Imperial College London
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Professor Thanos Athanasiou MD PhD MBA FECTS FRCS

Faculty of Medicine, Department of Surgery & Cancer

Professor of Cardiovascular Sciences
 
 
 
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Contact

 

t.athanasiou

 
 
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Location

 

1022Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Salmasi:2020:10.1111/jocs.14712,
author = {Salmasi, MY and Panda, A and Hartley, P and Abdulkhader, A and Osman, A and Nienaber, C and Athanasiou, T and Asimakopoulos, G},
doi = {10.1111/jocs.14712},
journal = {Journal of Cardiac Surgery},
pages = {1840--1847},
title = {Aortic root replacement to treat type A aortic dissection: A comparison of midterm outcomes between composite valve grafts and porcine aortic roots.},
url = {http://dx.doi.org/10.1111/jocs.14712},
volume = {35},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Porcine aortic roots (PAR) have been reported in the literature with acceptable short- and long-term outcomes for the treatment of aortic root aneurysms. However, their efficacy in type A aortic dissection (TAAD) is yet to be defined. METHODS: Using data from a locally collated aortic dissection registry, we compared the outcomes in patients undergoing aortic root replacement for TAAD using either of two surgical options: (a) PAR or (b) composite valve grafts (CVG). A retrospective analysis was conducted for all procedures in the period from 2005 to 2018. RESULTS: A total of 252 patients underwent procedures for TAAD in the time period. Sixty-five patients had aortic root replacements (PAR n = 30, CVG n = 35). Between-group comparisons identified a younger CVG group (50.5 vs 64.5, P < .05) although all other covariates were comparable. Operative parameters were comparable between the two groups. The use of PAR did not significantly impact operative mortality (odds ratio [OR], 0.93; 95% confidence interval [CI], 0.22-3.61; P = .992), stroke (OR, 2.91, 0.25-34.09, P = .395), reoperation (OR, 0.91; 95% CI, 0.22-3.62; P = .882) or length of stay (coeff 2.33, -8.23 to 12.90; P = .659) compared to CVG. Five-year survival was similar between both groups (PAR 59% vs CVG 69%; P = .153) and reoperation was negligible. Echocardiography revealed significantly lower aortic valve gradients in the PAR group (8.69 vs 15.45mm Hg; P < .0001), and smaller left ventricular dimensions both at 6-week and 1-year follow-up (P < .05). CONCLUSIONS: This study highlights the comparable short- and midterm outcomes of PAR in cases of TAAD, in comparison to established therapy.
AU  - Salmasi,MY
AU  - Panda,A
AU  - Hartley,P
AU  - Abdulkhader,A
AU  - Osman,A
AU  - Nienaber,C
AU  - Athanasiou,T
AU  - Asimakopoulos,G
DO  - 10.1111/jocs.14712
EP  - 1847
PY  - 2020///
SN  - 0886-0440
SP  - 1840
TI  - Aortic root replacement to treat type A aortic dissection: A comparison of midterm outcomes between composite valve grafts and porcine aortic roots.
T2  - Journal of Cardiac Surgery
UR  - http://dx.doi.org/10.1111/jocs.14712
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32643831
UR  - https://onlinelibrary.wiley.com/doi/full/10.1111/jocs.14712
UR  - http://hdl.handle.net/10044/1/80640
VL  - 35
ER  -
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