Imperial College London

Dr Timothy Constandinou

Faculty of EngineeringDepartment of Electrical and Electronic Engineering

Reader in Neural Microsystems
 
 
 
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Contact

 

+44 (0)20 7594 0790t.constandinou Website

 
 
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Assistant

 

Miss Izabela Wojcicka-Grzesiak +44 (0)20 7594 0701

 
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Location

 

B407Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

143 results found

Constandinou TG, Jackson A, 2017, Implantable Neural Interface

A neural interface arrangement comprising: a plurality of probes for subdural implantation into or onto a human brain, each probe including at least one sensing electrode, a coil for receiving power via inductive coupling, signal processing circuitry coupled to the sensing electrode(s), and means for wirelessly transmitting data-carrying signals arising from the sensing electrode(s); an array of coils for implantation above the dura, beneath the skull, the array of coils being for inductively coupling with the coil of each of the plurality of probes, for transmitting power to the probes; and a primary (e.g. subcutaneous) coil connected to the array of coils, the primary coil being for inductively coupling with an external transmitter device, for receiving power from the external transmitter device; wherein, in use, the primary coil is operable to receive power from the external transmitter device by inductive coupling and to cause the array of coils to transmit power to the plurality of probes by inductive coupling; and wherein, in use, the plurality of probes are operable to wirelessly transmit data-carrying signals arising from the sensing electrodes.

PATENT

Dávila-Montero S, Barsakcioglu DY, Jackson A, Constandinou TG, Mason AJet al., 2017, Real-time clustering algorithm that adapts to dynamic changes in neural recordings, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 690-693

This work presents a computationally efficient real-time adaptive clustering algorithm that recognizes and adapts to dynamic changes observed in neural recordings. The algorithm consists of an off-line training phase that determines initial cluster positions, and an on-line operation phase that continuously tracks drifts in clusters and periodically verifies acute changes in cluster composition. Analysis of chronic recordings from non-human primates shows that adaptive clustering achieves an improvement of 14% in classification accuracy and demonstrates an ability to recognize acute changes with 78% accuracy, with up to 29% computational efficiency compared to the state-of-the-art. The presented algorithm is suitable for long-term chronic monitoring of neural activity in various applications such as neuroscience research and control of neural prosthetics and assistive devices.

CONFERENCE PAPER

De Marcellis A, Palange E, Faccio M, Stanchieri GDP, Constandinou TGet al., 2017, A 250Mbps 24pJ/bit UWB-inspired Optical Communication System for Bioimplants, Turin, Italy, IEEE Biomedical Circuits and Systems (BioCAS) Conference, Pages: 132-135

CONFERENCE PAPER

Feng P, Constandinou TG, Yeon P, Ghovanloo Met al., 2017, Millimeter-Scale Integrated and Wirewound Coils for Powering Implantable Neural Microsystems, IEEE Biomedical Circuits and Systems (BioCAS) Conference, Pages: 488-491

CONFERENCE PAPER

Gao C, Ghoreishizadeh S, Liu Y, Constandinou TGet al., 2017, On-chip ID generation for multi-node implantable devices using SA-PUF, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 678-681

This paper presents a 64-bit on-chip identification system featuring low power consumption and randomness compensation for multi-node bio-implantable devices. A sense amplifier based bit-cell is proposed to realize the silicon physical unclonable function, providing a unique value whose probability has a uniform distribution and minimized influence from the temperature and supply variation. The entire system is designed and implemented in a typical 0.35 m CMOS technology, including an array of 64 bit-cells, readout circuits, and digital controllers for data interfaces. Simulated results show that the proposed bit-cell design achieved a uniformity of 50.24% and a uniqueness of 50.03% for generated IDs. The system achieved an energy consumption of 6.0 pJ per bit with parallel outputs and 17.3 pJ per bit with serial outputs.

