Imperial College London

Dr Timothy Constandinou

Faculty of EngineeringDepartment of Electrical and Electronic Engineering

Reader in Neural Microsystems
 
 
 
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Contact

 

+44 (0)20 7594 0790t.constandinou Website

 
 
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Assistant

 

Miss Izabela Wojcicka-Grzesiak +44 (0)20 7594 0701

 
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Location

 

B407Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

141 results found

Nikolic K, Serb A, Constandinou TG, 2011, An Optical Modulator in Unmodified, Commercially Available CMOS Technology, IEEE PHOTONICS TECHNOLOGY LETTERS, Vol: 23, Pages: 1115-1117, ISSN: 1041-1135

JOURNAL ARTICLE

Paraskevopoulou SE, Constandinou TG, 2011, A sub-1 mu W Neural Spike-Peak Detection and Spike-Count Rate Encoding Circuit, Annual IEEE Biomedical Circuits and Systems Conference (BioCAS) - Engineering Tomorrow's Healthcare, Publisher: IEEE, Pages: 29-32, ISSN: 2163-4025

CONFERENCE PAPER

Serb A, Nikolic K, Constandinou TG, 2011, A CMOS-based light modulator for contactless data transfer: theory and concept., Conference on Silicon Photonics VI, Publisher: SPIE-INT SOC OPTICAL ENGINEERING, ISSN: 0277-786X

CONFERENCE PAPER

Serb A, Nikolic K, Constandinou TG, 2011, Feasibility of an Electro-Optic Link for Bondpad-less CMOS Lab-on-Chips, Annual IEEE Biomedical Circuits and Systems Conference (BioCAS) - Engineering Tomorrow's Healthcare, Publisher: IEEE, Pages: 353-356, ISSN: 2163-4025

CONFERENCE PAPER

Sole M, Sanni A, Vilches A, Toumazou C, Constandinou TGet al., 2011, A Bio-Implantable Platform for Inductive Data and Power Transfer with Integrated Battery Charging, IEEE International Symposium on Circuits and Systems (ISCAS), Publisher: IEEE, Pages: 2605-2608, ISSN: 0271-4302

CONFERENCE PAPER

Woods SP, Constandinou TG, 2011, Towards a micropositioning system for targeted drug delivery in wireless capsule endoscopy, Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS), Publisher: IEEE, Pages: 7372-7375, ISSN: 1557-170X

This paper describes a novel micropositioningmechanism for achieving 1ml of targeted drug delivery within wireless capsule endoscopes. The mechanism allows a needle to be positioned within a 22.5° segment of a cylindrical capsule and be extendible by up to 4mm. The mechanism achieves both these functions using only a single micromotor and occupying a volume of just 200mm³ (including micromotor), this represents only 6.6% of the total available space. Through a detailed stress analysis it has been shown that the proposed mechanismcan be fabricated using FDA approved materials and requires a power budget of under 3.3% of the available capacity. It is envisaged this mechanism would empower a new breed of capsule microrobots for therapy in addition to diagnostics for pathologies such as ulcerative colitis and small intestinal Crohn’s disease.

CONFERENCE PAPER

Constandinou TG, Georgiou P, Prodromakis T, Toumazou Cet al., 2010, A CMOS-based lab-on-chip array for the combined magnetic stimulation and opto-chemical sensing of neural tissue

This paper presents a novel CMOS-based labon-chip platform for non-contact magnetic stimulation and recording of neural tissue. The proposed system is the first of its kind to integrate magnetic-stimulation and optochemical sensing in a single pixel, tesselated to form an 8×8 array. Fabricated in a commercially-available 0.35μm CMOS technology, the system can be intrinsically used for both optical imaging and pH sensing and includes mechanisms for calibrating out sensor variation and mismatch. In addition to sensory acquisition via an integrated 10-bit ADC, a 64-instruction spatiotemporal pattern generator has been embedded within the array for driving the microscale magnetic neural stimulation. In this application the ISFET-based sensors are used to capacitively-couple neuronal charge in close proximity to the floating gate. Optical imaging hardware has also been embedded to provide topographic detail of the neural tissue. © 2010 IEEE.

