Publications
281 results found
Tan T, Brett SJ, Stokes T, 2009, Guidelines: Rehabilitation after critical illness: summary of NICE guidance, BMJ (Online), Vol: 338
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- Citations: 12
Tan T, Brett SJ, Stokes T, 2009, <i>Guidelines</i> Rehabilitation after critical illness: summary of NICE guidance, BRITISH MEDICAL JOURNAL, Vol: 338, ISSN: 0959-535X
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- Citations: 49
Chapman RJ, Templeton M, Ashworth S, et al., 2009, Long-term survival of chronic dialysis patients following survival from an episode of multiple-organ failure, CRITICAL CARE, Vol: 13, ISSN: 1364-8535
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- Citations: 18
Sevdalis N, Brett SJ, 2009, Improving care by understanding the way we work: human factors and behavioural science in the context of intensive care, CRITICAL CARE, Vol: 13, ISSN: 1466-609X
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- Citations: 28
Eisen DP, Dean MM, Boermeester MA, et al., 2008, Low serum mannose-binding lectin level increases the risk of death due to pneumococcal infection, CLINICAL INFECTIOUS DISEASES, Vol: 47, Pages: 510-516, ISSN: 1058-4838
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- Citations: 148
Griffiths JA, Brett SJ, 2008, Follow-up, CORE TOPICS IN CARDIOTHORACIC CRITICAL CARE, Editors: klein, Vuylsteke, Nashef, Publisher: CAMBRIDGE UNIV PRESS, Pages: 442-449
Nematy M, Brynes AE, Hornick PI, et al., 2007, Postprandial ghrelin suppression is exaggerated following major surgery; implications for nutritional recovery, Nutrition & Metabolism, Vol: 4, ISSN: 1743-7075
Chapman RJ, Brett SJ, 2007, Cognitive dysfunction in intensive care survivors, BRITISH JOURNAL OF HOSPITAL MEDICINE, Vol: 68, Pages: 467-469, ISSN: 1750-8460
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- Citations: 1
Price LC, Brett SJ, Howard LS, 2007, The use of vasopressors in pulmonary hypertension on the intensive care unit., Br J Hosp Med (Lond), Vol: 68, ISSN: 1750-8460
Sukantarat KT, Williamson RCN, Brett SJ, 2007, Psychological assessment of ICU survivors: a comparison between the Hospital Anxiety and Depression scale and the Depression, Anxiety and Stress scale, ANAESTHESIA, Vol: 62, Pages: 239-243, ISSN: 0003-2409
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- Citations: 72
Garner J, Brett SJ, 2007, Mechanisms of injury by explosive devices., Anesthesiol Clin, Vol: 25, Pages: 147-x, ISSN: 1932-2275
Explosive devices cause injury by four mechanisms, of which primary blast injury is the least familiar to most non-military clinicians. The pathophysiology of the various mechanisms of injury is described, and the implications for translating a knowledge of mechanism of injury to clinical management is discussed.
Sukantarat K, Greer S, Brett S, et al., 2007, Physical and psychological sequelae of critical illness, BRITISH JOURNAL OF HEALTH PSYCHOLOGY, Vol: 12, Pages: 65-74, ISSN: 1359-107X
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- Citations: 90
Allen DJ, Harvey B, Brett SJ, 2007, "FOURCRACK"-An investigation of the creep performance of advanced high alloy steel welds, International Journal of Pressure Vessels and Piping, Vol: 84, Pages: 104-113, ISSN: 0308-0161
Creep failure by "Type IV" cracking in the weld heat-affected zone (HAZ) is likely to be the life-limiting failure mechanism in high-alloy steel components for advanced power plant. A UK collaborative project, "FOURCRACK", has therefore been carried out to investigate and compare the cross-weld creep rupture performance of several casts of the advanced steels E911, P92, and P122, and the established steel P91. The experimental matrix included both stress and temperature variations while minimising the testing required to characterise the comparative performance of different welded materials. The results clarify the interplay between weld metal and HAZ failure mechanisms, the relationships between parent material and cross-weld creep strength, and the relative merits of the alternative steels. Finally, problems which arise in the assessment of cross-weld creep test data are discussed, and recommendations put forward to address the risks of biased assessment when failure can take place in different locations within the weldment. © 2006 Elsevier Ltd. All rights reserved.
Arawwawala D, Brett SJ, 2007, Clinical review: Beyond immediate survival from resuscitation long-term outcome considerations after cardiac arrest, CRITICAL CARE, Vol: 11, ISSN: 1364-8535
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- Citations: 18
Arawwawala D, Brett S, 2006, Changes to the European Resuscitation Council cardiac arrest management guidelines - A commentary, British Journal of Cardiology, Vol: 13, Pages: 425-429, ISSN: 0969-6113
The European Resuscitation Council guidelines for the management of cardiac arrest have been updated. The following commentary discusses the major changes, the evidence on which they are based and the practical issues of their introduction.
