Publications
97 results found
Andrew T, Aviv A, Falchi M, et al., 2006, Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs, Am.J.Hum.Genet., Vol: 78, Pages: 480-486, ISSN: 0002-9297
Telomeres play a central role in cellular senescence and cancer pathobiology and are associated with age-related diseases such as atherosclerosis and dementia. Telomere length varies between individuals of the same age, is influenced by DNA-damaging factors such as oxidative stress, and is heritable. We performed a quantitative-trait linkage analysis using an approximate 10-cM genomewide map for mean leukocyte terminal-restriction fragment (TRF) lengths measured by Southern blotting, in 2,050 unselected women aged 18-80 years, comprising 1,025 complete dizygotic twin pairs. Heritability of mean batch-adjusted TRF was 36% (95% confidence interval [CI] 18%-48%), with a large common environmental effect of 49% (95% CI 40%-58%). Significant linkage was observed on chromosome 14 (LOD 3.9) at 14q23.2, and suggestive linkage at 10q26.13 (LOD 2.4) and 3p26.1 (LOD 2.7). This is the first report of loci, mapped in a sample of healthy individuals, that influence mean telomere variation in humans.
Falchi M, Andrew T, Snieder H, et al., 2005, Identification of QTLs for serum lipid levels in a female sib-pair cohort: a novel application to improve the power of two-locus linkage analysis, HUMAN MOLECULAR GENETICS, Vol: 14, Pages: 2971-2979, ISSN: 0964-6906
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- Citations: 11
Valdes AM, Andrew T, Gardner JP, et al., 2005, Obesity, cigarette smoking, and telomere length in women, LANCET, Vol: 366, Pages: 662-664, ISSN: 0140-6736
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- Citations: 1047
Ng MYM, Andrew T, Spector TD, et al., 2005, Linkage to the <i>FOXC2</i> region of chromosome 16 for varicose veins in otherwise healthy, unselected sibling pairs, JOURNAL OF MEDICAL GENETICS, Vol: 42, Pages: 235-239, ISSN: 0022-2593
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- Citations: 38
Andrew T, Antioniades L, Scurrah KJ, et al., 2005, Risk of wrist fracture in women is heritable and is influenced by genes that are largely independent of those influencing BMD, JOURNAL OF BONE AND MINERAL RESEARCH, Vol: 20, Pages: 67-74, ISSN: 0884-0431
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- Citations: 91
de Lange M, Spector TD, Andrew T, 2004, Genome-wide scan for blood pressure suggests linkage to chromosome 11, and replication of loci on 16, 17, and 22, HYPERTENSION, Vol: 44, Pages: 872-877, ISSN: 0194-911X
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- Citations: 34
Wilson SG, Reed PW, Andrew T, et al., 2004, Fine mapping provides further evidence of linkage for bone mineral density to 3p21., 26th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research, Publisher: AMER SOC BONE & MINERAL RES, Pages: S380-S380, ISSN: 0884-0431
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- Citations: 1
Andrew T, Macgregor AJ, 2004, Genes and osteoporosis., Curr Osteoporos Rep, Vol: 2, Pages: 79-89, ISSN: 1544-1873
Genes play an important role in the development of osteoporosis. Twin and family studies have consistently shown that peak bone mass, ultrasound properties of bone, skeletal geometry, bone turnover, and fracture are heritable. Yet, as we report in this paper, few candidate genes have been implicated without ambiguity. Osteoporosis is thought to be a polygenic disorder, determined by multiple genes and environmental risk factors, each with small to modest effect on bone mass and fracture. Here we argue that future success in finding genes is only possible with improved study design and the use of more rigorous analytic approaches that are now becoming available.
Hammond CJ, Andrew T, Mak YT, et al., 2004, A susceptibility locus for myopia in the normal population is linked to the <i>PAX6</i> gene region on chromosome 11:: A genomewide scan of dizygotic twins, AMERICAN JOURNAL OF HUMAN GENETICS, Vol: 75, Pages: 294-304, ISSN: 0002-9297
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- Citations: 172
MacGregor AJ, Andrew T, Sambrook PN, et al., 2004, Structural, psychological, and genetic influences on low back and neck pain: A study of adult female twins, ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH, Vol: 51, Pages: 160-167, ISSN: 0004-3591
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- Citations: 196
Hammond CJ, Andrew T, Mak YT, et al., 2004, Linkage of myopia to PAX6 in an unselected twin sample, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Pages: U910-U910, ISSN: 0146-0404
Wilson SG, Reed PW, Andrew T, et al., 2004, A genome-screen of a large twin cohort reveals linkage for quantitative ultrasound of the calcaneus to 2q33-37 and 4q12-21, JOURNAL OF BONE AND MINERAL RESEARCH, Vol: 19, Pages: 270-277, ISSN: 0884-0431
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- Citations: 32
Barber MJ, Cordell HJ, MacGregor AJ, et al., 2004, Gamma regression improves Haseman-Elston and variance components linkage analysis for sib-pairs, GENETIC EPIDEMIOLOGY, Vol: 26, Pages: 97-107, ISSN: 0741-0395
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- Citations: 20
Hammond CJ, Andrew T, Barber MJ, et al., 2003, A genome-wide screen for myopia susceptibility loci in twins, including a replicate sample, Annual Meeting of the American-Society-of-Human-Genetics, Publisher: UNIV CHICAGO PRESS, Pages: 491-491, ISSN: 0002-9297
