Imperial College London

Professor Tony Cass

Faculty of Natural SciencesDepartment of Chemistry

Professor of Chemistry



+44 (0)20 7594 5195t.cass




301KMolecular Sciences Research HubWhite City Campus






BibTex format

author = {Rawson, T and o'hare, D and Herrero, P and Sharma, S and Moore, L and de, Barra E and Roberts, J and Gordon, A and Hope, W and Georgiou, P and Cass, A and Holmes, A},
doi = {jac/dkx458},
journal = {Journal of Antimicrobial Chemotherapy},
pages = {835--843},
title = {Delivering precision antimicrobial therapy through closed-loop control systems},
url = {},
volume = {73},
year = {2018}

RIS format (EndNote, RefMan)

AB - Sub-optimal exposure to antimicrobial therapy is associated with poor patient outcomes and the development of antimicrobial resistance. Mechanisms for optimizing the concentration of a drug within the individual patient are under development. However, several barriers remain in realizing true individualization of therapy. These include problems with plasma drug sampling, availability of appropriate assays, and current mechanisms for dose adjustment. Biosensor technology offers a means of providing real-time monitoring of antimicrobials in a minimally invasive fashion. We report the potential for using microneedle biosensor technology as part of closed-loop control systems for the optimization of antimicrobial therapy in individual patients.
AU - Rawson,T
AU - o'hare,D
AU - Herrero,P
AU - Sharma,S
AU - Moore,L
AU - de,Barra E
AU - Roberts,J
AU - Gordon,A
AU - Hope,W
AU - Georgiou,P
AU - Cass,A
AU - Holmes,A
DO - jac/dkx458
EP - 843
PY - 2018///
SN - 0305-7453
SP - 835
TI - Delivering precision antimicrobial therapy through closed-loop control systems
T2 - Journal of Antimicrobial Chemotherapy
UR -
UR -
VL - 73
ER -