Suntharalingam G, Perry MR, Ward S, et al., 2006, Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 355, Pages: 1018-1028, ISSN: 0028-4793
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- Citations: 1470
Payne EM, Brett SJ, Laffan MA, 2006, Efficacy of recombinant activated factor VII in unselected patients with uncontrolled haemorrhage: a single centre experience, BLOOD COAGULATION & FIBRINOLYSIS, Vol: 17, Pages: 397-402, ISSN: 0957-5235
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- Citations: 8
Fong KJ, Lohn JWG, Brett SJ, et al., 2006, The 7th of July London suicide bombings - One year on, Care of the Critically Ill, Vol: 22, Pages: 53-54, ISSN: 0266-0970
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- Citations: 1
Bradlow W, Brett S, 2006, Management of pulmonary arterial hypertension, Care of the Critically Ill, Vol: 22, Pages: 57-61, ISSN: 0266-0970
Pulmonary arterial hypertension (PAH) is a rare entity with a poor prognosis. With increasing recognition, growing numbers of health care professionals, including those outside designated specialist centres, will be involved in the care of patients with PAH. This review discusses current treatment and the evidence base supporting their use. Attention is also given to future developments and the PAH patient in intensive care.
Nematy M, O'Flynn JE, Wandrag L, et al., 2006, Authors' response [2], Critical Care, Vol: 10, ISSN: 1364-8535
Tillyard A, Kuper M, Brett S, 2006, The difficulties that exist putting ethical theory into practice in critical care, Clinical Intensive Care, Vol: 17, Pages: 1-7, ISSN: 0956-3075
At a recent General Medical Council conference it was suggested by Dame Janet Smith, author of the Shipman inquiry report, that medical students should be assessed on their understanding of ethical principles (GMC Education Conference, May 9, 2005). Indeed, issues of medical ethics have recently made headline news around the world. In England, the right of a patient with progressive cerebellar ataxia to compel doctors to continued feeding for so long as he wishes is under appeal (Dyer, C. The Guardian, London, May 16th, 2005). In America, the recent death following withdrawal of feeding from Terri Schiavo, who was in a persistent vegetative state since 1990, taxed doctors, legislators and politicians up to the White House (Stolberg, SG, The New York Times, April 1, 2005). While such high profile cases arise exceptionally, critical care routinely involves ethical considerations, either implicitly or explicitly. This review describes various ethical principles commonly employed in relation to critical care, and the common problems with their application in the practice of managing the critically ill patient.
Terblanche M, Brett SJ, 2006, Systemic inflammatory response syndrome and complications after surgery, JOURNAL OF CRITICAL CARE, Vol: 21, Pages: 53-55, ISSN: 0883-9441
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- Citations: 1
Nematy M, O'Flynn JE, Wandrag L, et al., 2006, Changes in appetite related gut hormones in intensive care unit patients: a pilot cohort study, Critical care (London, England), Vol: 10
METHODS: Sixteen ICU patients (60 +/- 4.7 years, body mass index (BMI) 28.1 +/- 1.7 kg/m2 (mean +/- standard error of the mean)) underwent fasting blood sample collections on days 1, 3, 5, 14, 21 and 28 of their stay at Hammersmith and Charing Cross Hospitals. Changes in appetite and biochemical and anthropometric markers of nutritional status were recorded. A comparison was made to a group of 36 healthy volunteers matched for age and BMI (54.3 +/- 2.9 years, p = 0.3; BMI 25.8 +/- 0.8 kg/m2 p = 0.2). RESULTS: Compared to healthy subjects, ICU patients exhibited a significantly lower level of ghrelin (day one 297.8 +/- 76.3 versus 827.2 +/- 78.7 pmol/l, p < 0.001) during their stay in the ICU. This tended to rise to the normal level during the last three weeks of hospital stay. Conversely, ICU patients showed a significantly higher level of PYY (day one 31.5 +/- 9.6 versus 11.3 +/- 1.0 pmol/l, p < 0.05) throughout their stay in the ICU and on the ward, with a downward trend to the normal level during the last three weeks of stay. CONCLUSIONS: Results from our study show high levels of PYY and low levels of ghrelin in ICU patients compared to healthy controls. There appears to be a relationship between the level of these gut hormones and nutritional intake. INTRODUCTION: The nutritional status of patients in the intensive care unit (ICU) appears to decline not only during their stay in the ICU but also after discharge from the ICU. Recent evidence suggests that gut released peptides, such as ghrelin and peptide YY (PYY) regulate the initiation and termination of meals and could play a role in the altered eating behaviour of sick patients. The aim of this study was to assess the patterns of ghrelin and PYY levels during the stay of ICU patients in hospital.
