Imperial College London

Professor Tony Cass

Faculty of Natural SciencesDepartment of Chemistry

Professor of Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 5195t.cass

 
 
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Location

 

6.23Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

197 results found

Cass AEG, Sharma S, 2017, Microneedle Enzyme Sensor Arrays for Continuous In Vivo Monitoring, ENZYMES AS SENSORS, Vol: 589, Pages: 413-427, ISSN: 0076-6879

JOURNAL ARTICLE

Harris-Birtill D, Singh M, Zhou Y, Shah A, Ruenraroengsak P, Gallina ME, Hanna GB, Cass AEG, Porter AE, Bamber J, Elson DSet al., 2017, Gold nanorod reshaping in vitro and in vivo using a continuous wave laser, PLOS ONE, Vol: 12, ISSN: 1932-6203

JOURNAL ARTICLE

Le TT, Chang P, Benton DJ, McCauley JW, Iqbal M, Cass AEGet al., 2017, Dual Recognition Element Lateral Flow Assay Toward Multiplex Strain Specific Influenza Virus Detection, ANALYTICAL CHEMISTRY, Vol: 89, Pages: 6781-6786, ISSN: 0003-2700

JOURNAL ARTICLE

Maniyam MN, Ibrahim AL, Cass AEG, 2017, Enhanced cyanide biodegradation by immobilized crude extract of Rhodococcus UKMP-5M., Environ Technol, Pages: 1-13, ISSN: 0959-3330

The capability of the crude extract of Rhodococcus UKMP-5M was enhanced by adopting the technology of immobilization. Among the matrices screened to encapsulate the crude extract, gellan gum emerged as the most suitable immobilization material, exceeding the activity of cyanide-degrading enzyme by 61% and 361% in comparison to alginate carrier and non-immobilized crude extract, respectively. Improved bead mechanical strength which supported higher biocatalyst activity by 63% was observed when concentration of gellan gum, concentration of calcium chloride, number of beads and bead size were optimized. The immobilized crude extract demonstrated higher tolerance towards broad range of pH (5-10) and temperature (30°C-40°C), superior cyanide-degrading activity over time and improved storage stability by maintaining 76% of its initial activity after 30 days at 4°C. Furthermore, repeated use of the gellan gum beads up to 20 batches without substantial loss in the catalytic activity was documented in the present study, indicating that the durability of the beads and the stability of the enzyme are both above adequate. Collectively, the findings reported here revealed that the utilization of the encapsulated crude extract of Rhodococcus UKMP-5M can be considered as a novel attempt to develop an environmentally favourable and financially viable method in cyanide biodegradation.

JOURNAL ARTICLE

Rawson TM, O'Hare D, Herrero P, Sharma S, Moore LSP, de Barra E, Roberts JA, Gordon AC, Hope W, Georgiou P, Cass AEG, Holmes AHet al., 2017, Delivering precision antimicrobial therapy through closed-loop control systems., J Antimicrob Chemother

Sub-optimal exposure to antimicrobial therapy is associated with poor patient outcomes and the development of antimicrobial resistance. Mechanisms for optimizing the concentration of a drug within the individual patient are under development. However, several barriers remain in realizing true individualization of therapy. These include problems with plasma drug sampling, availability of appropriate assays, and current mechanisms for dose adjustment. Biosensor technology offers a means of providing real-time monitoring of antimicrobials in a minimally invasive fashion. We report the potential for using microneedle biosensor technology as part of closed-loop control systems for the optimization of antimicrobial therapy in individual patients.

JOURNAL ARTICLE

Rawson TM, Sharma S, Georgiou P, Holmes A, Cass A, O'Hare Det al., 2017, Towards a minimally invasive device for beta-lactam monitoring in humans, ELECTROCHEMISTRY COMMUNICATIONS, Vol: 82, Pages: 1-5, ISSN: 1388-2481

JOURNAL ARTICLE

Sharma S, Saeed A, Johnson C, Gadegaard N, Cass AEet al., 2017, Rapid, low cost prototyping of transdermal devices for personal healthcare monitoring., Sens Biosensing Res, Vol: 13, Pages: 104-108, ISSN: 2214-1804

The next generation of devices for personal healthcare monitoring will comprise molecular sensors to monitor analytes of interest in the skin compartment. Transdermal devices based on microneedles offer an excellent opportunity to explore the dynamics of molecular markers in the interstitial fluid, however good acceptability of these next generation devices will require several technical problems associated with current commercially available wearable sensors to be overcome. These particularly include reliability, comfort and cost. An essential pre-requisite for transdermal molecular sensing devices is that they can be fabricated using scalable technologies which are cost effective. We present here a minimally invasive microneedle array as a continuous monitoring platform technology. Method for scalable fabrication of these structures is presented. The microneedle arrays were characterised mechanically and were shown to penetrate human skin under moderate thumb pressure. They were then functionalised and evaluated as glucose, lactate and theophylline biosensors. The results suggest that this technology can be employed in the measurement of metabolites, therapeutic drugs and biomarkers and could have an important role to play in the management of chronic diseases.

