Imperial College London
Alternate

ProfessorSylviaRichardson

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 3336sylvia.richardson Website

 
 
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Assistant

 

Miss Sonia Kharbotli +44 (0)20 7594 3319

 
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Location

 

161Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

150 results found

Geneletti S, Richardson S, Best N, 2009, Adjusting for selection bias in retrospective, case-control studies, BIOSTATISTICS, Vol: 10, Pages: 17-31, ISSN: 1465-4644

Journal article

Molitor N-T, Best N, Jackson C, Richardson Set al., 2009, Using Bayesian graphical models to model biases in observational studies and to combine multiple sources of data: application to low birth weight and water disinfection by-products, JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES A-STATISTICS IN SOCIETY, Vol: 172, Pages: 615-637, ISSN: 0964-1998

Journal article

Broet P, Tan P, Alifano M, Camilleri-Broet S, Richardson Set al., 2009, Finding exclusively deleted or amplified genomic areas in lung cancer adenocarcinomas using a novel chromosomal pattern analysis, BMC Medical Genomics, Vol: 2

Journal article

Blangiardo M, Richardson S, 2008, A Bayesian calibration model for combining different pre-processing methods in Affymetrix chips, BMC BIOINFORMATICS, Vol: 9, ISSN: 1471-2105

Journal article

Jackson CH, Richardson S, Best NG, 2008, Studying place effects on health by synthesising individual and area-level outcomes, SOCIAL SCIENCE & MEDICINE, Vol: 67, Pages: 1995-2006, ISSN: 0277-9536

Journal article

Bickel P, Buehlmann P, Yao Q, Samworth R, Hall P, Titterington DM, Xue J-H, Anagnostopoulos C, Tasoullis DK, Zhang W, Xia Y, Johnstone IM, Richardson S, Bottolo L, Kent JT, Adragni K, Cook RD, Gather U, Guddat C, Greenshtein E, James GM, Radchenko P, Leng C, Wang H, Levina E, Zhu J, Li R, Liu Y, Longford NT, Luo W, Baxter PD, Taylor CC, Marron JS, Morris JS, Robert CP, Yu K, Zhang C-H, Zhang HH, Zhou HH, Lin X, Zou Het al., 2008, Sure independence screening for ultrahigh dimensional feature space Discussion, Publisher: WILEY

Other

Abellan JJ, Richardson S, Best N, 2008, Use of space-time models to investigate the stability of patterns of disease, ENVIRONMENTAL HEALTH PERSPECTIVES, Vol: 116, Pages: 1111-1119, ISSN: 0091-6765

Journal article

Jackson C, Best N, Richardson S, 2008, Hierarchical related regression for combining aggregate and individual data in studies of socio-economic disease risk factors, JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES A-STATISTICS IN SOCIETY, Vol: 171, Pages: 159-178, ISSN: 0964-1998

Journal article

Zucknick M, Richardson S, Stronach EA, 2008, Comparing the characteristics of gene expression profiles derived by univariate and multivariate classification methods, STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY, Vol: 7, ISSN: 2194-6302

Journal article

Jarup L, Morris S, Richardson S, Briggs D, Cobley N, de Hoogh C, Gorog K, Elliott Pet al., 2007, Down syndrome in births near landfill sites, PRENATAL DIAGNOSIS, Vol: 27, Pages: 1191-1196, ISSN: 0197-3851

Journal article

Ratmann O, Jorgensen O, Hinkley T, Stumpf M, Richardson S, Wiuf Cet al., 2007, Using likelihood-free inference to compare evolutionary dynamics of the protein networks of H. pylori and P. falciparum, PLOS Computational Biology, Vol: 3, ISSN: 1553-734X

Gene duplication with subsequent interaction divergence is one of the primary driving forces in the evolution of genetic systems. Yet little is known about the precise mechanisms and the role of duplication divergence in the evolution of protein networks from the prokaryote and eukaryote domains. We developed a novel, model-based approach for Bayesian inference on biological network data that centres on approximate Bayesian computation, or likelihood-free inference. Instead of computing the intractable likelihood of the protein network topology, our method summarizes key features of the network and, based on these, uses a MCMC algorithm to approximate the posterior distribution of the model parameters. This allowed us to reliably fit a flexible mixture model that captures hallmarks of evolution by gene duplication and subfunctionalization to protein interaction network data of Helicobacter pylori and Plasmodium falciparum. The 80% credible intervals for the duplication–divergence component are [0.64, 0.98] for H. pylori and [0.87, 0.99] for P. falciparum. The remaining parameter estimates are not inconsistent with sequence data. An extensive sensitivity analysis showed that incompleteness of PIN data does not largely affect the analysis of models of protein network evolution, and that the degree sequence alone barely captures the evolutionary footprints of protein networks relative to other statistics. Our likelihood-free inference approach enables a fully Bayesian analysis of a complex and highly stochastic system that is otherwise intractable at present. Modelling the evolutionary history of PIN data, it transpires that only the simultaneous analysis of several global aspects of protein networks enables credible and consistent inference to be made from available datasets. Our results indicate that gene duplication has played a larger part in the network evolution of the eukaryote than in the prokaryote, and suggests that single gene duplications with immedia

