrest, CRITICAL CARE, Vol: 11, ISSN: 1466-609X

Journal article

Arawwawala D, Brett S, 2006, Changes to the European Resuscitation Council cardiac arrest management guidelines - A commentary, British Journal of Cardiology, Vol: 13, Pages: 425-429, ISSN: 0969-6113

The European Resuscitation Council guidelines for the management of cardiac arrest have been updated. The following commentary discusses the major changes, the evidence on which they are based and the practical issues of their introduction.

Journal article

Suntharalingam G, Perry MR, Ward S, Brett SJ, Castello-Cortes A, Brunner MD, Panoskaltsis Net al., 2006, Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 355, Pages: 1018-1028, ISSN: 0028-4793

Journal article

Payne EM, Brett SJ, Laffan MA, 2006, Efficacy of recombinant activated factor VII in unselected patients with uncontrolled haemorrhage: a single centre experience, BLOOD COAGULATION & FIBRINOLYSIS, Vol: 17, Pages: 397-402, ISSN: 0957-5235

Journal article

Bradlow W, Brett S, 2006, Management of pulmonary arterial hypertension, Care of the Critically Ill, Vol: 22, Pages: 57-61, ISSN: 0266-0970

Pulmonary arterial hypertension (PAH) is a rare entity with a poor prognosis. With increasing recognition, growing numbers of health care professionals, including those outside designated specialist centres, will be involved in the care of patients with PAH. This review discusses current treatment and the evidence base supporting their use. Attention is also given to future developments and the PAH patient in intensive care.

Journal article

Fong KJ, Lohn JWG, Brett SJ, Healy M, Leonard R, Lackey D, Montgomery HM, Shaw S, Shirley P, Ward P, Whitely C, Withey S, Challoner Eet al., 2006, The 7th of July London suicide bombings - One year on, Care of the Critically Ill, Vol: 22, Pages: 53-54, ISSN: 0266-0970

Journal article

Nematy M, O'Flynn JE, Wandrag L, Brynes AE, Brett SJ, Patterson M, Ghatei MA, Bloom SR, Frost GSet al., 2006, Authors' response [2], Critical Care, Vol: 10, ISSN: 1364-8535

Journal article

Terblanche M, Brett SJ, 2006, Systemic inflammatory response syndrome and complications after surgery, JOURNAL OF CRITICAL CARE, Vol: 21, Pages: 53-55, ISSN: 0883-9441

Journal article

Tillyard A, Kuper M, Brett S, 2006, The difficulties that exist putting ethical theory into practice in critical care, Clinical Intensive Care, Vol: 17, Pages: 1-7, ISSN: 0956-3075

At a recent General Medical Council conference it was suggested by Dame Janet Smith, author of the Shipman inquiry report, that medical students should be assessed on their understanding of ethical principles (GMC Education Conference, May 9, 2005). Indeed, issues of medical ethics have recently made headline news around the world. In England, the right of a patient with progressive cerebellar ataxia to compel doctors to continued feeding for so long as he wishes is under appeal (Dyer, C. The Guardian, London, May 16th, 2005). In America, the recent death following withdrawal of feeding from Terri Schiavo, who was in a persistent vegetative state since 1990, taxed doctors, legislators and politicians up to the White House (Stolberg, SG, The New York Times, April 1, 2005). While such high profile cases arise exceptionally, critical care routinely involves ethical considerations, either implicitly or explicitly. This review describes various ethical principles commonly employed in relation to critical care, and the common problems with their application in the practice of managing the critically ill patient.

Journal article

Grover M, Talwalkar S, Casbard A, Boralessa H, Contreras M, Boralessa H, Brett S, Goldhill DR, Soni Net al., 2006, Silent myocardial ischaemia and haemoglobin concentration: a randomized controlled trial of transfusion strategy in lower limb arthroplasty, VOX SANGUINIS, Vol: 90, Pages: 105-112, ISSN: 0042-9007

Journal article

Nematy M, O'Flynn JE, Wandrag L, Brynes AE, Brett SJ, Patterson M, Ghatei MA, Bloom SR, Frost GSet al., 2006, Changes in appetite related gut hormones in intensive care unit patients: a pilot cohort study, Critical care (London, England), Vol: 10

