Publications
552 results found
Al-Memar M, Bobdiwala S, Madhra M, et al., 2016, The potential value of activin B and fibronectin as biomarkers to predict outcome in pregnancies of unknown location and first trimester viability, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 123, Pages: 241-241, ISSN: 1470-0328
Bobdiwala S, Farren J, Mitchell-Jones N, et al., 2016, Managing pregnancy of unknown location based on initial serum progesterone and serial serum hCG: A multi-centre trial on the performance and complications associated with using a two-step triage protocol, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 123, Pages: 76-77, ISSN: 1470-0328
Sundar S, Rick C, Dowling F, et al., 2016, Refining Ovarian Cancer Test accuracy Scores (ROCkeTS) trial update, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 123, Pages: 102-102, ISSN: 1470-0328
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- Citations: 1
Al-Memar M, Saso S, Bobdiwala S, et al., 2016, Validation of a virtual reality simulator for the use of transvaginal ultrasound in gynaecology and early pregnancy, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 123, Pages: 212-212, ISSN: 1470-0328
Froyman W, Landolfo C, Bourne T, et al., 2016, Performance of the RMI and IOTA ADNEX and Simple Rules risk model in the evaluation of adnexal masses not classifiable using the Easy Descriptors as first step, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 123, Pages: 83-84, ISSN: 1470-0328
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- Citations: 1
Mitchell-Jones N, Gallos I, Farren J, et al., 2016, Psychological morbidity associated with hyperemesis gravidarum; a systematic review and meta-analysis, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 123, Pages: 39-39, ISSN: 1470-0328
Farren J, Bobdiwala S, Mitchell-Jones N, et al., 2016, The role of bleeding score in the prediction of outcome in pregnancies of unknown location: a multicentre study, Publisher: WILEY-BLACKWELL, Pages: 77-77, ISSN: 1470-0328
Bobdiwala S, Guha S, Van Calster B, et al., 2016, The clinical performance of the M4 decision support model to triage women with a pregnancy of unknown location as at low or high risk of complications, Human Reproduction, Vol: 31, Pages: 1425-1435, ISSN: 0268-1161
Study question: What are the adverse outcomes associated with using the M4 model in everyday clinical practice for women with pregnancyof unknown location (PUL)?Summary answer: There were 17/835 (2.0%) adverse events and no serious adverse events associated with the performance of the M4model in clinical practice.What is known already: The M4 model has previously been shown to stratify women classified as a PUL as at low or high risk ofcomplications with a good level of test performance. The triage performance of the M4 model is better than single measurements of serum progesteroneor the hCG ratio (serum hCG at 48 h/hCG at presentation).Study design, size, duration: A prospective multi-centre cohort study of 1022 women with a PUL carried out between August2012 and December 2013 across 2 university teaching hospitals and 1 district general hospital.Participants/materials, setting, methods: All women presenting with a PUL to the early pregnancy units of the three hospitalswere recruited. The final outcome for PUL was either a failed PUL (FPUL), intrauterine pregnancy (IUP) or ectopic pregnancy (EP) (includingpersistent PUL (PPUL)), with EP and PPUL considered high-risk PUL. Their hCG results at 0 and 48 h were entered into the M4 model algorithm.If the risk of EP was ≥5%, the PUL was predicted to be high-risk and the participant was asked to re-attend 48 h later for a repeat hCG and transvaginalultrasound scan by a senior clinician. If the PUL was classified as ‘low risk, likely failed PUL’, the participant was asked to perform a urinary pregnancy test2 weeks later. If the PUL was classified as ‘low risk, likely intrauterine’, the participant was scheduled for a repeat scan in 1 week. Deviations from themanagement protocol were recorded as either an ‘unscheduled visit (participant reason)’, ‘unscheduled visit (clinician reason)’ or ‘differencesin timing(blood test/ultrasound)’. Adverse events were assessed
Bourne T, 2016, Cutting GMC investigations must not simply devolve problems elsewhere, British Medical Journal, Vol: 353, ISSN: 1468-5833
Van Schoubroeck D, Raine-Fenning N, Installé AJ, et al., 2016, Interobserver agreement in assessment of polycystic ovarian morphology using pattern recognition, Ultrasound in Obstetrics & Gynecology, Vol: 47, Pages: 652-653, ISSN: 1469-0705
Timmerman D, Van Calster B, Testa A, et al., 2016, Predicting the risk of malignancy in adnexal masses based on the Simple Rules from the International Ovarian Tumor Analysis group, American Journal of Obstetrics and Gynecology, Vol: 214, Pages: 424-437, ISSN: 1097-6868
