Imperial College London

Professor Tony Cass

Faculty of Natural SciencesDepartment of Chemistry

Professor of Chemistry
 
 
 
//

Contact

 

+44 (0)20 7594 5195t.cass

 
 
//

Location

 

6.23Flowers buildingSouth Kensington Campus

//

Summary

 

Publications

Publication Type
Year
to

189 results found

Elson DS, Singh M, Nabavi E, Zhou Y, Zhao H, Ma D, Cass A, Hanna Get al., Application of Gold Nanorods in Cancer Theranostics, Association of Surgeons in Training

CONFERENCE PAPER

Harris-Birtill D, Singh M, Zhou YU, Shah A, Gallina M, Cass A, Bamber J, Hanna G, Elson DSet al., Gold Nanorod Reshaping using a Continuous Wave Laser, Bio-Nano-Photonics Symposium

CONFERENCE PAPER

Nabavi E, Singh M, Zhou Y, Gallina M, Zhao H, Ma D, Cass A, Hanna G, Elson DSet al., Preliminary studies of targeted NIR photothermal therapy of human oesophageal adenocarcinoma in mice using multifunctional GNRs, British Medical Laser Association Conference

CONFERENCE PAPER

Singh M, Nabavi E, Zhou Y, Gallina M, Zhao H, Ma D, Cass A, Hanna G, Elson DSet al., Application of Gold Nanoparticles for Photothermal Therapy of Upper Gastrointestinal Adenocarcinoma, Bio-Nano-Photonics Symposium

CONFERENCE PAPER

Singh M, Nabavi E, Zhou Y, Zhao H, Ma D, Cass A, Hanna G, Elson DSet al., Application of Gold Nanorods in Cancer Theranostics (plenary presentation winner), Society for Surgery of the Alimentary Tract Annual Meeting, 31st Annual SSAT Residents and Fellows Research Conference

CONFERENCE PAPER

Cass AE, Sharma S, 2017, Microneedle Enzyme Sensor Arrays for Continuous In Vivo Monitoring., Methods Enzymol, Vol: 589, Pages: 413-427

Microneedle enzyme sensors by virtue of their minimally invasive and hence pain-free penetration of skin allow for the measurement of metabolites, biomarkers, and drugs in the interstitial fluid that bathes the dermal tissue. Such devices if they are to be adopted widely into clinical practice need to be capable of delivering reliable measurements over extended periods of time (days) and to be fabricated by low-cost, scalable methods. Using injection molding of the base structures in polycarbonate, metal film deposition by sputtering and enzyme immobilization by electrodeposition can meet these requirements. The workflow to produce devices for clinical evaluation is then completed by sterilization and packaging. In vitro evaluation of the sensors' response to varying analyte concentrations and their mechanical testing establish performance and safety characteristics. While most of the work is focused on glucose sensing, reflecting the significance of the global diabetes "epidemic," the microneedles can also be used to measure lactate (another metabolite) and theophylline (a therapeutic drug).

JOURNAL ARTICLE

Le TT, Chang P, Benton DJ, McCauley JW, Iqbal M, Cass AEGet al., 2017, Dual Recognition Element Lateral Flow Assay Toward Multiplex Strain Specific Influenza Virus Detection, ANALYTICAL CHEMISTRY, Vol: 89, Pages: 6781-6786, ISSN: 0003-2700

JOURNAL ARTICLE

Sharma S, Cass AEG, 2017, Microneedle Enzyme Sensor Arrays for Continuous In Vivo Monitoring, Methods in Enzymology, Pages: 414-426

Microneedle enzyme sensors by virtue of their minimally invasive and hence pain-free penetration of skin allow for the measurement of metabolites, biomarkers, and drugs in the interstitial fluid that bathes the dermal tissue. Such devices if they are to be adopted widely into clinical practice need to be capable of delivering reliable measurements over extended periods of time (days) and to be fabricated by low-cost, scalable methods. Using injection molding of the base structures in polycarbonate, metal film deposition by sputtering and enzyme immobilization by electrodeposition can meet these requirements. The workflow to produce devices for clinical evaluation is then completed by sterilization and packaging. In vitro evaluation of the sensors' response to varying analyte concentrations and their mechanical testing establish performance and safety characteristics. While most of the work is focused on glucose sensing, reflecting the significance of the global diabetes "epidemic," the microneedles can also be used to measure lactate (another metabolite) and theophylline (a therapeutic drug).