METHODS: Sixteen ICU patients (60 +/- 4.7 years, body mass index (BMI) 28.1 +/- 1.7 kg/m2 (mean +/- standard error of the mean)) underwent fasting blood sample collections on days 1, 3, 5, 14, 21 and 28 of their stay at Hammersmith and Charing Cross Hospitals. Changes in appetite and biochemical and anthropometric markers of nutritional status were recorded. A comparison was made to a group of 36 healthy volunteers matched for age and BMI (54.3 +/- 2.9 years, p = 0.3; BMI 25.8 +/- 0.8 kg/m2 p = 0.2). RESULTS: Compared to healthy subjects, ICU patients exhibited a significantly lower level of ghrelin (day one 297.8 +/- 76.3 versus 827.2 +/- 78.7 pmol/l, p < 0.001) during their stay in the ICU. This tended to rise to the normal level during the last three weeks of hospital stay. Conversely, ICU patients showed a significantly higher level of PYY (day one 31.5 +/- 9.6 versus 11.3 +/- 1.0 pmol/l, p < 0.05) throughout their stay in the ICU and on the ward, with a downward trend to the normal level during the last three weeks of stay. CONCLUSIONS: Results from our study show high levels of PYY and low levels of ghrelin in ICU patients compared to healthy controls. There appears to be a relationship between the level of these gut hormones and nutritional intake. INTRODUCTION: The nutritional status of patients in the intensive care unit (ICU) appears to decline not only during their stay in the ICU but also after discharge from the ICU. Recent evidence suggests that gut released peptides, such as ghrelin and peptide YY (PYY) regulate the initiation and termination of meals and could play a role in the altered eating behaviour of sick patients. The aim of this study was to assess the patterns of ghrelin and PYY levels during the stay of ICU patients in hospital.

Journal article

Kalbag A, Kotyra Z, Richards M, Spearpoint K, Brett SJet al., 2006, Long-term survival and residual hazard after in-hospital cardiac arrest, RESUSCITATION, Vol: 68, Pages: 79-83, ISSN: 0300-9572

Journal article

Hudson SJ, Brett SJ, 2006, Heterotopic ossification - a long-term consequence of prolonged immobility, CRITICAL CARE, Vol: 10, ISSN: 1466-609X

Journal article

Nematy M, Brynes AE, Hornick PI, Brett SJ, Frost GSet al., 2006, Postprandial ghrelin suppression is exaggerated following major surgery; implications for nutritional recovery., PROCEEDINGS OF THE NUTRITION SOCIETY, Vol: 65, Pages: 63A-63A, ISSN: 0029-6651

Journal article

Gordon AC, Waheed U, Hansen TK, Hitman GA, Garrard CS, Turner MW, Klein NJ, Brett SJ, Hinds CJet al., 2006, Mannose-binding lectin polymorphisms in severe sepsis: Relationship to levels, incidence, and outcome, SHOCK, Vol: 25, Pages: 88-93, ISSN: 1073-2322

Journal article

Nematy M, O'Flynn JE, Wandrag L, Brynes AE, Brett SJ, Patterson M, Ghatei MA, Bloom SR, Frost GSet al., 2005, Changes in appetite related gut hormones in intensive care unit patients: a pilot cohort study, Critical Care, Vol: 10, ISSN: 1364-8535

INTRODUCTION:The nutritional status of patients in the intensive care unit (ICU) appears to decline not only during their stay in the ICU but also after discharge from the ICU. Recent evidence suggests that gut released peptides, such as ghrelin and peptide YY (PYY) regulate the initiation and termination of meals and could play a role in the altered eating behaviour of sick patients. The aim of this study was to assess the patterns of ghrelin and PYY levels during the stay of ICU patients in hospital.METHODS:Sixteen ICU patients (60 +/- 4.7 years, body mass index (BMI) 28.1 +/- 1.7 kg/m2 (mean +/- standard error of the mean)) underwent fasting blood sample collections on days 1, 3, 5, 14, 21 and 28 of their stay at Hammersmith and Charing Cross Hospitals. Changes in appetite and biochemical and anthropometric markers of nutritional status were recorded. A comparison was made to a group of 36 healthy volunteers matched for age and BMI (54.3 +/- 2.9 years, p = 0.3; BMI 25.8 +/- 0.8 kg/m2 p = 0.2).RESULTS:Compared to healthy subjects, ICU patients exhibited a significantly lower level of ghrelin (day one 297.8 +/- 76.3 versus 827.2 +/- 78.7 pmol/l, p < 0.001) during their stay in the ICU. This tended to rise to the normal level during the last three weeks of hospital stay. Conversely, ICU patients showed a significantly higher level of PYY (day one 31.5 +/- 9.6 versus 11.3 +/- 1.0 pmol/l, p < 0.05) throughout their stay in the ICU and on the ward, with a downward trend to the normal level during the last three weeks of stay.CONCLUSIONS:Results from our study show high levels of PYY and low levels of ghrelin in ICU patients compared to healthy controls. There appears to be a relationship between the level of these gut hormones and nutritional intake.

Journal article

Brett SJ, Oates DL, Johnston C, 2005, In-service type IV cracking in a modified 9Cr (grade 91) header, Pages: 563-572

Extensive Type IV cracking has been found on branch and attachment welds on a modified 9Cr (grade 91) header after 58Khrs service. The header was a retrofit component installed on a 500MW unit in 1992. Early inspection of the header was undertaken because it had been established that a number of low nitrogen to aluminium (N:Al) ratio components had been incorporated in its construction. This had been identified as a factor common to earlier premature plant failures in this grade of steel elsewhere in the UK. This paper summarises the background to the inspection of the header, describes the distribution of cracks found, and considers the implications for other components of this type in service elsewhere.

Conference paper

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