Imperial College London
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Dr. Tobias Buchborn, Dipl. Psych.

Faculty of Medicine, Department of Brain Sciences

Honorary Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 3205t.buchborn

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{Buchborn:2016,
author = {Buchborn, T and Grecksch, G and Dieterich, D and Hoellt, V},
booktitle = {Neuropathology of Drug Addictions and Substance Misuse. Volume 2: Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects.},
editor = {Preedy},
pages = {846--858},
title = {Tolerance to Lysergic Acid Diethylamide: Overview, Correlates, and Clinical Implication},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - CHAP
AB  - The first reports on tolerance to the serotonergic hallucinogen lysergic acid diethylamide (LSD) were published half a century ago, yet hitherto, a systematic review on this topic is not available. In this chapter, we discuss tolerance to LSD with regard to its psychedelic and somatic effects in humans, as well as selected behaviors in animals. In humans, mental tolerance to LSD substantially manifests 24 h after its first administration and reaches a maximum by around the fourth day. Once established, tolerance cannot be overcome even if the initial dose is quadrupled. Mental tolerance to LSD generalizes to psilocybin and mescaline but not to tetrahydrocannabinol or amphetamine. As to LSD’s somatic effects, mental tolerance most reliably is accompanied by tolerance to mydriasis. Five days of abstinence is sufficient for tolerance to be reversed; symptoms of withdrawal are not encountered. In animals, LSD-induced shaking behavior, limb flicking, and hallucinogenic pausing are undermined by tolerance, too; the first-mentioned behaviors, for instance, are subject to tachyphylaxis. Mechanistically, pharmacodynamic adaptations of serotonin 5-HT2A and/or (downstream) glutamate receptors are likely to account for tolerance; a learning-related precipitation, however, has also been described. The rapid onset of mental tolerance probably is a main reason LSD generally is not taken on an everyday basis by humans. Given its rapid reversal, on the other hand, a once-per-week abuse cannot be excluded.
AU  - Buchborn,T
AU  - Grecksch,G
AU  - Dieterich,D
AU  - Hoellt,V
EP  - 858
PY  - 2016///
SP  - 846
TI  - Tolerance to Lysergic Acid Diethylamide: Overview, Correlates, and Clinical Implication
T1  - Neuropathology of Drug Addictions and Substance Misuse. Volume 2: Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects.
ER  -
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