Imperial College London
Alternate

ProfessorTimBarraclough

Faculty of Natural Sciences, Department of Life Sciences (Silwood Park)

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 2247t.barraclough Website

 
 
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Location

 

N2.4Silwood ParkSilwood Park

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Summary

 

Publications

Citation

BibTex format

@article{Johnson:2015:10.3390/nu7064480,
author = {Johnson, LP and Walton, GE and Psichas, A and Frost, GS and Gibson, GR and Barraclough, TG},
doi = {10.3390/nu7064480},
journal = {Nutrients},
pages = {4480--4497},
title = {Prebiotics modulate the effects of antibiotics on gut microbial diversity and functioning in vitro},
url = {http://dx.doi.org/10.3390/nu7064480},
volume = {7},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Intestinal bacteria carry out many fundamental roles, such as the fermentation of non-digestible dietary carbohydrates to produce short chain fatty acids (SCFAs), which can affect host energy levels and gut hormone regulation. Understanding how to manage this ecosystem to improve human health is an important but challenging goal. Antibiotics are the front line of defence against pathogens, but in turn they have adverse effects on indigenous microbial diversity and function. Here, we have investigated whether dietary supplementation—another method used to modulate gut composition and function—could be used to ameliorate the side effects of antibiotics. We perturbed gut bacterial communities with gentamicin and ampicillin in anaerobic batch cultures in vitro. Cultures were supplemented with either pectin (a non-fermentable fibre), inulin (a commonly used prebiotic that promotes the growth of beneficial bacteria) or neither. Although antibiotics often negated the beneficial effects of dietary supplementation, in some treatment combinations, notably ampicillin and inulin, dietary supplementation ameliorated the effects of antibiotics. There is therefore potential for using supplements to lessen the adverse effects of antibiotics. Further knowledge of such mechanisms could lead to better therapeutic manipulation of the human gut microbiota.
AU  - Johnson,LP
AU  - Walton,GE
AU  - Psichas,A
AU  - Frost,GS
AU  - Gibson,GR
AU  - Barraclough,TG
DO  - 10.3390/nu7064480
EP  - 4497
PY  - 2015///
SN  - 2072-6643
SP  - 4480
TI  - Prebiotics modulate the effects of antibiotics on gut microbial diversity and functioning in vitro
T2  - Nutrients
UR  - http://dx.doi.org/10.3390/nu7064480
UR  - http://hdl.handle.net/10044/1/32364
VL  - 7
ER  -
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