Imperial College London


Faculty of MedicineDepartment of Surgery & Cancer

Professor of Critical Care



+44 (0)20 3313 4521stephen.brett Website




Hammersmith House 570Hammersmith HospitalHammersmith Campus






BibTex format

author = {Tran, LN and Patel, J and Yang, J and ONeill, C and Yin, D and Nguyen, R and Pogson, D and Deakin, C and Harris, T and Brett, S and Page, V and Parnia, S},
doi = {10.1016/j.resuscitation.2020.06.006},
journal = {Resuscitation},
pages = {85--92},
title = {The Association between post-cardiac arrest cerebral oxygenation and survival with favorable neurological outcomes: a multicenter study},
url = {},
volume = {154},
year = {2020}

RIS format (EndNote, RefMan)

AB - ObjectiveCerebral oximetry is a non-invasive system that uses near infrared spectroscopy to measure regional cerebral oxygenation (rSO2) in the frontal lobe of the brain. Post-cardiac arrest rSO2 may be associated with survival and neurological outcomes in out-of-hospital cardiac arrest patients; however, no studies have examined relationships between rSO2 and neurological outcomes following in-hospital cardiac arrest (IHCA). We tested the hypothesis that rSO2 following IHCA is associated with survival and favorable neurological outcomes.DesignProspective study from nine acute care hospital in the United States and United Kingdom.PatientsConvenience sample of IHCA patients admitted to the intensive care unit with post-cardiac arrest syndrome.InterventionsCerebral oximetry monitoring (Equanox 7600, Nonin Medical, MN, USA) during the first 48 hours after IHCA.Measurements and Main ResultsSubject’s rSO2 was calculated as the mean of collected data at different time intervals: hourly between 1-6 hour, 6-12 hr, 12-18hr, 18-24 hr and 24-48hr. Demographic data pertaining to possible confounding variables for rSO2 and primary outcome were collected. The primary outcome was survival with favorable neurological outcomes (cerebral performance scale [CPC] 1-2) vs severe neurological injury or death (CPC 3-5) at hospital discharge. Univariate and multivariate statistical analyses were performed to correlate cerebral oximetry values and other variables with the primary outcome. Among 87 studied patients, 26 (29.9%) achieved CPC1-2. A significant difference in mean rSO2 was observed during hours 1-2 after IHCA in CPC 1-2 vs CPC3-5 (73.08 vs. 66.59, p = 0.031) but not at other time intervals. There were no differences in age, Charlson comorbidity index, APACHE II scores, CPR duration, mean arterial pressure, PaO2, PaCO2, and hemoglobin levels between two groups.ConclusionsThere may be a significant physiological difference in rSO2 in
AU - Tran,LN
AU - Patel,J
AU - Yang,J
AU - ONeill,C
AU - Yin,D
AU - Nguyen,R
AU - Pogson,D
AU - Deakin,C
AU - Harris,T
AU - Brett,S
AU - Page,V
AU - Parnia,S
DO - 10.1016/j.resuscitation.2020.06.006
EP - 92
PY - 2020///
SN - 0300-9572
SP - 85
TI - The Association between post-cardiac arrest cerebral oxygenation and survival with favorable neurological outcomes: a multicenter study
T2 - Resuscitation
UR -
UR -
UR -
VL - 154
ER -