Imperial College London
Alternate

ProfessorStephenBrett

Faculty of Medicine, Department of Surgery & Cancer

Professor of Critical Care
 
 
 
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Contact

 

+44 (0)20 3313 4521stephen.brett Website

 
 
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Location

 

Hammersmith House 570Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Glampson:2021:10.2196/30010,
author = {Glampson, B and Brittain, J and Kaura, A and Mulla, A and Mercuri, L and Brett, S and Aylin, P and tessa, S and goodman, I and Redhead, J and kavitha, S and Mayer, E},
doi = {10.2196/30010},
journal = {JMIR Public Health and Surveillance},
pages = {1--17},
title = {North West London Covid-19 Vaccination Programme: Real-world evidence for Vaccine uptake and effectiveness: Retrospective Cohort Study},
url = {http://dx.doi.org/10.2196/30010},
volume = {7},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background:On March 11, 2020 the World Health Organisation declared the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causing Coronavirus Disease 2019 (COVID-19) syndrome, as a pandemic. The UK mass vaccination programme commenced on December 08, 2020 vaccinating groups of the population deemed to be most vulnerable to severe COVID-19 infection.Objective:To assess the early vaccine administration coverage and outcome data across an integrated care system in North West London (NWL), leveraging a unique population-level care dataset. Vaccine effectiveness of a single dose of the Oxford/Astrazeneca and Pfizer/BioNtech vaccines were compared.Methods:A retrospective cohort study identified 2,183,939 individuals eligible for COVID-19 vaccination between December 08, 2020 and February 24, 2021 within a primary, secondary and community care integrated care dataset. These data were used to assess vaccination hesitancy across ethnicity, gender and socio-economic deprivation measures (Pearson Product-Moment Correlations); investigated COVID-19 transmission related to vaccination hubs; and assessed the early effectiveness of COVID-19 vaccination (after a single dose) using time to event analyses with multivariable Cox regression analysis to investigate if vaccination independently predicted positive SARS-CoV-2 in those vaccinated compared to those unvaccinated.Results: In the study 5.88% (24,332/413,919) of individuals declined and did not receive a vaccination. Black or Black British individuals had the highest rate of declining a vaccine at 16.14% (4,337/26,870). There was a strong negative association between socio-economic deprivation and rate of declining vaccination (r=-0.94, P=.002) with 13.5% (1980/14571) of individuals declining vaccination in the most deprived areas compared to 0.98% (869/9609) in the least. In the first six days after vaccination 344 of 389587 individuals tested positive for SARS-CoV-2 (0.09%). The rate increased to 0.13% (525/389,243)
AU  - Glampson,B
AU  - Brittain,J
AU  - Kaura,A
AU  - Mulla,A
AU  - Mercuri,L
AU  - Brett,S
AU  - Aylin,P
AU  - tessa,S
AU  - goodman,I
AU  - Redhead,J
AU  - kavitha,S
AU  - Mayer,E
DO  - 10.2196/30010
EP  - 17
PY  - 2021///
SN  - 2369-2960
SP  - 1
TI  - North West London Covid-19 Vaccination Programme: Real-world evidence for Vaccine uptake and effectiveness: Retrospective Cohort Study
T2  - JMIR Public Health and Surveillance
UR  - http://dx.doi.org/10.2196/30010
UR  - https://publichealth.jmir.org/2021/9/e30010
UR  - http://hdl.handle.net/10044/1/90252
VL  - 7
ER  -
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