Grover M, Talwalkar S, Casbard A, et al., 2006, Silent myocardial ischaemia and haemoglobin concentration: a randomized controlled trial of transfusion strategy in lower limb arthroplasty, VOX SANGUINIS, Vol: 90, Pages: 105-112, ISSN: 0042-9007
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- Citations: 81
Kalbag A, Kotyra Z, Richards M, et al., 2006, Long-term survival and residual hazard after in-hospital cardiac arrest, RESUSCITATION, Vol: 68, Pages: 79-83, ISSN: 0300-9572
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- Citations: 13
Gordon AC, Waheed U, Hansen TK, et al., 2006, Mannose-binding lectin polymorphisms in severe sepsis: Relationship to levels, incidence, and outcome, SHOCK, Vol: 25, Pages: 88-93, ISSN: 1073-2322
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- Citations: 77
Hudson SJ, Brett SJ, 2006, Heterotopic ossification - a long-term consequence of prolonged immobility, CRITICAL CARE, Vol: 10, ISSN: 1466-609X
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- Citations: 16
Nematy M, Brynes AE, Hornick PI, et al., 2006, Postprandial ghrelin suppression is exaggerated following major surgery; implications for nutritional recovery., PROCEEDINGS OF THE NUTRITION SOCIETY, Vol: 65, Pages: 63A-63A, ISSN: 0029-6651
Nematy M, O'Flynn JE, Wandrag L, et al., 2005, Changes in appetite related gut hormones in intensive care unit patients: a pilot cohort study, Critical Care, Vol: 10, ISSN: 1364-8535
INTRODUCTION:The nutritional status of patients in the intensive care unit (ICU) appears to decline not only during their stay in the ICU but also after discharge from the ICU. Recent evidence suggests that gut released peptides, such as ghrelin and peptide YY (PYY) regulate the initiation and termination of meals and could play a role in the altered eating behaviour of sick patients. The aim of this study was to assess the patterns of ghrelin and PYY levels during the stay of ICU patients in hospital.METHODS:Sixteen ICU patients (60 +/- 4.7 years, body mass index (BMI) 28.1 +/- 1.7 kg/m2 (mean +/- standard error of the mean)) underwent fasting blood sample collections on days 1, 3, 5, 14, 21 and 28 of their stay at Hammersmith and Charing Cross Hospitals. Changes in appetite and biochemical and anthropometric markers of nutritional status were recorded. A comparison was made to a group of 36 healthy volunteers matched for age and BMI (54.3 +/- 2.9 years, p = 0.3; BMI 25.8 +/- 0.8 kg/m2 p = 0.2).RESULTS:Compared to healthy subjects, ICU patients exhibited a significantly lower level of ghrelin (day one 297.8 +/- 76.3 versus 827.2 +/- 78.7 pmol/l, p < 0.001) during their stay in the ICU. This tended to rise to the normal level during the last three weeks of hospital stay. Conversely, ICU patients showed a significantly higher level of PYY (day one 31.5 +/- 9.6 versus 11.3 +/- 1.0 pmol/l, p < 0.05) throughout their stay in the ICU and on the ward, with a downward trend to the normal level during the last three weeks of stay.CONCLUSIONS:Results from our study show high levels of PYY and low levels of ghrelin in ICU patients compared to healthy controls. There appears to be a relationship between the level of these gut hormones and nutritional intake.
Allen DJ, Harvey B, Brett SJ, 2005, "FOURCRACK" - An investigation of the creep performance of advanced high alloy steel welds, Pages: 772-782
Creep failure by "Type IV" cracking in the weld heat-affected zone (HAZ) is likely to be the life-limiting failure mechanism in high alloy steel components for advanced power plant. A UK collaborative project, "FOURCRACK", has therefore been carried out to investigate and compare the cross-weld creep rupture performance of several casts of the advanced steels E911, P92, and P122, and the established steel P91. The experimental matrix included both stress and temperature variations while minimising the testing required to characterise the comparative performance of different welded materials. The results clarify the interplay between weld metal and HAZ failure mechanisms, the relationships between parent material and cross-weld creep strength, and the relative merits of the alternative steels. Finally, problems which arise in the assessment of cross-weld creep test data are discussed, and recommendations put forward to address the risks of biased assessment when failure can take place in different locations within the weldment.
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