Imperial College London
Alternate

ProfessorStephenBrett

Faculty of Medicine, Department of Surgery & Cancer

Professor of Critical Care
 
 
 
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Contact

 

+44 (0)20 3313 4521stephen.brett Website

 
 
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Location

 

Hammersmith House 570Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bauchmuller:2020:10.1177/1751143719893865,
author = {Bauchmuller, K and Manson, J and Tattersall, R and Brown, M and McNamara, C and Singer, M and Brett, S},
doi = {10.1177/1751143719893865},
journal = {Journal of the Intensive Care Society},
pages = {256--268},
title = {Haemophagocytic lymphohistiocytosis in adult critical care},
url = {http://dx.doi.org/10.1177/1751143719893865},
volume = {21},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Haemophagocytic lymphohistiocytosis (HLH) is a syndrome of severe immune dysregulation,characterised by extreme inflammation, fever, cytopaenias and organ dysfunction. HLH can betriggered by conditions such as infection, auto-immune disease and malignancy, amongst others.Both a familial and a secondary form have been described, the latter being increasinglyrecognised in adult patients with critical illness. HLH is difficult to diagnose, often underrecognised and carries a high mortality. Patients can present in a very similar fashion to sepsis andthe two syndromes can co-exist and overlap, yet HLH requires specific immunosuppressivetherapy. HLH should be actively excluded in patients with presumed sepsis who either lack a clearfocus of infection or who are not responding to energetic infection management. Elevated serumferritin is a key biomarker that may indicate the need for further investigations for HLH and canguide treatment. Early diagnosis and a multidisciplinary approach to HLH management may savelives.
AU  - Bauchmuller,K
AU  - Manson,J
AU  - Tattersall,R
AU  - Brown,M
AU  - McNamara,C
AU  - Singer,M
AU  - Brett,S
DO  - 10.1177/1751143719893865
EP  - 268
PY  - 2020///
SN  - 1751-1437
SP  - 256
TI  - Haemophagocytic lymphohistiocytosis in adult critical care
T2  - Journal of the Intensive Care Society
UR  - http://dx.doi.org/10.1177/1751143719893865
UR  - http://hdl.handle.net/10044/1/74854
VL  - 21
ER  -
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