CONFERENCE PAPER

Constandinou TG, Hafliger P, 2010, Guest Editorial - Special Issue on Selected Papers from ISCAS 2009, IEEE Transactions on Biomedical Circuits and Systems, Vol: 4, Pages: 137-138, ISSN: 1932-4545

JOURNAL ARTICLE

Eftekhar A, Paraskevopoulou SE, Constandinou TG, 2010, Towards a Next Generation Neural Interface: Optimizing Power, Bandwidth and Data Quality, Biomedical Circuits and Systems Conference (BioCAS), Publisher: IEEE, Pages: 122-125, ISSN: 2163-4025

CONFERENCE PAPER

Garner DM, Bai H, Georgiou P, Constandinou TG, Reed S, Shepherd LM, Wong W, Lim KT, Toumazou Cet al., 2010, A multichannel DNA SoC for rapid point-of-care gene detection, Pages: 492-493, ISSN: 0193-6530

Point-of-care diagnostics for detection of genetic sequences require biosensing platforms that are sensitive to the target sequence, and are also fast, mass-manufacturable, and - ideally - disposable. Conventional lab-based methods of detecting DNA sequences rely on optical methods, typically by the addition of fluorescent tags to the target DNA that in turn latches onto a DNA probe sequence only if there is a match between the two. These techniques are cumbersome as they require upfront tagging of the DNA with expensive reagents and laboratory equipment to detect the optical signals. Recently, developments have been made in transferring these optical methods to inexpensive CMOS ICs [1], although the requirement for tagging remains. Magnetic beads offer an alternative means of tagging the DNA and their presence can be detected by the shift in resonant frequency of an on-chip LC tank [2] . There have also been attempts based on "label-free" electrochemical detection using FETs [3,4], but none of these have been implemented in unmodified standard CMOS. ©2010 IEEE.

CONFERENCE PAPER

Prodromakis T, Liu Y, Constandinou T, Georgiou P, Toumazou Cet al., 2010, Exploiting CMOS Technology to Enhance the Performance of ISFET Sensors, IEEE ELECTRON DEVICE LETTERS, Vol: 31, Pages: 1053-1055, ISSN: 0741-3106

JOURNAL ARTICLE

Constandinou TG, 2009, Biologically Inspired Electronics for Micropower Vision Processing, Publisher: VDM Verlag, ISBN: 978-3639133912

BOOK

Constandinou TG, Georgiou J, 2009, A Micropower Tilt-Processing Circuit, IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS, Vol: 3, Pages: 363-369, ISSN: 1932-4545

JOURNAL ARTICLE

Constandinou TG, Georgiou J, Toumazou C, 2009, A Neural Implant ASIC for the Restoration of Balance in Individuals with Vestibular Dysfunction, IEEE International Symposium on Circuits and Systems (ISCAS 2009), Publisher: IEEE, Pages: 641-+

CONFERENCE PAPER

Eftekhar A, Constandinou TG, Abbruzzese D, Woods V, Triantis IF, Drakakis EM, Toumazou Cet al., 2009, A Programmable Neural Interface for Investigating Arbitrary Stimulation Strategies, 14th Annual International FES Society Conference

CONFERENCE PAPER

Yan L, Georgiou P, Constandinou TG, Garner D, Toumazou Cet al., 2009, An Auto-Offset-Removal circuit for chemical sensing based on the PG-ISFET, IEEE International Symposium on Circuits and Systems (ISCAS 2009), Publisher: IEEE, Pages: 1165-+

CONFERENCE PAPER

Constandinou TG, Georgiou J, 2008, A Micropower Tilt Processing Circuit, IEEE Biomedical Circuits and Systems (BioCAS) Conference, Publisher: IEEE, Pages: 197-200

This paper describes a novel analogue circuit for extracting the tilt angle from the output of a standard MEMS accelerometer. The circuit uses the accelerometer signal together with the gravitational acceleration vector to generate the tilt signal. Using a current-mode representation with devices operated in subthreshold, the appropriate trigonometric function has been realised to compute tilt. Furthermore, implementing a long-time constant filter to extract the mean tilt level provides adaptation to the static tilt level. Specifically, this circuit has been designed as part of an implantable vestibular prosthesis to provide inclination signals for bypassing dysfunctional otolith end-organs. The hardware has been implemented in AMS 0.35 mum 2P4M CMOS technology.

