Imperial College London

Professor Tony Cass

Faculty of Natural SciencesDepartment of Chemistry

Professor of Chemistry



+44 (0)20 7594 5195t.cass




301KMolecular Sciences Research HubWhite City Campus






BibTex format

author = {Sharma, S and Huang, Z and Rogers, M and Boutelle, M and Cass, AEG},
doi = {10.1007/s00216-016-9961-6},
journal = {Analytical and Bioanalytical Chemistry},
pages = {8427--8435},
title = {Evaluation of a minimally invasive glucose biosensor for continuous tissue monitoring},
url = {},
volume = {408},
year = {2016}

RIS format (EndNote, RefMan)

AB - We describe here a minimally invasive glucose biosensor based on a microneedle array electrode fabricated from an epoxy-based negative photoresist (SU8 50) and designed for continuous measurement in the dermal compartment with minimal pain. These minimally invasive, continuous monitoring sensor devices (MICoMS) were produced by casting the structures in SU8 50, crosslinking and then metallising them with platinum or silver to obtain the working and reference electrodes, respectively. The metallised microneedle array electrodes were subsequently functionalised by entrapping glucose oxidase in electropolymerised polyphenol (PP) film. Sensor performance in vitro showed that glucose concentrations down to 0.5 mM could be measured with a response times (T90) of 15 s. The effect of sterilisation by Co60 irradiation was evaluated. In preparation for further clinical studies, these sensors were tested in vivo in a healthy volunteer for a period of 3–6 h. The sensor currents were compared against point measurements obtained with a commercial capillary blood glucometer. The epoxy MICoMS devices showed currents values that could be correlated with these.
AU - Sharma,S
AU - Huang,Z
AU - Rogers,M
AU - Boutelle,M
AU - Cass,AEG
DO - 10.1007/s00216-016-9961-6
EP - 8435
PY - 2016///
SN - 1618-2650
SP - 8427
TI - Evaluation of a minimally invasive glucose biosensor for continuous tissue monitoring
T2 - Analytical and Bioanalytical Chemistry
UR -
UR -
VL - 408
ER -