CONFERENCE PAPER

Ghoreishizadeh S, Constandinou TG, 2017, On-chip Random ID Generation

PATENT

Ghoreishizadeh S, Haci D, Liu Y, Donaldson N, Constandinou TGet al., 2017, Four-Wire Interface ASIC for a Multi-Implant Link, IEEE Transactions on Circuits and Systems I: Regular Papers, Vol: 64, Pages: 3056-3067, ISSN: 1549-8328

This paper describes an on-chip interface for recovering power and providing full-duplex communication over an AC-coupled 4-wire lead between active implantable devices. The target application requires two modules to be implanted in the brain (cortex) and upper chest; connected via a subcutaneous lead. The brain implant consists of multiple identical ‘optrodes’ that facilitate a bidirectional neural interface (electrical recording, optical stimulation), and chest implant contains the power source (battery) and processor module. The proposed interface is integrated within each optrode ASIC allowing full-duplex and fully-differential communication based on Manchester encoding. The system features a head-to-chest uplink data rate(up to 1.6 Mbps) that is higher than that of the chest-to-head downlink (100 kbps) which is superimposed on a power carrier. On-chip power management provides an unregulated 5V DC supply with up to 2.5mA output current for stimulation, and two regulated voltages (3.3V and 3V) with 60 dB PSRR for recording and logic circuits. The 4-wire ASIC has been implemented in a 0.35 um CMOS technology, occupying 1.5mm2 silicon area,and consumes a quiescent current of 91.2u A. The system allows power transmission with measured efficiency of up to 66% from the chest to the brain implant. The downlink and uplink communication are successfully tested in a system with two optrodes and through a 4-wire implantable lead.

JOURNAL ARTICLE

Ghoreishizadeh SS, Haci D, Liu Y, Constandinou TGet al., 2017, A 4-Wire Interface SoC for Shared Multi- Implant Power Transfer and Full-duplex Communication, 8th IEEE Latin American Symposium on Circuits & Systems (LASCAS), Publisher: IEEE

CONFERENCE PAPER

Guven O, Eftekhar A, Kindt W, Constandinou TGet al., 2017, Low-power real-time ECG baseline wander removal: hardware implementation, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 1571-1574

This paper presents a hardware realisation of a novel ECG baseline drift removal that preserves the ECG signal integrity. The microcontroller implementation detects the fiducial markers of the ECG signal and the baseline wander estimation is achieved through a weighted piecewise linear interpolation. This estimated drift is then removed to recover a “clean” ECG signal without significantly distorting the ST segment. Experimental results using real data from the MIT-BIH Arrhythmia Database (recording 100 and 101) with added baseline wander (BWM1) from the MIT-BIH Noise Stress Database show an average root mean square error of 34.3uV (mean), 30.4u V (median) and 18.4uV (standard deviation) per heart beat.

CONFERENCE PAPER

Haci D, Liu Y, Constandinou TG, 2017, 32-channel ultra-low-noise arbitrary signal generation platform for biopotential emulation, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 698-701

This paper presents a multichannel, ultra-low-noise arbitrary signal generation platform for emulating a wide range of different biopotential signals (e.g. ECG, EEG, etc). This is intended for use in the test, measurement and demonstration of bioinstrumentation and medical devices that interface to electrode inputs. The system is organized in 3 key blocks for generating, processing and converting the digital data into a parallel high performance analogue output. These blocks consist of: (1) a Raspberry Pi 3 (RPi3) board; (2) a custom Field Programmable Gate Array (FPGA) board with low-power IGLOO Nano device; and (3) analogue board including the Digital-to-Analogue Converters (DACs) and output circuits. By implementing the system this way, good isolation can be achieved between the different power and signal domains. This mixed-signal architecture takes in a high bitrate SDIO (Secure Digital Input Output) stream, recodes and packetizes this to drive two multichannel DACs, with parallel analogue outputs that are then attenuated and filtered. The system achieves 32-parallel output channels each sampled at 48kS/s, with a 10kHz bandwidth, 110dB dynamic range and uV-level output noise.

CONFERENCE PAPER

Leene L, Constandinou TG, 2017, A 2.7uW/Mips, 0.88GOPS/mm^2 Distributed Processor for Implantable Brain Machine Interfaces, IEEE Biomedical Circuits and Systems (BioCAS) Conference, Publisher: IEEE, Pages: 360-363

This paper presents a scalable architecture in 0.18u m CMOS for implantable brain machine interfaces (BMI) that enables micro controller flexibility for data analysis at the sensor interface. By introducing more generic computational capabilities the system is capable of high level adaptive function to potentially improve the long term efficacy of invasive implants. This topology features a compact ultra low power distributedprocessor that supports 64-channel neural recording system on chip (SOC) with a computational efficiency of 2.7uW/MIPS with a total chip area of 1.37mm2. This configuration executes 1024 instructions on each core at 20MHz to consolidate full spectrum high precision recordings from 4 analogue channels for filtering, spike detection, and feature extraction in the digital domain.