BOOK CHAPTER

Sharma S, Saeed A, Johnson C, Gadegaard N, Cass AEet al., 2017, Rapid, low cost prototyping of transdermal devices for personal healthcare monitoring., Sens Biosensing Res, Vol: 13, Pages: 104-108, ISSN: 2214-1804

The next generation of devices for personal healthcare monitoring will comprise molecular sensors to monitor analytes of interest in the skin compartment. Transdermal devices based on microneedles offer an excellent opportunity to explore the dynamics of molecular markers in the interstitial fluid, however good acceptability of these next generation devices will require several technical problems associated with current commercially available wearable sensors to be overcome. These particularly include reliability, comfort and cost. An essential pre-requisite for transdermal molecular sensing devices is that they can be fabricated using scalable technologies which are cost effective. We present here a minimally invasive microneedle array as a continuous monitoring platform technology. Method for scalable fabrication of these structures is presented. The microneedle arrays were characterised mechanically and were shown to penetrate human skin under moderate thumb pressure. They were then functionalised and evaluated as glucose, lactate and theophylline biosensors. The results suggest that this technology can be employed in the measurement of metabolites, therapeutic drugs and biomarkers and could have an important role to play in the management of chronic diseases.

JOURNAL ARTICLE

Gallina ME, Zhou Y, Johnson CJ, Harris-Birtill D, Singh M, Zhao H, Ma D, Cass T, Elson DSet al., 2016, Aptamer-conjugated, fluorescent gold nanorods as potential cancer theradiagnostic agents, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, Vol: 59, Pages: 324-332, ISSN: 0928-4931

JOURNAL ARTICLE

Hu Y, Sharma S, Weatherwax J, Cass A, Georgiou Pet al., 2016, Live Demonstration: A Portable Multi-Channel Potentiostat for Real-Time Amperometric Measurement of Multi-Electrode Sensor Arrays, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 2373-2373, ISSN: 0271-4302

CONFERENCE PAPER

Hu Y, Sharma S, Weatherwax J, Cass A, Georgiou Pet al., 2016, A Portable Multi-Channel Potentiostat for Real-Time Amperometric Measurement of Multi-Electrode Sensor Arrays, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 1306-1309, ISSN: 0271-4302

CONFERENCE PAPER

Nabavi E, Singh M, Zhou Y, Gallina ME, Zhao H, Ma D, Cass A, Hanna G, Elson DSet al., 2016, Preliminary studies of fluorescence image-guided photothermal therapy of human oesophageal adenocarcinoma in vivo using multifunctional gold nanorods, Conference on Optical Methods for Tumor Treatment and Detection - Mechanisms and Techniques in Photodynamic Therapy XXV, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X

CONFERENCE PAPER

Sharma S, Huang Z, Rogers M, Boutelle M, Cass AEGet al., 2016, Evaluation of a minimally invasive glucose biosensor for continuous tissue monitoring, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol: 408, Pages: 8427-8435, ISSN: 1618-2642

JOURNAL ARTICLE

Singh M, Harris-Birtill DCC, Zhou Y, Gallina ME, Cass AEG, Hanna GB, Elson DSet al., 2016, Application of Gold Nanorods for Photothermal Therapy in Ex Vivo Human Oesophagogastric Adenocarcinoma, JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, Vol: 12, Pages: 481-490, ISSN: 1550-7033

JOURNAL ARTICLE

Singh M, Nabavi E, Zhou Y, Zhao H, Ma D, Cass AEG, Hanna GB, Elson DSet al., 2016, Application of gold nanorods for upper gastrointestinal cancer theranostics, Annual Meeting of the Society-of-Academic-and-Research-Surgery (SARS), Publisher: WILEY-BLACKWELL, Pages: 46-46, ISSN: 0007-1323

CONFERENCE PAPER

Chumphukam O, Le TT, Piletsky S, Cass AEGet al., 2015, Generation of a pair of independently binding DNA aptamers in a single round of selection using proximity ligation, CHEMICAL COMMUNICATIONS, Vol: 51, Pages: 9050-9053, ISSN: 1359-7345

JOURNAL ARTICLE

Lawrance D, Williamson C, Boutelle MG, Cass AEGet al., 2015, Development of a disposable bile acid biosensor for use in the management of cholestasis, ANALYTICAL METHODS, Vol: 7, Pages: 3714-3719, ISSN: 1759-9660