JOURNAL ARTICLE

Sharma S, Takagi E, Cass T, Tsugawa W, Sode Ket al., 2017, Minimally invasive microneedle array electrodes employing direct electron transfer type glucose dehydrogenase for the development of continuous glucose monitoring sensors, BIOSENSORS 2016, Vol: 27, Pages: 208-209, ISSN: 2212-0173

JOURNAL ARTICLE

Sze JYY, Ivanov AP, Cass AEG, Edel JBet al., 2017, Single molecule multiplexed nanopore protein screening in human serum using aptamer modified DNA carriers, NATURE COMMUNICATIONS, Vol: 8, ISSN: 2041-1723

JOURNAL ARTICLE

Gallina ME, Zhou Y, Johnson CJ, Harris-Birtill D, Singh M, Zhao H, Ma D, Cass T, Elson DSet al., 2016, Aptamer-conjugated, fluorescent gold nanorods as potential cancer theradiagnostic agents, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, Vol: 59, Pages: 324-332, ISSN: 0928-4931

JOURNAL ARTICLE

Hu Y, Sharma S, Weatherwax J, Cass A, Georgiou Pet al., 2016, Live Demonstration: A Portable Multi-Channel Potentiostat for Real-Time Amperometric Measurement of Multi-Electrode Sensor Arrays, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 2373-2373, ISSN: 0271-4302

CONFERENCE PAPER

Hu Y, Sharma S, Weatherwax J, Cass A, Georgiou Pet al., 2016, A Portable Multi-Channel Potentiostat for Real-Time Amperometric Measurement of Multi-Electrode Sensor Arrays, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 1306-1309, ISSN: 0271-4302

CONFERENCE PAPER

Nabavi E, Singh M, Zhou Y, Gallina ME, Zhao H, Ma D, Cass A, Hanna G, Elson DSet al., 2016, Preliminary studies of fluorescence image-guided photothermal therapy of human oesophageal adenocarcinoma in vivo using multifunctional gold nanorods, Conference on Optical Methods for Tumor Treatment and Detection - Mechanisms and Techniques in Photodynamic Therapy XXV, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X

CONFERENCE PAPER

Sharma S, Huang Z, Rogers M, Boutelle M, Cass AEGet al., 2016, Evaluation of a minimally invasive glucose biosensor for continuous tissue monitoring, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol: 408, Pages: 8427-8435, ISSN: 1618-2642

JOURNAL ARTICLE

Singh M, Harris-Birtill DCC, Zhou Y, Gallina ME, Cass AEG, Hanna GB, Elson DSet al., 2016, Application of Gold Nanorods for Photothermal Therapy in Ex Vivo Human Oesophagogastric Adenocarcinoma, JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, Vol: 12, Pages: 481-490, ISSN: 1550-7033

JOURNAL ARTICLE

Singh M, Nabavi E, Zhou Y, Zhao H, Ma D, Cass A, Hanna GB, Elson Det al., 2016, Application of Gold Nanorods in Cancer Theranostics, 57th Annual Meeting and Residents Fellow Conference of the Society-for-Surgery-of-the-Alimentary-Tract (SSAT) / 52nd Annual Meeting on Digestive Disease Week (DDW) / Meeting of the American-Gastroenterological-Association (AGA), Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: S1177-S1177, ISSN: 0016-5085

CONFERENCE PAPER

Singh M, Nabavi E, Zhou Y, Zhao H, Ma D, Cass AEG, Hanna GB, Elson DSet al., 2016, Application of gold nanorods for upper gastrointestinal cancer theranostics, Annual Meeting of the Society-of-Academic-and-Research-Surgery (SARS), Publisher: WILEY-BLACKWELL, Pages: 46-46, ISSN: 0007-1323