CONFERENCE PAPER

Leene L, Constandinou TG, 2017, A 0.5V time-domain instrumentation circuit with clocked and unclocked ΔΣ operation, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 2619-2622, ISSN: 2379-447X

This paper presents a time-domain instrumentation circuit with exceptional noise efficiency directed at using nanometre CMOS for next generation neural interfaces. Current efforts to realize closed loop neuromodulation and high fidelity BMI prosthetics rely extensively on digital processing which isnot well integrated with conventional analogue instrumentation. The proposed time-domain topology employs a differential ring oscillator that is put into feedback using a chopper stabilized low noise transconductor and capacitive feedback. This realization promises better digital integration by extensively using time encoded digital signals and seamlessly allows both clocked & unclocked ΔΣ behavior which is useful on-chip characterizationand interfacing with synchronous systems. A 0.5V instrumentation system is implemented using a 65nm TSMC technology to realize a highly compact footprint that is 0.006mm2 in size. Simulation results demonstrate an excess of 55 dB dynamic range with 3.5 Vrms input referred noise for the given 810nW total system power budget corresponding to an NEF of 1.64.

CONFERENCE PAPER

Leene L, Constandinou TG, 2017, A 0.016² 12b ΔΣSAR With 14fJ/conv. for ultra low power biosensor arrays, IEEE Transactions on Circuits and Systems. Part 1: Regular Papers, Vol: 64, Pages: 2655-2665, ISSN: 1549-8328

The instrumentation systems for implantable brain-machine interfaces represent one of the most demanding applications for ultra low-power analogue-to-digital-converters (ADC) to date. To address this challenge, this paper proposes a ΔΣSAR topology for very large sensor arrays that allows an exceptional reduction in silicon footprint by using a continuous time 0-2 MASH topology. This configuration uses a specialized FIR window to decimate the ΔΣ modulator output and reject mismatch errors from the SAR quantizer, which mitigates the overhead from dynamic element matching techniques commonly used to achieve high precision. A fully differential prototype was fabricated using 0.18 μm CMOS to demonstrate 10.8 ENOB precision with a 0.016 mm² silicon footprint. Moreover, a 14 fJ/conv figure-of-merit can be achieved, while resolving signals with the maximum input amplitude of ±1.2,Vpp sampled at 200 kS/s. The ADC topology exhibits a number of promising characteristics for both high speed and ultra low-power systems due to the reduced complexity, switching noise, sampling load, and oversampling ratio, which are critical parameters for many sensor applications.

JOURNAL ARTICLE

Leene L, Constandinou TG, 2017, Time Domain Processing Techniques Using Ring Oscillator-Based Filter Structures, IEEE Transactions on Circuits and Systems I: Regular Papers, Vol: 64, Pages: 3003-3012, ISSN: 1549-8328

The ability to process time-encoded signals with high fidelity is becoming increasingly important for the time domain (TD) circuit techniques that are used at the advanced nanometer technology nodes. This paper proposes a compact oscillator-based subsystem that performs precise filtering of asynchronous pulse-width modulation encoded signals and makes extensive use of digital logic, enabling low-voltage operation. First- and second-order primitives are introduced that can be used as TD memory or to enable analogue filtering of TD signals. These structures can be modeled precisely to realize more advanced linear or nonlinear functionality using an ensemble of units. This paper presents the measured results of a prototype fabricated using a 65-nm CMOS technology to realize a fourth- order low-pass Butterworth filter. The system utilizes a 0.5-V supply voltage with asynchronous digital control for closed-loop operation to achieve a 73-nW power budget. The implemented filter achieves a maximum signal to noise and distortion ratio of 53 dB with a narrow 5-kHz bandwidth resulting in an figure- of-merit of 8.2 fJ/pole. With this circuit occupying a compact 0.004-mm2 silicon footprint, this technique promises a substantial reduction in size over conventional Gm-C filters, whilst addition- ally offering direct integration with digital systems.