JOURNAL ARTICLE

Maniyam MN, Sjahrir F, Ibrahim AL, Cass AEGet al., 2015, Enzymatic cyanide degradation by cell-free extract of Rhodococcus UKMP-5M, JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING, Vol: 50, Pages: 357-364, ISSN: 1093-4529

JOURNAL ARTICLE

Moreira FTC, Sharma S, Dutra RAF, Noronha JPC, Cass AEG, Sales MGFet al., 2015, Detection of cardiac biomarker proteins using a disposable based on a molecularly imprinted polymer grafted onto graphite, MICROCHIMICA ACTA, Vol: 182, Pages: 975-983, ISSN: 0026-3672

JOURNAL ARTICLE

Perevedentsev A, Sonnefraud Y, Belton CR, Sharma S, Cass AEG, Maier SA, Kim J-S, Stavrinou PN, Bradley DDCet al., 2015, Dip-pen patterning of poly( 9,9-dioctylfluorene) chain-conformation-based nano-photonic elements, NATURE COMMUNICATIONS, Vol: 6, ISSN: 2041-1723

JOURNAL ARTICLE

Sharma S, El-Laboudi A, Oliver N, Johnston D, Cass Tet al., 2015, EVALUATION AND IMPROVEMENT OF EPOXY POLYURETHANE MEMBRANE FOR A MICROPROBE ARRAY BASED CONTINUOUS GLUCOSE SENSOR, DIABETES TECHNOLOGY & THERAPEUTICS, Vol: 17, Pages: A90-A91, ISSN: 1520-9156

JOURNAL ARTICLE

Singh M, Nabavi E, Zhou Y, Zhao H, Ma D, Cass AE, Hanna GB, Elson DSet al., 2015, APPLICATION OF GOLD NANORODS FOR IN VIVO THERANOSTICS OF HUMAN OESOPHAGEAL ADENOCARCINOMA, 2nd Digestive-Disorders-Federation Conference, Publisher: BMJ PUBLISHING GROUP, Pages: A471-A471, ISSN: 0017-5749

CONFERENCE PAPER

Chumphukam O, Le TT, Cass AEG, 2014, High Efficiency Acetylcholinesterase Immobilization on DNA Aptamer Modified Surfaces, MOLECULES, Vol: 19, Pages: 4986-4996, ISSN: 1420-3049

JOURNAL ARTICLE

El-Laboudi A, Sharma S, Oliver N, Hussein T, Patel D, Johnston D, Cass Tet al., 2014, DEVELOPMENT OF A NOVEL MICROPROBE ARRAY CONTINUOUS GLUCOSE SENSOR FOR TYPE 1 DIABETES: INTERFERENCE STUDIES, DIABETES TECHNOLOGY & THERAPEUTICS, Vol: 16, Pages: A65-A66, ISSN: 1520-9156

JOURNAL ARTICLE

Harris-Birtill D, Singh M, Zhou Y, Elena-Gallina M, Cass T, Elson Det al., 2014, Gold Nanorod Reshaping using a Continuous Wave Laser, Conference on Lasers and Electro-Optics (CLEO), Publisher: IEEE, ISSN: 2160-9020

CONFERENCE PAPER

Le TT, Adamiak B, Benton DJ, Johnson CJ, Sharma S, Fenton R, McCauley JW, Iqbal M, Cass AEGet al., 2014, Aptamer-based biosensors for the rapid visual detection of flu viruses, CHEMICAL COMMUNICATIONS, Vol: 50, Pages: 15533-15536, ISSN: 1359-7345

JOURNAL ARTICLE

Le TT, Chumphukam O, Cass AEG, 2014, Determination of minimal sequence for binding of an aptamer. A comparison of truncation and hybridization inhibition methods, RSC ADVANCES, Vol: 4, Pages: 47227-47233, ISSN: 2046-2069

JOURNAL ARTICLE

Maniyam MN, Sjahrir F, Ibrahim AL, Cass AEGet al., 2014, Biodetoxification of cyanide-containing industrial wastewaters by Rhodococcus UKMP-5M, BIOLOGIA, Vol: 69, Pages: 1635-1643, ISSN: 0006-3088

JOURNAL ARTICLE

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: respub-action=search.html&id=00000985&limit=30&person=true