BACKGROUND: Accurate methods to preoperatively characterize adnexal tumors are pivotal for optimal patient management. A recent metaanalysis concluded that the International Ovarian Tumor Analysis algorithms such as the Simple Rules are the best approaches to preoperatively classify adnexal masses as benign or malignant. OBJECTIVE: We sought to develop and validate a model to predict the risk of malignancy in adnexal masses using the ultrasound features in the Simple Rules. STUDY DESIGN: This was an international cross-sectional cohort study involving 22 oncology centers, referral centers for ultrasonography, and general hospitals. We included consecutive patients with an adnexal tumor who underwent a standardized transvaginal ultrasound examination and were selected for surgery. Data on 5020 patients were recorded in 3 phases from 2002 through 2012. The 5 Simple Rules features indicative of a benign tumor (B-features) and the 5 features indicative of malignancy (M-features) are based on the presence of ascites, tumor morphology, and degree of vascularity at ultrasonography. Gold standard was the histopathologic diagnosis of the adnexal mass (pathologist blinded to ultrasound findings). Logistic regression analysis was used to estimate the risk of malignancy based on the 10 ultrasound features and type of center. The diagnostic performance was evaluated by area under the receiver operating characteristic curve, sensitivity, specificity, positive likelihood ratio (LR+), negative likelihood ratio (LR-), positive predictive value (PPV), negative predictive value (NPV), and calibration curves. RESULTS: Data on 4848 patients were analyzed. The malignancy rate was 43% (1402/3263) in oncology centers and 17% (263/1585) in other centers. The area under the receiver operating characteristic curve on validation data was very similar in oncology centers (0.917; 95% confidence interval, 0.901-0.931) and other centers (0.916; 95% confidence interval, 0.873-0.945). Risk estimates
Froyman W, Landolfo C, Amant F, et al., 2016, Morcellation and risk of malignancy in presumed ovarian fibromas/fibrothecomas, Lancet Oncology, Vol: 17, Pages: 273-274, ISSN: 1474-5488
Bourne T, 2016, Why greater emphasis must be given to getting the diagnosis right: the example of miscarriage., Australas J Ultrasound Med, Vol: 19, Pages: 3-5, ISSN: 1836-6864
Ibrahim DA, Al-Assam H, Du H, et al., 2016, Automatic Segmentation and Measurements of Gestational Sac Using Static B-Mode Ultrasound Images, Conference on Mobile Multimedia/Image Processing, Security, and Applications, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X
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- Citations: 2
Kaijser J, Bourne T, De Rijdt S, et al., 2015, Key findings from the International Ovarian Tumor Analysis (IOTA) study: an approach to the optimal ultrasound based characterisation of adnexal pathology, Australian Journal of Ultrasound in Medicine, Vol: 15, Pages: 82-86, ISSN: 2205-0140
The principal aim of the IOTA project has been to develop approaches to the evaluation of adnexal pathology using ultrasound that can be transferred to all examiners. Creating models that use simple, easily reproducible ultrasound characteristics is one approach.
Bobdiwala S, Guha S, Al-Memar M, et al., 2015, The clinical performance of the M4 decision support model to triage women with a pregnancy of unknown location as at low or high risk of complications, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 122, Pages: 12-12, ISSN: 1470-0328
Bobdiwala S, Al-Memar M, Van Calster B, et al., 2015, Using a two-stage strategy: serum progesterone at presentation and a novel risk model based on progesterone and serial serum hCG to manage pregnancy of unknown location (PUL), BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 122, Pages: 11-12, ISSN: 1470-0328
Bourne T, Preisler J, Van Calster B, et al., 2015, DIAGNOSING MISCARRIAGE Additional factors to take into account when diagnosing miscarriage Reply, BMJ-BRITISH MEDICAL JOURNAL, Vol: 351, ISSN: 0959-535X
Bobdiwala S, Al-Memar M, van Calster B, et al., 2015, Managing pregnancy of unknown location (PUL): a two-step approach using initial serum progesterone and a novel risk prediction model based on serial serum hCG levels, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 122, Pages: E13-E13, ISSN: 1470-0328
Preisler J, Kopeika J, Ismail L, et al., 2015, Defining safe criteria to diagnose miscarriage: prospective observational multicentre study, BMJ: British Medical Journal, Vol: 351, Pages: 1-10, ISSN: 0959-535X
Objectives To validate recent guidance changes by establishing the performance of cut-off values for embryo crown-rump length and mean gestational sac diameter to diagnose miscarriage with high levels of certainty. Secondary aims were to examine the influence of gestational age on interpretation of mean gestational sac diameter and crown-rump length values, determine the optimal intervals between scans and findings on repeat scans that definitively diagnose pregnancy failure.)Design Prospective multicentre observational trial.Setting Seven hospital based early pregnancy assessment units in the United Kingdom.Participants 2845 women with intrauterine pregnancies of unknown viability included if transvaginal ultrasonography showed an intrauterine pregnancy of uncertain viability. In three hospitals this was initially defined as an empty gestational sac <20 mm mean diameter with or without a visible yolk sac but no embryo, or an embryo with crown-rump length <6 mm with no heartbeat. Following amended guidance in December 2011 this definition changed to a gestational sac size <25 mm or embryo