JOURNAL ARTICLE

Liu Y, L Pereira J, Constandinou T, 2017, Event-driven processing for hardware-efficient neural spike sorting., J Neural Eng

The prospect of real-time and on-node spike sorting provides a genuine opportunity to push the envelope for large-scale integration of neural recording systems. In such systems the hardware resource, power requirements and data bandwidth increase linearly with channel count. Event-based (or data-driven) processing can here provide a new efficient means for hardware implementation that is completely activity dependant. In this work, we investigate using continuous time level-crossing sampling for efficient data representation and subsequent spike processing. We first compare signals (using synthetic neural datasets) that are encoded using this technique against conventional sampling. It is observed that considerably lower data rates are achievable when utilising 7 bits or less to represent the signals, whilst maintaining the signal fidelity. We then show how such a representation can be directly exploited by extracting simple time domain features from the bitstream to perform neural spike sorting. The proposed method is implemented in a low power FPGA platform to demonstrate the hardware viability. Results obtained using both MATLAB and reconfigurable logic (FPGA) hardware indicate that feature extraction and spike sorting accuracies can be achieved with comparable or better accuracy than reference methods whilst also requiring relatively low hardware cost.

JOURNAL ARTICLE

Liu Y, Luan S, Williams I, Rapeaux A, Constandinou TGet al., 2017, A 64-Channel Versatile Neural Recording SoC with Activity Dependant Data Throughput, IEEE Transactions on Biomedical Circuits and Systems, ISSN: 1932-4545

Modern microtechnology is enabling the channel count of neural recording integrated circuits to scale exponentially. However, the raw data bandwidth of these systems is increasing proportionately, presenting major challenges in terms of power consumption and data transmission (especially for wireless systems). This paper presents a system that exploits the sparse nature of neural signals to address these challenges and provides a reconfigurable low-bandwidth event-driven output. Specifically, we present a novel 64-channel low noise (2.1μVrms, low power (23μW per analogue channel) neural recording system-on-chip (SoC). This features individually-configurable channels, 10-bit analogue-to-digital conversion, digital filtering, spike detection, and an event-driven output. Each channel's gain, bandwidth & sampling rate settings can be independently configured to extract Local Field Potentials (LFPs) at a low data-rate and/or Action Potentials (APs) at a higher data rate. The sampled data is streamed through an SRAM buffer that supports additional on-chip processing such as digital filtering and spike detection. Real-time spike detection can achieve ~2 orders of magnitude data reduction, by using a dual polarity simple threshold to enable an event driven output for neural spikes (16-sample window). The SoC additionally features a latency-encoded asynchronous output that is critical if used as part of a closed-loop system. This has been specifically developed to complement a separate on-node spike sorting co-processor to provide a real-time (low latency) output. The system has been implemented in a commercially-available 0.35μm CMOS technology occupying a silicon area of 19.1mm² (0.3mm² gross per channel), demonstrating a low power & efficient architecture which could be further optimised by aggressive technology and supply voltage scaling.

JOURNAL ARTICLE

Luan S, Williams I, De-Carvalho F, Grand L, Jackson A, Quian Quiroga R, Constandinou TGet al., 2017, Standalone headstage for neural recording with real-time spike sorting and data logging, BNA Festival of Neuroscience, Publisher: The British Neuroscience Association Ltd

CONFERENCE PAPER

Luo J, Firfilionis D, Ramezani R, Dehkhoda F, Soltan A, Degenaar P, Liu Y, Constandinou TGet al., 2017, Live demonstration: a closed-loop cortical brain implant for optogenetic curing epilepsy, IEEE Biomedical Circuits and Systems (BioCAS) Conference, Publisher: IEEE, Pages: 169-169

CONFERENCE PAPER

Maslik M, Liu Y, Lande TS, Constandinou TGet al., 2017, A charge-based ultra-low power continuous-time ADC for data driven neural spike processing, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 1420-1423

The paper presents a novel topology of a continuous-time analogue-to-digital converter (CT-ADC) featuring ultra-low static power consumption, activity-dependent dynamic consumption, and a compact footprint. This is achieved by utilising a novel charge-packet based threshold generation method, that alleviates the requirement for a conventional feedback DAC. The circuit has a static power consumption of 3.75uW, with dynamic energy of 1.39pJ/conversion level. This type of converter is thus particularly well-suited for biosignals that are generally sparse in nature. The circuit has been optimised for neural spike recording by capturing a 3kHz bandwidth with 8-bit resolution. For a typical extracellular neural recording the average power consumption is in the order of ~4uW. The circuit has been implemented in a commercially available 0.35um CMOS technology with core occupying a footprint of 0.12 sq.mm

