Imperial College London
Alternate

Dr Toby Andrew

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 0968t.andrew

 
 
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Location

 

ICTEM 526ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nettleton:2010:10.2337/dc10-1150,
author = {Nettleton, JA and McKeown, NM and Kanoni, S and Lemaitre, RN and Hivert, MF and Ngwa, J and van, Rooij FJ and Sonestedt, E and Wojczynski, MK and Ye, Z and Tanaka, T and Garcia, M and Anderson, JS and Follis, JL and Djousse, L and Mukamal, K and Papoutsakis, C and Mozaffarian, D and Zillikens, MC and Bandinelli, S and Bennett, AJ and Borecki, IB and Feitosa, MF and Ferrucci, L and Forouhi, NG and Groves, CJ and Hallmans, G and Harris, T and Hofman, A and Houston, DK and Hu, FB and Johansson, I and Kritchevsky, SB and Langenberg, C and Launer, L and Liu, Y and Loos, RJ and Nalls, M and Orho-Melander, M and Renstrom, F and Rice, K and Riserus, U and Rolandsson, O and Rotter, JI and Saylor, G and Sijbrands, EJ and Sjogren, P and Smith, A and Steingrímsdóttir, L and Uitterlinden, AG and Wareham, NJ and Prokopenko, I and Pankow, JS and van, Duijn CM and Florez, JC and Witteman, JC and MAGIC, Investigators and Dupuis, J and Dedoussis, GV and Ordovas, JM and Ingelsson, E and Cupples, L and Si},
doi = {10.2337/dc10-1150},
journal = {Diabetes Care},
pages = {2684--2691},
title = {Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies.},
url = {http://dx.doi.org/10.2337/dc10-1150},
volume = {33},
year = {2010}
}
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TY  - JOUR
AB  - OBJECTIVE: Whole-grain foods are touted for multiple health benefits, including enhancing insulin sensitivity and reducing type 2 diabetes risk. Recent genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) associated with fasting glucose and insulin concentrations in individuals free of diabetes. We tested the hypothesis that whole-grain food intake and genetic variation interact to influence concentrations of fasting glucose and insulin. RESEARCH DESIGN AND METHODS: Via meta-analysis of data from 14 cohorts comprising ∼ 48,000 participants of European descent, we studied interactions of whole-grain intake with loci previously associated in GWAS with fasting glucose (16 loci) and/or insulin (2 loci) concentrations. For tests of interaction, we considered a P value <0.0028 (0.05 of 18 tests) as statistically significant. RESULTS: Greater whole-grain food intake was associated with lower fasting glucose and insulin concentrations independent of demographics, other dietary and lifestyle factors, and BMI (β [95% CI] per 1-serving-greater whole-grain intake: -0.009 mmol/l glucose [-0.013 to -0.005], P < 0.0001 and -0.011 pmol/l [ln] insulin [-0.015 to -0.007], P = 0.0003). No interactions met our multiple testing-adjusted statistical significance threshold. The strongest SNP interaction with whole-grain intake was rs780094 (GCKR) for fasting insulin (P = 0.006), where greater whole-grain intake was associated with a smaller reduction in fasting insulin concentrations in those with the insulin-raising allele. CONCLUSIONS: Our results support the favorable association of whole-grain intake with fasting glucose and insulin and suggest a potential interaction between variation in GCKR and whole-grain intake in influencing fasting insulin concentrations.
AU  - Nettleton,JA
AU  - McKeown,NM
AU  - Kanoni,S
AU  - Lemaitre,RN
AU  - Hivert,MF
AU  - Ngwa,J
AU  - van,Rooij FJ
AU  - Sonestedt,E
AU  - Wojczynski,MK
AU  - Ye,Z
AU  - Tanaka,T
AU  - Garcia,M
AU  - Anderson,JS
AU  - Follis,JL
AU  - Djousse,L
AU  - Mukamal,K
AU  - Papoutsakis,C
AU  - Mozaffarian,D
AU  - Zillikens,MC
AU  - Bandinelli,S
AU  - Bennett,AJ
AU  - Borecki,IB
AU  - Feitosa,MF
AU  - Ferrucci,L
AU  - Forouhi,NG
AU  - Groves,CJ
AU  - Hallmans,G
AU  - Harris,T
AU  - Hofman,A
AU  - Houston,DK
AU  - Hu,FB
AU  - Johansson,I
AU  - Kritchevsky,SB
AU  - Langenberg,C
AU  - Launer,L
AU  - Liu,Y
AU  - Loos,RJ
AU  - Nalls,M
AU  - Orho-Melander,M
AU  - Renstrom,F
AU  - Rice,K
AU  - Riserus,U
AU  - Rolandsson,O
AU  - Rotter,JI
AU  - Saylor,G
AU  - Sijbrands,EJ
AU  - Sjogren,P
AU  - Smith,A
AU  - Steingrímsdóttir,L
AU  - Uitterlinden,AG
AU  - Wareham,NJ
AU  - Prokopenko,I
AU  - Pankow,JS
AU  - van,Duijn CM
AU  - Florez,JC
AU  - Witteman,JC
AU  - MAGIC,Investigators
AU  - Dupuis,J
AU  - Dedoussis,GV
AU  - Ordovas,JM
AU  - Ingelsson,E
AU  - Cupples,L
AU  - Siscovick,DS
AU  - Franks,PW
AU  - Meigs,JB
DO  - 10.2337/dc10-1150
EP  - 2691
PY  - 2010///
SN  - 0149-5992
SP  - 2684
TI  - Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies.
T2  - Diabetes Care
UR  - http://dx.doi.org/10.2337/dc10-1150
UR  - http://hdl.handle.net/10044/1/28752
VL  - 33
ER  -
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