de Lange M, Andrew T, Snieder H, et al., 2003, Combined tests of linkage and association of 4 SNPs in the FXIII A-subunit gene to FXIII activity levels., Annual Meeting of the American-Society-of-Human-Genetics, Publisher: UNIV CHICAGO PRESS, Pages: 369-369, ISSN: 0002-9297
Andrew T, Barber MJ, Swaminathan R, et al., 2003, Genome-screen of a healthy cohort of twin pairs reveals linkage for bone metabolism markers to chromosomes 1, 12, 17 and 19., Annual Meeting of the American-Society-of-Human-Genetics, Publisher: UNIV CHICAGO PRESS, Pages: 496-496, ISSN: 0002-9297
Evans A, van Baal GCM, McCarron P, et al., 2003, The Genetics of Coronary Heart Disease: The Contribution of Twin Studies, Twin Research, Vol: 6, Pages: 432-441, ISSN: 1369-0523
Knapp KM, Andrew T, MacGregor AJ, et al., 2003, An investigation of unique and shared gene effects on speed of sound and bone density using axial transmission quantitative ultrasound and DXA in twins, JOURNAL OF BONE AND MINERAL RESEARCH, Vol: 18, Pages: 1525-1530, ISSN: 0884-0431
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- Citations: 27
Antoniades L, MacGregor AJ, Andrew T, et al., 2003, Association of birth weight with osteoporosis and osteoarthritis in adult twins, RHEUMATOLOGY, Vol: 42, Pages: 791-796, ISSN: 1462-0324
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- Citations: 86
Hammond CJ, Barber MJ, Andrew T, et al., 2003, Identification of possible myopia susceptibility loci using a genome-wide screen in an unselected sample of non-identical twins, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology, Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Pages: U333-U333, ISSN: 0146-0404
de Lange M, Snieder H, Ariëns RAS, et al., 2003, The relation between insulin resistance and hemostasis:: Pleiotropic genes and common environment, TWIN RESEARCH, Vol: 6, Pages: 152-161, ISSN: 1369-0523
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- Citations: 20
Andrew T, Mak YT, Reed P, et al., 2002, Linkage and association for bone mineral density and heel ultrasound measurements with a simple tandem repeat polymorphism near the osteocalcin gene in female dizygotic twins, OSTEOPOROSIS INTERNATIONAL, Vol: 13, Pages: 745-754, ISSN: 0937-941X
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- Citations: 16
Andrew T, Hart DJ, Snieder H, et al., 2001, Are Twins and Singletons Comparable? A Study of Disease-related and Lifestyle Characteristics in Adult Women, Twin Research, Vol: 4, Pages: 464-477, ISSN: 1369-0523
Andrew T, Hart DJ, Snieder H, et al., 2001, Are twins and singletons comparable? A study of disease-related and lifestyle characteristics in adult women., Twin Res, Vol: 4, Pages: 464-477, ISSN: 1369-0523
The classic twin study is sometimes described as "the perfect natural experiment" for the investigation of the aetiology of complex disease, but assumptions of the twin design need to be empirically tested if their results are to be considered unbiased and representative of singleton populations. In this study comparisons of disease and prevalence of lifestyle characteristics have been made between twin participants in the St Thomas' Hospital UK adult twin registry, the largest twin volunteer register in the UK for the study of diseases of ageing, and a parallel population-based study of singleton women. The only differences found were for weight, where monozygotic (MZ) twins were lighter and had a smaller variance than dizygotic (DZ) twins and singletons. For the other variables studied, volunteer twins were not found to differ from age-matched singleton women in distribution or prevalence of: bone mineral density, osteoarthritis, blood pressure, hypertensive drug use, height, history of hysterectomy and ovariectomy, menopausal status and current alcohol and overall tobacco consumption. We conclude that the results of twin studies can be generalised to singleton populations for these measures and disease outcomes.
Prescott Q, Hammond CJ, Andrew T, et al., 2001, An analysis of the influence of candidate genes on the refractive error of female DZ twins., AMERICAN JOURNAL OF HUMAN GENETICS, Vol: 69, Pages: 536-536, ISSN: 0002-9297
MacGregor AJ, Antoniades L, Andrew T, et al., 2001, Genetic expression in osteoarthritis is joint specific not generalized: Evidence from a radiographic study of twins, ARTHRITIS AND RHEUMATISM, Vol: 44, Pages: S270-S270, ISSN: 0004-3591
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- Citations: 1
Antoniades L, MacGregor AJ, Andrew T, et al., 2001, Association of birth weight with osteoporosis and osteoarthritis in adult twins., ARTHRITIS AND RHEUMATISM, Vol: 44, Pages: S226-S226, ISSN: 0004-3591
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- Citations: 1
Hunter DJ, de Lange M, Andrew T, et al., 2001, Genetic variation in bone mineral density and calcaneal ultrasound: A study of the influence of menopause using female twins, OSTEOPOROSIS INTERNATIONAL, Vol: 12, Pages: 406-411, ISSN: 0937-941X
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- Citations: 59
MacGregor AJ, Antoniades L, Matson M, et al., 2000, The genetic contribution to radiographic hip osteoarthritis in women - Results of a classic twin study, ARTHRITIS AND RHEUMATISM, Vol: 43, Pages: 2410-2416, ISSN: 0004-3591
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- Citations: 118
Hunter D, Major P, Arden N, et al., 2000, A randomized controlled trial of vitamin D supplementation on preventing postmenopausal bone loss and modifying bone metabolism using identical twin pairs, JOURNAL OF BONE AND MINERAL RESEARCH, Vol: 15, Pages: 2276-2283, ISSN: 0884-0431
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- Citations: 71
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