Summary
I am a Reader within the Computational and Systems Medicine Section of the Department of Surgery and Cancer. My overall research interests lie at the interface between two broad areas:
multivariate data analysis,
and
post-genomic technologies.
More specifically, on the computational side these include, machine learning, bioinformatics, chemometrics, and multivariate statistics, and on the experimental side, the fields of genomics, transcriptomics and metabolomics. I am interested in applying diverse computational and mathematical methods in order to disentangle the mass of information at multiple biological levels generated by the –omics technologies. The ultimate aim is to synthesise the information provided by each of these techniques, thus facilitating a multi-scale understanding of biological systems. This broad aim leads to several themes in my current research:
- Improving information extraction from Nuclear Magnetic Resonance (NMR) spectroscopy & Liquid Chromatography–Mass Spectrometry (LC-MS) metabolic profiles
- Novel methods for predictive modelling of post-genomic data
- Statistical association networks as complex phenotypes in post-genomics
- Statistical integration and visualisation of metabolic profiles with other post-genomic data
- Time series analysis of post-genomic data
Current projects are detailed on my Research page.
teaching
Dr Tim Ebbels introduces the Biomedical Research stream of the MRes in Biomedical Research
Publications
Journals
Chan Q, Loo RL, Ebbels TMD, et al., 2017, Metabolic phenotyping for discovery of urinary biomarkers of diet, xenobiotics and blood pressure in the INTERMAP Study: an overview, Hypertension Research, Vol:40, ISSN:0916-9636, Pages:336-345
Weber RJM, Lawson TN, Salek RM, et al., 2017, Computational tools and workflows in metabolomics: An international survey highlights the opportunity for harmonisation through Galaxy, Metabolomics, Vol:13, ISSN:1573-3882
Blaise BJ, Correia G, Tin A, et al., 2016, Power Analysis and Sample Size Determination in Metabolic Phenotyping, Analytical Chemistry, Vol:88, ISSN:0003-2700, Pages:5179-5188
David R, Ebbels T, Gooderham N, 2016, Synergistic and Antagonistic Mutation Responses of Human MCL-5 Cells to Mixtures of Benzo[a]pyrene and 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]pyridine: Dose-Related Variation in the Joint Effects of Common Dietary Carcinogens, Environmental Health Perspectives, Vol:124, ISSN:0091-6765, Pages:88-96
Conference
Griep LMO, Chekmeneva E, Stamler J, et al., 2016, Urinary hippurate and proline betaine relative to fruit intake, blood pressure, and body mass index, CAMBRIDGE UNIV PRESS, Pages:E178-E178, ISSN:0029-6651