221 results found
Brett SJ, Evans TW, 1998, Measurement of endogenous nitric oxide in the lungs of patients with the acute respiratory distress syndrome, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 157, Pages: 993-997, ISSN: 1073-449X
Brett SJ, Quinlan GJ, Mitchell J, et al., 1998, Production of nitric oxide during surgery involving cardiopulmonary bypass, CRITICAL CARE MEDICINE, Vol: 26, Pages: 272-278, ISSN: 0090-3493
Brett SJ, Evans TW, 1998, Measurement of endogenous nitric oxide in the lungs of patients with the acute respiratory distress syndrome, American Journal of Respiratory and Critical Care Medicine, Vol: 157, Pages: 993-997, ISSN: 1073-449X
Elevated levels of nitric oxide (NO) are detectable in the exhaled breath of patients suffering from a number of inflammatory lung diseases. We hypothesized that NO would be detectable in the exhaled air of patients with the acute respiratory distress syndrome (ARDS) undergoing mechanical ventilation and that the concentration would be greater than that from a control group of ventilated subjects. The concentration of NO in the lower airways of 13 patients with ARDS and 18 patients anesthetized and ventilated prior to cardiac surgery was measured by chemiluminescence. The NO concentration was 1.13 ± 0.36 (mean ± SEM) parts per billion (ppb) in the ARDS group and 5.5 ± 0.8 ppb in the control group (2 p < 0.0001). NO is detectable in the exhaled air of patients with ARDS and is at a lower concentration than in control subjects.
Curzen N, Brett S, Fox K, 1997, Concrete induced cardiac contusion, HEART, Vol: 78, Pages: 313-315, ISSN: 1355-6037
Brett SJ, Chambers J, Rosenthal M, et al., 1996, Non invasive assessment of response to inhaled nitric oxide in normal subjects, Thorax, Vol: 51, ISSN: 0040-6376
Introduction. The role of endogenous nitric oxide (NO) in the normal lung remains unclear. We investigated the response of normal subjects to the inhalation of NO using non-invasive methodology. Subjects and methods. Subjects were six non-smoking volunteers without a history of respiratory disease. Responses to inhaled NO were characterised using a respiratory mass spectrometer (AMIS 2000, Innovision, Odense, Denmark). This instrument uses a multple inert gas rebreathing technique. Rebreathing manoeuvres were performed after 5 minutes inhalation of air, NO 20 parts per million (ppm), and NO 40ppm. This manoeuvre produces values for functional residual capacity (FRC), 18carbon monoxide transfer factor (TLCO), and effective pulmonary blood flow (EPBF). Results. Results are expressed as group mean (±SEM). air NO 20ppm NO 40ppm FRC (litres) 2.88 (0.21) 3 (0.17) 2.97 (0.16) TLCO 7.45 (0.5) 7.35 (0.52) 6.81 (0.5) (mmol kPa-1 min-1) EPBF (1 min-1m-2) 2.8 (0.2) 2.67 (0.32) 2.45 (0.3) There were no significant differences detected by analysis of variance. Conclusion. Using non-invasive methodology, we were unable to detect any effects on the parameters measured. In normal subjects, the inhalation of supra-physiological doses of NO may produce no change in FRC, gas transfer or pulmonary blood flow.
Brett SJ, Evans TW, 1996, Oxide: Physiological roles and peutic implications in the lung, British Journal of Hospital Medicine, Vol: 55, Pages: 487-490, ISSN: 0007-1064
Goldrick PB, Murphy A, Brett SJ, et al., 1996, Endoscopic detection of submucosal guidewire placement during percutaneous dilatational tracheostomy, INTENSIVE CARE MEDICINE, Vol: 22, Pages: 1276-1276, ISSN: 0342-4642
Brett SJ, Evans TW, 1996, Endogenous nitric oxide in exhaled human breath - A new means of monitoring airway disease activity or another NO-NO?, CHEST, Vol: 110, Pages: 873-874, ISSN: 0012-3692
Brett SJ, Evans TW, 1996, Nitric oxide: Physiological roles and therapeutic implications in the lung, BRITISH JOURNAL OF HOSPITAL MEDICINE, Vol: 55, Pages: 487-490, ISSN: 1750-8460
Brett SJ, Gibbs JSR, Pepper JR, et al., 1996, Impairment of endothelium-dependent pulmonary vasodilation in patients with primary pulmonary hypertension, THORAX, Vol: 51, Pages: 89-91, ISSN: 0040-6376
Brett SJ, Evans TW, 1995, Inhaled vasodilator therapy in acute lung injury: first, do NO harm?, Thorax, Vol: 50, Pages: 821-823, ISSN: 0040-6376
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