CONFERENCE PAPER

Chumphukam O, Le TT, Piletsky S, Cass AEGet al., 2015, Generation of a pair of independently binding DNA aptamers in a single round of selection using proximity ligation, CHEMICAL COMMUNICATIONS, Vol: 51, Pages: 9050-9053, ISSN: 1359-7345

JOURNAL ARTICLE

Lawrance D, Williamson C, Boutelle MG, Cass AEGet al., 2015, Development of a disposable bile acid biosensor for use in the management of cholestasis, ANALYTICAL METHODS, Vol: 7, Pages: 3714-3719, ISSN: 1759-9660

JOURNAL ARTICLE

Maniyam MN, Sjahrir F, Ibrahim AL, Cass AEGet al., 2015, Enzymatic cyanide degradation by cell-free extract of Rhodococcus UKMP-5M, JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING, Vol: 50, Pages: 357-364, ISSN: 1093-4529

JOURNAL ARTICLE

Moreira FTC, Sharma S, Dutra RAF, Noronha JPC, Cass AEG, Sales MGFet al., 2015, Detection of cardiac biomarker proteins using a disposable based on a molecularly imprinted polymer grafted onto graphite, MICROCHIMICA ACTA, Vol: 182, Pages: 975-983, ISSN: 0026-3672

JOURNAL ARTICLE

Perevedentsev A, Sonnefraud Y, Belton CR, Sharma S, Cass AEG, Maier SA, Kim J-S, Stavrinou PN, Bradley DDCet al., 2015, Dip-pen patterning of poly( 9,9-dioctylfluorene) chain-conformation-based nano-photonic elements, NATURE COMMUNICATIONS, Vol: 6, ISSN: 2041-1723

JOURNAL ARTICLE

Sharma S, El-Laboudi A, Oliver N, Johnston D, Cass Tet al., 2015, EVALUATION AND IMPROVEMENT OF EPOXY POLYURETHANE MEMBRANE FOR A MICROPROBE ARRAY BASED CONTINUOUS GLUCOSE SENSOR, DIABETES TECHNOLOGY & THERAPEUTICS, Vol: 17, Pages: A90-A91, ISSN: 1520-9156

JOURNAL ARTICLE

Singh M, Nabavi E, Zhou Y, Zhao H, Ma D, Cass AE, Hanna GB, Elson DSet al., 2015, APPLICATION OF GOLD NANORODS FOR IN VIVO THERANOSTICS OF HUMAN OESOPHAGEAL ADENOCARCINOMA, 2nd Digestive-Disorders-Federation Conference, Publisher: BMJ PUBLISHING GROUP, Pages: A471-A471, ISSN: 0017-5749

CONFERENCE PAPER

Chumphukam O, Le TT, Cass AEG, 2014, High Efficiency Acetylcholinesterase Immobilization on DNA Aptamer Modified Surfaces, MOLECULES, Vol: 19, Pages: 4986-4996, ISSN: 1420-3049

JOURNAL ARTICLE

El-Laboudi A, Sharma S, Oliver N, Hussein T, Patel D, Johnston D, Cass Tet al., 2014, DEVELOPMENT OF A NOVEL MICROPROBE ARRAY CONTINUOUS GLUCOSE SENSOR FOR TYPE 1 DIABETES: INTERFERENCE STUDIES, DIABETES TECHNOLOGY & THERAPEUTICS, Vol: 16, Pages: A65-A66, ISSN: 1520-9156

JOURNAL ARTICLE

Harris-Birtill D, Singh M, Zhou Y, Elena-Gallina M, Cass T, Elson Det al., 2014, Gold Nanorod Reshaping using a Continuous Wave Laser, Conference on Lasers and Electro-Optics (CLEO), Publisher: IEEE, ISSN: 2160-9020

CONFERENCE PAPER

Le TT, Adamiak B, Benton DJ, Johnson CJ, Sharma S, Fenton R, McCauley JW, Iqbal M, Cass AEGet al., 2014, Aptamer-based biosensors for the rapid visual detection of flu viruses, CHEMICAL COMMUNICATIONS, Vol: 50, Pages: 15533-15536, ISSN: 1359-7345

JOURNAL ARTICLE

Le TT, Chumphukam O, Cass AEG, 2014, Determination of minimal sequence for binding of an aptamer. A comparison of truncation and hybridization inhibition methods, RSC ADVANCES, Vol: 4, Pages: 47227-47233, ISSN: 2046-2069

JOURNAL ARTICLE

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