Imperial College London
Alternate

Professor Tom Bourne

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Chair in Gynaecology
 
 
 
//

Contact

 

+44 (0)20 3313 5131t.bourne Website

 
 
//

Location

 

Early pregnancy and acute gynaecologyInstitute of Reproductive and Developmental BiologyHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Al-Memar:2020:10.1111/1471-0528.15972,
author = {Al-Memar, M and Bobdiwala, S and Fourie, H and Manino, R and Lee, YS and Smith, A and Marchesi, JR and Timmerman, D and Bourne, T and Bennett, PR and MacIntyre, DA},
doi = {10.1111/1471-0528.15972},
journal = {BJOG: an International Journal of Obstetrics and Gynaecology},
pages = {264--274},
title = {The association between vaginal bacterial composition and miscarriage: a nested case-control study},
url = {http://dx.doi.org/10.1111/1471-0528.15972},
volume = {127},
year = {2020}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE: To characterise vaginal bacterial composition in early pregnancy and investigate its relationship with first and second trimester miscarriages. DESIGN: Nested case-control study. SETTING: Queen Charlotte's and Chelsea Hospital, Imperial College Healthcare NHS Trust, London. POPULATION: 161 pregnancies; 64 resulting in first trimester miscarriage, 14 in second trimester miscarriage and 83 term pregnancies. METHODS: Prospective profiling and comparison of vaginal bacteria composition using 16S rRNA gene-based metataxonomics from 5 weeks gestation in pregnancies ending in miscarriage or uncomplicated term deliveries matched for age, gestation and body-mass index. MAIN OUTCOME MEASURES: Relative vaginal bacteria abundance, diversity and richness. Pregnancy outcomes defined as first or second trimester miscarriage, or uncomplicated term delivery. RESULTS: First trimester miscarriage associated with reduced prevalence of Lactobacillus spp.-dominated vaginal microbiota classified using hierarchical clustering analysis (65.6% vs. 87·7%; P=0·005), higher alpha diversity (mean Inverse Simpson Index 2.5 (95% confidence interval 1.8-3.0) vs. 1.5 (1.3-1.7), P=0·003) and higher richness 25.1 (18.5-31.7) vs. 16.7 (13.4-20), P=0·017), compared to viable pregnancies. This was independent of vaginal bleeding and observable before first trimester miscarriage diagnosis (P=0·015). Incomplete/complete miscarriage associated with higher proportions of Lactobacillus spp.-deplete communities compared to missed miscarriage. Early pregnancy vaginal bacterial stability was similar between miscarriage and term pregnancies. CONCLUSIONS: These findings associate the bacterial component of vaginal microbiota with first trimester miscarriage and indicate suboptimal community composition is established in early pregnancy. While further studies are required to elucidate the mechanism, vaginal bacterial composition may represent a modifiable risk factor fo
AU  - Al-Memar,M
AU  - Bobdiwala,S
AU  - Fourie,H
AU  - Manino,R
AU  - Lee,YS
AU  - Smith,A
AU  - Marchesi,JR
AU  - Timmerman,D
AU  - Bourne,T
AU  - Bennett,PR
AU  - MacIntyre,DA
DO  - 10.1111/1471-0528.15972
EP  - 274
PY  - 2020///
SN  - 1470-0328
SP  - 264
TI  - The association between vaginal bacterial composition and miscarriage: a nested case-control study
T2  - BJOG: an International Journal of Obstetrics and Gynaecology
UR  - http://dx.doi.org/10.1111/1471-0528.15972
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31573753
UR  - https://obgyn.onlinelibrary.wiley.com/doi/full/10.1111/1471-0528.15972
UR  - http://hdl.handle.net/10044/1/73792
VL  - 127
ER  -
Download