Imperial College London


Faculty of MedicineDepartment of Surgery & Cancer

Professor of Critical Care



+44 (0)20 3313 4521stephen.brett Website




Hammersmith House 570Hammersmith HospitalHammersmith Campus






BibTex format

author = {Bauchmuller, K and Manson, J and Tattersall, R and Brown, M and McNamara, C and Singer, M and Brett, S},
doi = {10.1177/1751143719893865},
journal = {Journal of the Intensive Care Society},
pages = {256--268},
title = {Haemophagocytic lymphohistiocytosis in adult critical care},
url = {},
volume = {21},
year = {2020}

RIS format (EndNote, RefMan)

AB - Haemophagocytic lymphohistiocytosis (HLH) is a syndrome of severe immune dysregulation,characterised by extreme inflammation, fever, cytopaenias and organ dysfunction. HLH can betriggered by conditions such as infection, auto-immune disease and malignancy, amongst others.Both a familial and a secondary form have been described, the latter being increasinglyrecognised in adult patients with critical illness. HLH is difficult to diagnose, often underrecognised and carries a high mortality. Patients can present in a very similar fashion to sepsis andthe two syndromes can co-exist and overlap, yet HLH requires specific immunosuppressivetherapy. HLH should be actively excluded in patients with presumed sepsis who either lack a clearfocus of infection or who are not responding to energetic infection management. Elevated serumferritin is a key biomarker that may indicate the need for further investigations for HLH and canguide treatment. Early diagnosis and a multidisciplinary approach to HLH management may savelives.
AU - Bauchmuller,K
AU - Manson,J
AU - Tattersall,R
AU - Brown,M
AU - McNamara,C
AU - Singer,M
AU - Brett,S
DO - 10.1177/1751143719893865
EP - 268
PY - 2020///
SN - 1751-1437
SP - 256
TI - Haemophagocytic lymphohistiocytosis in adult critical care
T2 - Journal of the Intensive Care Society
UR -
UR -
VL - 21
ER -