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@article{Mattei:2016:10.1136/oemed-2015-103177,
author = {Mattei, F and Liverani, S and Guida, F and Matrat, M and Cenee, S and Azizi, L and Menvielle, G and Sanchez, M and Pilorget, C and Lapotre-Ledoux, B and Luce, D and Richardson, S and Stucker, I},
doi = {10.1136/oemed-2015-103177},
journal = {Occupational and Environmental Medicine},
pages = {368--377},
title = {Multidimensional analysis of the effect of occupational exposure to organic solvents on lung cancer risk: the ICARE study},
url = {http://dx.doi.org/10.1136/oemed-2015-103177},
volume = {73},
year = {2016}
}

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TY  - JOUR
AB  - Background The association between lung cancer and occupational exposure to organic solvents is discussed. Since different solvents are often used simultaneously, it is difficult to assess the role of individual substances.Objectives The present study is focused on an in-depth investigation of the potential association between lung cancer risk and occupational exposure to a large group of organic solvents, taking into account the well-known risk factors for lung cancer, tobacco smoking and occupational exposure to asbestos.Methods We analysed data from the Investigation of occupational and environmental causes of respiratory cancers (ICARE) study, a large French population-based case–control study, set up between 2001 and 2007. A total of 2276 male cases and 2780 male controls were interviewed, and long-life occupational history was collected. In order to overcome the analytical difficulties created by multiple correlated exposures, we carried out a novel type of analysis based on Bayesian profile regression.Results After analysis with conventional logistic regression methods, none of the 11 solvents examined were associated with lung cancer risk. Through a profile regression approach, we did not observe any significant association between solvent exposure and lung cancer. However, we identified clusters at high risk that are related to occupations known to be at risk of developing lung cancer, such as painters.Conclusions Organic solvents do not appear to be substantial contributors to the occupational risk of lung cancer for the occupations known to be at risk.
AU  - Mattei,F
AU  - Liverani,S
AU  - Guida,F
AU  - Matrat,M
AU  - Cenee,S
AU  - Azizi,L
AU  - Menvielle,G
AU  - Sanchez,M
AU  - Pilorget,C
AU  - Lapotre-Ledoux,B
AU  - Luce,D
AU  - Richardson,S
AU  - Stucker,I
DO  - 10.1136/oemed-2015-103177
EP  - 377
PY  - 2016///
SN  - 1470-7926
SP  - 368
TI  - Multidimensional analysis of the effect of occupational exposure to organic solvents on lung cancer risk: the ICARE study
T2  - Occupational and Environmental Medicine
UR  - http://dx.doi.org/10.1136/oemed-2015-103177
UR  - http://hdl.handle.net/10044/1/40390
VL  - 73
ER  -

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