Imperial College London
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Professor Tony Cass

Faculty of Natural Sciences, Department of Chemistry

Senior Research Investigator
 
 
 
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Contact

 

+44 (0)20 7594 5195t.cass

 
 
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Location

 

301KMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Singh:2016:10.1166/jbn.2016.2196,
author = {Singh, M and Harris-Birtill, DCC and Zhou, Y and Gallina, ME and Cass, A and Hanna, GB and Elson, DS},
doi = {10.1166/jbn.2016.2196},
journal = {Journal of Biomedical Nanotechnology},
pages = {481--490},
title = {Application of Gold Nanorods for Photothermal Therapy in Ex Vivo Human Oesophagogastric Adenocarcinoma},
url = {http://dx.doi.org/10.1166/jbn.2016.2196},
volume = {12},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Gold nanoparticles are chemically fabricated and tuned to strongly absorb near infrared (NIR) light, enabling deep optical penetration and therapy within human tissues, where sufficient heating induces tumour necrosis. In our studies we aim to establish the optimal gold nanorod (GNR) concentration and laser power for inducing hyperthermic effects in tissues and test this photothermal effect on ex vivo human oesophagogastric adenocarcinoma. The ideal GNR concentration and NIR laser power that would elicit sufficient hyperthermia for tumour necrosis was pre-determined on porcine oesophageal tissues. Human ex vivo oesophageal and gastric adenocarcinoma tissues were incubated with GNR solutions and a GNR-free control solution with corresponding healthy tissues for comparison, then irradiated with NIR light for 10 minutes. Temperature rise was found to vary linearly with both the concentration of GNRs and the laser power. Human ex vivo oesophageal and gastric tissues consistently demonstrated a significant temperature rise when incubated in an optimally concentrated GNR solution (3 × 1010 GNRs/ml) prior to NIR irradiation delivered at an optimal power (2 W/cm2). A mean temperature rise of 27 °C was observed in tissues incubated with GNRs, whereas only a modest 2 °C rise in tissues not exposed to any GNRs. This study evaluates the photothermal effects of GNRs on oesophagogastric tissue examines their application in the minimally invasive therapeutics of oesophageal and gastric adenocarcinomas. This could potentially be an effective method of clinically inducing irreversible oesophagogastric tumour photodestruction, with minimal collateral damage expected in (healthy) tissues free from GNRs.
AU  - Singh,M
AU  - Harris-Birtill,DCC
AU  - Zhou,Y
AU  - Gallina,ME
AU  - Cass,A
AU  - Hanna,GB
AU  - Elson,DS
DO  - 10.1166/jbn.2016.2196
EP  - 490
PY  - 2016///
SN  - 1550-7041
SP  - 481
TI  - Application of Gold Nanorods for Photothermal Therapy in Ex Vivo Human Oesophagogastric Adenocarcinoma
T2  - Journal of Biomedical Nanotechnology
UR  - http://dx.doi.org/10.1166/jbn.2016.2196
UR  - http://hdl.handle.net/10044/1/23565
VL  - 12
ER  -
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