CONFERENCE PAPER

Mifsud A, Haci D, Ghoreishizadeh S, Liu Y, Constandinou TGet al., 2017, Adaptive Power Regulation and Data Delivery for Multi-Module Implants, IEEE Biomedical Circuits and Systems (BioCAS) Conference, Publisher: IEEE, Pages: 584-587

CONFERENCE PAPER

Szostak K, Grand L, Constandinou TG, 2017, Neural interfaces for intracortical recording: requirements, fabrication methods, and characteristics, Frontiers in Neuroscience, Vol: 11, Pages: 1-27, ISSN: 1662-4548

Implantable neural interfaces for central nervous system research have been designed with wire, polymer or micromachining technologies over the past 70 years. Research on biocompatible materials, ideal probe shapes and insertion methods has resulted in building more and more capable neural interfaces. Although the trend is promising, the long-term reliability of such devices has not yet met the required criteria for chronic human application. The performance of neural interfaces in chronic settings often degrades due to foreign body response to the implant that is initiated by the surgical procedure, and related to the probe structure, and material properties used in fabricating the neural interface. In this review, we identify the key requirements for neural interfaces for intracortical recording, describe the three different types of probes- microwire, micromachined and polymer-based probes; their materials, fabrication methods, and discuss their characteristics and related challenges.

JOURNAL ARTICLE

Szostak K, Mazza F, Maslik M, Feng P, Leene L, Constandinou TGet al., 2017, Microwire-CMOS Integration of mm-Scale Neural Probes for Chronic Local Field Potential Recording, IEEE Biomedical Circuits and Systems (BioCAS) Conference, Publisher: IEEE, Pages: 492-495

CONFERENCE PAPER

Troiani F, Nikolic K, Constandinou TG, 2017, Optical coherence tomography for compound action potential detection: a computational study, SPIE/OSA European Conferences on Biomedical Optics (ECBO), Pages: 1-3

The feasibility of using time domain optical coherence tomography (TD-OCT)to detect compound action potential in a peripheral nerve and the setup characteristics, are studied through the use of finite-difference time-domain (FDTD) technique.

CONFERENCE PAPER

Barsakcioglu DY, Constandinou TG, 2016, A 32-Channel MCU-based Feature Extraction and Classification for Scalable On-node Spike Sorting, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 1310-1313, ISSN: 0271-4302

CONFERENCE PAPER

De Marcellis A, Palange E, Faccio M, Nubile L, Stanchieri GDP, Petrucci S, Constandinou Tet al., 2016, A New Optical UWB Modulation Technique for 250Mbps Wireless Link in Implantable Biotelemetry Systems, 30th Eurosensors Conference, Publisher: ELSEVIER SCIENCE BV, Pages: 1676-1680, ISSN: 1877-7058

CONFERENCE PAPER

De Marcellis A, Palange E, Nubile L, Faccio M, Stanchieri GDP, Constandinou TGet al., 2016, A Pulsed Coding Technique Based on Optical UWB Modulation for High Data Rate Low Power Wireless Implantable Biotelemetry, ELECTRONICS, Vol: 5, ISSN: 2079-9292

JOURNAL ARTICLE

Elia M, Leene LB, Constandinou TG, 2016, Continuous-Time Micropower Interface for Neural Recording Applications, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 534-537, ISSN: 0271-4302

CONFERENCE PAPER

Frehlick Z, Williams I, Constandinou TG, 2016, Improving Neural Spike Sorting Performance using Template Enhancement, 12th IEEE Biomedical Circuits and Systems Conference (BioCAS), Publisher: IEEE, Pages: 524-527, ISSN: 2163-4025

CONFERENCE PAPER

Guven O, Eftekhar A, Kindt W, Constandinou TGet al., 2016, Computationally efficient real-time interpolation algorithm for non-uniform sampled biosignals, HEALTHCARE TECHNOLOGY LETTERS, Vol: 3, Pages: 105-110, ISSN: 2053-3713

JOURNAL ARTICLE

Lauteslager T, Tommer M, Kjelgard KG, Lande TS, Constandinou TGet al., 2016, Intracranial Heart Rate Detection Using UWB Radar, 12th IEEE Biomedical Circuits and Systems Conference (BioCAS), Publisher: IEEE, Pages: 119-122, ISSN: 2163-4025

CONFERENCE PAPER

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