Journal article

Turro E, Bochkina N, Hein A-MK, Richardson Set al., 2007, BGX: a Bioconductor package for the Bayesian integrated analysis of Affymetrix GeneChips, BMC BIOINFORMATICS, Vol: 8, ISSN: 1471-2105

Journal article

Abellan JJ, Fecht D, Best N, Richardson S, Briggs DJet al., 2007, Bayesian analysis of the multivariate geographical distribution of the socio-economic environment in England, 3rd International Workshop on Spatio-Temporal Modelling, Publisher: WILEY, Pages: 745-758, ISSN: 1180-4009

Conference paper

Abellan JJ, Richardson S, Best N, 2007, Spatial versus spatiotemporal disease mapping, 19th Annual Conference of the International-Society-for-Environmental-Epidemiology, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S111-S111, ISSN: 1044-3983

Conference paper

Barton SJ, Richardson S, Perkins DN, Bellahn I, Bryant TN, Whittaker JCet al., 2007, Using statistical models to identify factors that have a role in defining the abundance of ions produced by tandem MS, ANALYTICAL CHEMISTRY, Vol: 79, Pages: 5601-5607, ISSN: 0003-2700

Journal article

Zucknick M, Holmes C, Richardson S, 2007, MCMC methods for bayesian variable selection in large-scale genomic applications, 35th European Mathematical Genetics Meeting, Publisher: BLACKWELL PUBLISHING, Pages: 558-559, ISSN: 0003-4800

Conference paper

Lewin A, Bochkina N, Richardson S, 2007, Fully bayesian mixture model for differential gene expression: Simulations and model checks, STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY, Vol: 6, ISSN: 2194-6302

Journal article

Blangiardo M, Richardson S, 2007, Statistical tools for synthesizing lists of differentially expressed features in related experiments, GENOME BIOLOGY, Vol: 8, ISSN: 1474-760X

Journal article

Bochkina N, Richardson S, 2007, Tail posterior probability for Inference in Pairwise and Multiclass Gene Expression Data, Biometrics

Journal article

Jarup L, Morris S, Richardson S, Briggs D, Cobley N, Dehoogh C, Elliott Pet al., 2006, Down's syndrome in births near landfill sites, EPIDEMIOLOGY, Vol: 17, Pages: S348-S348, ISSN: 1044-3983

Journal article

Hein A-MK, Richardson S, 2006, A powerful method for detecting differentially expressed genes from GeneChip arrays that does not require replicates, BMC BIOINFORMATICS, Vol: 7, ISSN: 1471-2105

Journal article

Jackson C, Best N, Richardson S, 2006, Improving ecological inference using individual-level data, STATISTICS IN MEDICINE, Vol: 25, Pages: 2136-2159, ISSN: 0277-6715

Journal article

Schischmanoff PO, Naccache J-M, Carrere A, Richardson S, Kambouchner M, Raphael M, Valeyre D, Fagard Ret al., 2006, Progressive pulmonary sarcoidosis is associated with over-expression of TYK2 and p21<SUP>waf1/CiP1</SUP>, SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES, Vol: 23, Pages: 101-107, ISSN: 1124-0490

Journal article

Broët P, Richardson S, 2006, Detection of gene copy number changes in CGH microarrays using a spatially correlated mixture model, BIOINFORMATICS, Vol: 22, Pages: 911-918, ISSN: 1367-4803

Journal article

Parry S, Hadaschik D, Blancher C, Kumaran MK, Bochkina N, Morris HR, Richardson S, Aitman TJ, Gauguier D, Siddle K, Scott J, Dell Aet al., 2006, Glycomics investigation into insulin action, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Vol: 1760, Pages: 652-668, ISSN: 0304-4165

Journal article

Lewin A, Richardson S, Marshall C, Glazier A, Aitman Tet al., 2006, Bayesian modeling of differential gene expression, BIOMETRICS, Vol: 62, Pages: 1-9, ISSN: 0006-341X

Journal article

Richardson S, Abellan JJ, Best N, 2006, Bayesian spatio-temporal analysis of joint patterns of male and female lung cancer risks in Yorkshire (UK), STATISTICAL METHODS IN MEDICAL RESEARCH, Vol: 15, Pages: 385-407, ISSN: 0962-2802

Journal article

Richardson S, 2005, Statistics for studies of human welfare - Discussion, INTERNATIONAL STATISTICAL REVIEW, Vol: 73, Pages: 263-264, ISSN: 0306-7734

Journal article

Hein AMK, Richardson S, Causton HC, Ambler GK, Green PJet al., 2005, BGX: a fully Bayesian integrated approach to the analysis of Affymetrix GeneChip data, BIOSTATISTICS, Vol: 6, Pages: 349-373, ISSN: 1465-4644

Journal article

Seaman SR, Richardson S, 2005, Equivalence of prospective and retrospective models in the Bayesian analysis of case-control studies (vol 91, pg 15, 2004), BIOMETRIKA, Vol: 92, Pages: 505-505, ISSN: 0006-3444

Journal article

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