crown-rump length <7 mm. At one unit the definition was extended throughout to include a mean gestational sac diameter <30 mm or embryo crown-rump length <8 mm.Main outcome measures Mean gestational sac diameter, crown-rump length, and presence or absence of embryo heart activity at initial and repeat transvaginal ultrasonography around 7-14 days later. The final outcome was pregnancy viability at 11-14 weeks’ gestation.Results The following indicated a miscarriage at initial scan: mean gestational sac diameter ≥25 mm with an empty sac (364/364 specificity: 100%, 95% confidence interval 99.0% to 100%), embryo with crown-rump length ≥7 mm without visible embryo heart activity (110/110 specificity: 100%, 96.7% to 100%), mean gestational sac diameter ≥18 mm for gestational sacs without an embryo presenting after 70 days’ gestation (907/907 specif
van den Bosch T, Dueholm M, Leone FPG, et al., 2015, Terms, definitions and measurements to describe sonographic features of myometrium and uterine masses: a consensus opinion from the Morphological Uterus Sonographic Assessment (MUSA) group, ULTRASOUND IN OBSTETRICS & GYNECOLOGY, Vol: 46, Pages: 284-298, ISSN: 0960-7692
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- Citations: 331
Kirk E, Bottomley C, Bourne T, 2015, Reply: Diagnostic and management modalities in early tubal pregnancy with focus on safety, HUMAN REPRODUCTION UPDATE, Vol: 21, Pages: 693-693, ISSN: 1355-4786
Kaijser J, Van Hoorde K, Van Calster B, et al., 2015, Diagnosing adnexal tumours before surgery: a critical appraisal of recent evidence, OBSTETRICIAN & GYNAECOLOGIST, Vol: 17, Pages: 163-171, ISSN: 1467-2561
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- Citations: 1
Al-Memar M, Kirk E, Bourne T, 2015, The role of ultrasonography in the diagnosis and management of early pregnancy complications, OBSTETRICIAN & GYNAECOLOGIST, Vol: 17, Pages: 173-181, ISSN: 1467-2561
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- Citations: 5
Sayasneh A, Kaijser J, Preisler J, et al., 2015, Accuracy of ultrasonography performed by examiners with varied training and experience in predicting specific pathology of adnexal masses, ULTRASOUND IN OBSTETRICS & GYNECOLOGY, Vol: 45, Pages: 605-612, ISSN: 0960-7692
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- Citations: 23
Van Hoorde K, Van Huffel S, Timmerman D, et al., 2015, A spline-based tool to assess and visualize the calibration of multiclass risk predictions, JOURNAL OF BIOMEDICAL INFORMATICS, Vol: 54, Pages: 283-293, ISSN: 1532-0464
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- Citations: 43
Bourne T, Bennett P, Bobdiwala S, et al., 2015, Surgeon acquittal in female genital mutilation case: Dharmasena case illustrates what is wrong with complaints procedures, BMJ, Vol: 350, ISSN: 1756-1833
Van den Bosch T, Ameye L, Van Schoubroeck D, et al., 2015, Intra-cavitary uterine pathology in women with abnormal uterine bleeding: a prospective study of 1220 women., Facts, Views and Vision in ObGyn, Vol: 7, Pages: 17-24, ISSN: 2032-0418
OBJECTIVES: Our primary aim was to assess how patients' characteristics, bleeding pattern, sonographic endometrial thickness (ET) and additional features at unenhanced ultrasound examination (UTVS) and at fluid instillation sonography (FIS) contribute to the diagnosis of intracavitary uterine pathology in women presenting with abnormal uterine bleeding (AUB). We further aimed to report the prevalence of pathology in women presenting with AUB. METHODS: 1220 consecutive women presenting with AUB underwent UTVS, colour Doppler imaging (CDI) and FIS. Most women (n = 1042) had histological diagnosis. RESULTS: Mean age was 50 years and 37% were postmenopausal. Of 1220 women 54% were normal, polyps were diagnosed in 26%, intracavitary fibroids in 11%, hyperplasia without atypia in 4% and cancer in 3%. All cancers were diagnosed in postmenopausal (7%) or perimenopausal (1%) women. ET had a low predictive value in premenopausal women (LR+ and LR- of 1.34 and 0.74, respectively), while FIS had a LR+ and LR- of 6.20 and 0.24, respectively. After menopause, ET outperformed all patient characteristics for the prediction of endometrial pathology (LR+ and LR- of 3.13 and 0.24). The corresponding LR+ and LR- were 10.85 and 0.71 for CDI and 8.23 and 0.26 for FIS. CONCLUSION: About half of the women presenting to a bleeding clinic will have pathology. In premenopausal women, benign lesions are often the cause of AUB. For the prediction of intracavitary pathology ET is of little value in premenopausal women. CDI and FIS substantially improve the diagnostic accuracy.
Sayasneh A, Ekechi C, Ferrara L, et al., 2015, The characteristic ultrasound features of specific types of ovarian pathology, INTERNATIONAL JOURNAL OF ONCOLOGY, Vol: 46, Pages: 445-458, ISSN: 1019-6439
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- Citations: 46
Van Calster B, Van Hoorde K, Froyman W, et al., 2015, Practical guidance for applying the ADNEX model from the IOTA group to discriminate between different subtypes of adnexal tumors, FACTS VIEWS AND VISION IN OBGYN, Vol: 7, Pages: 32-41, ISSN: 2032-0418
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- Citations: 59
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