CONFERENCE PAPER

Constandinou TG, Georgiou J, 2008, Micro-Optoelectromechanical Tilt Sensor, Journal of Sensors, Vol: 2008, Pages: 1-7, ISSN: 1687-725X

JOURNAL ARTICLE

Constandinou TG, Georgiou J, 2008, Micropower arcsine circuit for tilt processing, ELECTRONICS LETTERS, Vol: 44, Pages: 1336-+, ISSN: 0013-5194

JOURNAL ARTICLE

Constandinou TG, Georgiou J, Andreou CM, 2008, An ultra-low-power micro-optoelectromechanical tilt sensor., Publisher: IEEE, Pages: 3158-3161

CONFERENCE PAPER

Constandinou TG, Georgiou J, Toumazou C, 2008, Micropower front-end interface for differential-capacitive sensor systems, ELECTRONICS LETTERS, Vol: 44, Pages: 470-471, ISSN: 0013-5194

JOURNAL ARTICLE

Constandinou TG, Georgiou J, Toumazou C, 2008, A Fully-Integrated Semicircular Canal Processor for an Implantable Vestibular Prosthesis, IEEE International Conference on Electronics, Circuits and Systems (ICECS), Publisher: IEEE, Pages: 81-84

CONFERENCE PAPER

Constandinou TG, Georgiou J, Toumazou C, 2008, A Partial-Current-Steering Biphasic Stimulation Driver for Vestibular Prostheses, IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS, Vol: 2, Pages: 106-113, ISSN: 1932-4545

JOURNAL ARTICLE

Constandinou TG, Georgiou J, Toumazou C, 2008, A micropower front-end interface for differential-capacitive sensor systems, IEEE International Symposium on Circuits and Systems, Publisher: IEEE, Pages: 2474-+, ISSN: 0271-4302

CONFERENCE PAPER

Constandinou TG, Georgiou J, Toumazou C, 2008, A partial-current-steering biphasic stimulation driver for neural prostheses, IEEE International Symposium on Circuits and Systems, Publisher: IEEE, Pages: 2506-+, ISSN: 0271-4302

CONFERENCE PAPER

Constandinou TG, Georgiou J, Toumazou C, 2008, Towards an Integrated, Fully-Implantable Vestibular Prosthesis for Balance Restoration, Journal of Advances in Science and Technology, Vol: 57, Pages: 210-215

Neuroprosthetics is a relatively new topic but it has already shown its potential. Since the application of this science, it has already significantly improved the quality of life of over 60,000 individuals who previously suffered from severely impaired hearing or total deafness. Today, through use of cochlear implants, children born totally deaf can enjoy going to regular schools and communicating normally. Individuals suffering from dizziness and balance disorders can also benefit from the progress made in cochlear prosthetics. The inner ear's vestibular system provides cues about self-motion and help stabilise vision during movement. Damage to this system can result in dizziness, imbalance, blurred vision and instability in locomotion, a leading cause of death in the elderly. We propose a hybrid CMOS/MEMS platform for bypassing a dysfunctional pathway in individuals that suffer from balance-related disorders. Combining MEMS-based inertia sensing with CMOS-based neural monitoring and processing electronics, this prosthesis aims to deliver a corrective artificial stimulus to the vestibulocochlear (VIII) nerve. We describe a novel system outlining the architectural aspects and implementation methodology used in the design.

JOURNAL ARTICLE

Prodromakis T, Georgiou P, Constandinou TG, Michelakis K, Toumazou Cet al., 2008, Batch Encapsulation Technique for CMOS based Chemical Sensors, IEEE Biomedical Circuits and Systems Conference - Intelligent Biomedical Systems, Publisher: IEEE, Pages: 321-324

CONFERENCE PAPER

Constandinou TG, Georgiou J, Doumanidis CC, Tournazou Cet al., 2007, Towards an Implantable vestibular prosthesis: The surgical challenges, 3rd International IEEE/EMBS Conference on Neural Engineering, Publisher: IEEE, Pages: 40-+

CONFERENCE PAPER

Eftekhar A, Constandinou TG, Triantis IF, Toumazou C, Drakakis EMet al., 2007, Towards a reconfigurable sense-and-stimulate neural interface generating biphasic interleaved stimulus, 3rd International IEEE/EMBS Conference on Neural Engineering, Publisher: IEEE, Pages: 438-+

CONFERENCE PAPER

Georgiou J, Constandinou T, Toumazou C, 2007, A micropower cochlear prosthesis system demonstrator, IEEE International Symposium on Circuits and Systems, Publisher: IEEE, Pages: 1219-1219, ISSN: 0271-4302

CONFERENCE PAPER

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