Imperial College London
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Professor Tony Cass

Faculty of Natural Sciences, Department of Chemistry

Senior Research Investigator
 
 
 
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Contact

 

+44 (0)20 7594 5195t.cass

 
 
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Location

 

301KMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Morton:2018:10.1016/j.ekir.2017.12.008,
author = {Morton, RL and Schlackow, I and Gray, A and Emberson, J and Herrington, W and Staplin, N and Reith, C and Howard, K and Landray, MJ and Cass, A and Baigent, C and Mihaylova, B},
doi = {10.1016/j.ekir.2017.12.008},
journal = {Kidney International Reports},
pages = {610--618},
title = {Impact of CKD on household income},
url = {http://dx.doi.org/10.1016/j.ekir.2017.12.008},
volume = {3},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - IntroductionThe impact of chronic kidney disease (CKD) on income is unclear. We sought to determine whether CKD severity, serious adverse events, and CKD progression affected household income.MethodsAnalyses were undertaken in a prospective cohort of adults with moderate-to-severe CKD in the Study of Heart and Renal Protection (SHARP), with household income information available at baseline screening and study end. Logistic regressions, adjusted for sociodemographic characteristics, smoking, and prior diseases at baseline, estimated associations during the 5-year follow-up, among (i) baseline CKD severity, (ii) incident nonfatal serious adverse events (vascular or cancer), and (iii) CKD treatment modality (predialysis, dialysis, or transplanted) at study end and the outcome “fall into relative poverty.” This was defined as household income <50% of country median income.ResultsA total of 2914 SHARP participants from 14 countries were included in the main analysis. Of these, 933 (32%) were in relative poverty at screening; of the remaining 1981, 436 (22%) fell into relative poverty by study end. Compared with participants with stage 3 CKD at baseline, the odds of falling into poverty were 51% higher for those with stage 4 (odds ratio [OR]: 1.51; 95% confidence interval [CI]: 1.09–2.10), 66% higher for those with stage 5 (OR: 1.66; 95% CI: 1.11–2.47), and 78% higher for those on dialysis at baseline (OR: 1.78, 95% CI: 1.22–2.60). Participants with kidney transplant at study end had approximately half the risk of those on dialysis or those with CKD stages 3 to 5.ConclusionMore advanced CKD is associated with increased odds of falling into poverty. Kidney transplantation may have a role in reducing this risk.
AU  - Morton,RL
AU  - Schlackow,I
AU  - Gray,A
AU  - Emberson,J
AU  - Herrington,W
AU  - Staplin,N
AU  - Reith,C
AU  - Howard,K
AU  - Landray,MJ
AU  - Cass,A
AU  - Baigent,C
AU  - Mihaylova,B
DO  - 10.1016/j.ekir.2017.12.008
EP  - 618
PY  - 2018///
SN  - 2468-0249
SP  - 610
TI  - Impact of CKD on household income
T2  - Kidney International Reports
UR  - http://dx.doi.org/10.1016/j.ekir.2017.12.008
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000432471300013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/60611
VL  - 3
ER  -
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