Imperial College London
Portrait Picture

Tom Ellis

Faculty of Engineering, Department of Bioengineering

Professor of Synthetic Genome Engineering
 
 
 
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Contact

 

+44 (0)20 7594 7615t.ellis Website CV

 
 
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Location

 

704Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gilbert:2021:10.1038/s41563-020-00857-5,
author = {Gilbert, C and Tang, T-C and Ott, W and Dorr, B and Shaw, W and Sun, G and Lu, T and Ellis, T},
doi = {10.1038/s41563-020-00857-5},
journal = {Nature Materials},
pages = {691--700},
title = {Living materials with programmable functionalities grown from engineered microbial co-cultures},
url = {http://dx.doi.org/10.1038/s41563-020-00857-5},
volume = {20},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Biological systems assemble living materials that are autonomously patterned, can self-repair and can sense and respond to their environment. The field of engineered living materials aims to create novel materials with properties similar to those of natural biomaterials using genetically-engineered organisms. Here we describe an approach to fabricate functional bacterial cellulose-based living materials using a stable co-culture of Saccharomyces cerevisiae yeast and bacterial cellulose-producing Komagataeibacter rhaeticus bacteria. Yeast strains can be engineered to secrete enzymes into bacterial cellulose, generating autonomously grown catalytic materials and enabling DNA-encoded modification of bacterial cellulose bulk properties. Alternatively, engineered yeast can be incorporated within the growing cellulose matrix, creating living materials that can sense and respond to chemical and optical stimuli. This symbiotic culture of bacteria and yeast is a flexible platform for the production of bacterial cellulosed-based engineered living materials with potential applications in biosensing and biocatalysis.
AU  - Gilbert,C
AU  - Tang,T-C
AU  - Ott,W
AU  - Dorr,B
AU  - Shaw,W
AU  - Sun,G
AU  - Lu,T
AU  - Ellis,T
DO  - 10.1038/s41563-020-00857-5
EP  - 700
PY  - 2021///
SN  - 1476-1122
SP  - 691
TI  - Living materials with programmable functionalities grown from engineered microbial co-cultures
T2  - Nature Materials
UR  - http://dx.doi.org/10.1038/s41563-020-00857-5
UR  - https://www.nature.com/articles/s41563-020-00857-5
UR  - http://hdl.handle.net/10044/1/84824
VL  - 20
ER  -
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