Imperial College London
Alternate

Dr Toby Andrew

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 0968t.andrew

 
 
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Location

 

ICTEM 526ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ikram:2010:10.1371/journal.pgen.1001184,
author = {Ikram, MK and Sim, X and Jensen, RA and Cotch, MF and Hewitt, AW and Ikram, MA and Wang, JJ and Klein, R and Klein, BE and Breteler, MM and Cheung, N and Liew, G and Mitchell, P and Uitterlinden, AG and Rivadeneira, F and Hofman, A and de, Jong PT and van, Duijn CM and Kao, L and Cheng, CY and Smith, AV and Glazer, NL and Lumley, T and McKnight, B and Psaty, BM and Jonasson, F and Eiriksdottir, G and Aspelund, T and Global, BPgen Consortium and Harris, TB and Launer, LJ and Taylor, KD and Li, X and Iyengar, SK and Xi, Q and Sivakumaran, TA and Mackey, DA and Macgregor, S and Martin, NG and Young, TL and Bis, JC and Wiggins, KL and Heckbert, SR and Hammond, CJ and Andrew, T and Fahy, S and Attia, J and Holliday, EG and Scott, RJ and Islam, FM and Rotter, JI and McAuley, AK and Boerwinkle, E and Tai, ES and Gudnason, V and Siscovick, DS and Vingerling, JR and Wong, TY},
doi = {10.1371/journal.pgen.1001184},
journal = {PLOS Genetics},
title = {Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo.},
url = {http://dx.doi.org/10.1371/journal.pgen.1001184},
volume = {6},
year = {2010}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - There is increasing evidence that the microcirculation plays an important role in the pathogenesis of cardiovascular diseases. Changes in retinal vascular caliber reflect early microvascular disease and predict incident cardiovascular events. We performed a genome-wide association study to identify genetic variants associated with retinal vascular caliber. We analyzed data from four population-based discovery cohorts with 15,358 unrelated Caucasian individuals, who are members of the Cohort for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, and replicated findings in four independent Caucasian cohorts (n = 6,652). All participants had retinal photography and retinal arteriolar and venular caliber measured from computer software. In the discovery cohorts, 179 single nucleotide polymorphisms (SNP) spread across five loci were significantly associated (p<5.0×10(-8)) with retinal venular caliber, but none showed association with arteriolar caliber. Collectively, these five loci explain 1.0%-3.2% of the variation in retinal venular caliber. Four out of these five loci were confirmed in independent replication samples. In the combined analyses, the top SNPs at each locus were: rs2287921 (19q13; p = 1.61×10(-25), within the RASIP1 locus), rs225717 (6q24; p=1.25×10(-16), adjacent to the VTA1 and NMBR loci), rs10774625 (12q24; p = 2.15×10(-13), in the region of ATXN2,SH2B3 and PTPN11 loci), and rs17421627 (5q14; p=7.32×10(-16), adjacent to the MEF2C locus). In two independent samples, locus 12q24 was also associated with coronary heart disease and hypertension. Our population-based genome-wide association study demonstrates four novel loci associated with retinal venular caliber, an endophenotype of the microcirculation associated with clinical cardiovascular disease. These data provide further insights into the contribution and biological mechanisms of microcirculatory changes that underlie cardiovascular dis
AU  - Ikram,MK
AU  - Sim,X
AU  - Jensen,RA
AU  - Cotch,MF
AU  - Hewitt,AW
AU  - Ikram,MA
AU  - Wang,JJ
AU  - Klein,R
AU  - Klein,BE
AU  - Breteler,MM
AU  - Cheung,N
AU  - Liew,G
AU  - Mitchell,P
AU  - Uitterlinden,AG
AU  - Rivadeneira,F
AU  - Hofman,A
AU  - de,Jong PT
AU  - van,Duijn CM
AU  - Kao,L
AU  - Cheng,CY
AU  - Smith,AV
AU  - Glazer,NL
AU  - Lumley,T
AU  - McKnight,B
AU  - Psaty,BM
AU  - Jonasson,F
AU  - Eiriksdottir,G
AU  - Aspelund,T
AU  - Global,BPgen Consortium
AU  - Harris,TB
AU  - Launer,LJ
AU  - Taylor,KD
AU  - Li,X
AU  - Iyengar,SK
AU  - Xi,Q
AU  - Sivakumaran,TA
AU  - Mackey,DA
AU  - Macgregor,S
AU  - Martin,NG
AU  - Young,TL
AU  - Bis,JC
AU  - Wiggins,KL
AU  - Heckbert,SR
AU  - Hammond,CJ
AU  - Andrew,T
AU  - Fahy,S
AU  - Attia,J
AU  - Holliday,EG
AU  - Scott,RJ
AU  - Islam,FM
AU  - Rotter,JI
AU  - McAuley,AK
AU  - Boerwinkle,E
AU  - Tai,ES
AU  - Gudnason,V
AU  - Siscovick,DS
AU  - Vingerling,JR
AU  - Wong,TY
DO  - 10.1371/journal.pgen.1001184
PY  - 2010///
SN  - 1553-7390
TI  - Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo.
T2  - PLOS Genetics
UR  - http://dx.doi.org/10.1371/journal.pgen.1001184
UR  - http://hdl.handle.net/10044/1/28716
VL  - 6
ER  -
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