381 results found
Chai W, Zhang Y, Mauri L, et al., 2018, Assignment by Negative-Ion Electrospray Tandem Mass Spectrometry of the Tetrasaccharide Backbones of Monosialylated Glycans Released from Bovine Brain Gangliosides, JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol: 29, Pages: 1308-1318, ISSN: 1044-0305
Lenman A, Liaci AM, Liu Y, et al., 2018, Polysialic acid is a cellular receptor for human adenovirus 52, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 115, Pages: E4264-E4273, ISSN: 0027-8424
Li Z, Feizi T, 2018, The neoglycolipid (NGL) technology-based microarrays and future prospects., FEBS Lett
The neoglycolipid (NGL) technology is the basis of a state-of-the-art oligosaccharide microarray system, which we offer for screening analyses to the broad scientific community. We review here the sequential development of the technology and its power in pinpointing and isolating naturally occurring ligands for glycan-binding proteins (GBPs) within glycan populations. We highlight our Designer Array approach and Beam Search Array approach for generating natural glycome arrays to identify novel ligands of biological relevance. These two microarray approaches have been applied for assignments of ligands or antigens on glucan polysaccharides for effector proteins of the immune system (Dectin-1, DC-SIGN and DC-SIGNR) and carbohydrate-binding modules (CBMs) on bacterial hydrolases. We also discuss here the more recent applications to elucidate the structure of a prostate cancer- associated antigen F77 and identify ligands for adhesins of two rotaviruses, P and P, expressed on an epithelial mucin glycoprotein.
Li Z, Gao C, Zhang Y, et al., 2018, O-Glycome Beam Search Arrays for Carbohydrate Ligand Discovery, MOLECULAR & CELLULAR PROTEOMICS, Vol: 17, Pages: 135-147, ISSN: 1535-9476
Liu Y, Palma AS, Ten F, et al., 2018, Insights Into Glucan Polysaccharide Recognition Using Glucooligosaccharide Microarrays With Oxime-Linked Neoglycolipid Probes, Editors: Imperiali, Publisher: ELSEVIER ACADEMIC PRESS INC, Pages: 139-167
Stappers MHT, Clark AE, Aimanianda V, et al., 2018, Recognition of DHN-melanin by the C-type lectin, MelLec, is required for protective immunity to Aspergillus fumigatus, Publisher: OXFORD UNIV PRESS, Pages: S156-S156, ISSN: 1369-3786
Stappers MHT, Clark AE, Aimanianda V, et al., 2018, Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus, NATURE, Vol: 555, Pages: 382-+, ISSN: 0028-0836
Akune Y, Arpinar S, Stoll M, et al., 2017, New software for glycan array for data processing, storage and presentation, Annual Meeting of the Society-for-Glycobiology, Publisher: OXFORD UNIV PRESS INC, Pages: 1204-1204, ISSN: 0959-6658
Catera R, Liu Y, Gao C, et al., 2017, Binding of CLL Subset 4 B Cell Receptor Immunoglobulins to Viable Human Memory B Lymphocytes Requires a Distinctive IGKV Somatic Mutation, MOLECULAR MEDICINE, Vol: 23, Pages: 1-12, ISSN: 1076-1551
Liu Y, Catera R, Gao C, et al., 2017, The (auto)antigen specificities of B cell receptor immunoglobulins from CLL stereotyped subset 4 are positively and negatively selected by structural elements introduced by somatic mutation and isotype class switching, Publisher: TAYLOR & FRANCIS LTD, Pages: 80-81, ISSN: 1042-8194
Liu Y, McBride R, Stoll M, et al., 2017, The minimum information required for a glycomics experiment (MIRAGE) project: improving the standards for reporting glycan microarray-based data, GLYCOBIOLOGY, Vol: 27, Pages: 280-284, ISSN: 0959-6658
Panagos C, Moss C, Bavington C, et al., 2017, Analysis of the 3D structure of fucosylated chondroitin sulfate from H. forskali and its interaction with selectins, 254th National Meeting and Exposition of the American-Chemical-Society (ACS) on Chemistry's Impact on the Global Economy, Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727
Bartels MF, Winterhalter PR, Yu J, et al., 2016, Protein O-Mannosylation in the Murine Brain: Occurrence of Mono-O-Mannosyl Glycans and Identification of New Substrates, PLOS ONE, Vol: 11, ISSN: 1932-6203
Cecílio NT, Carvalho FC, Liu Y, et al., 2016, Yeast expressed ArtinM shares structure, carbohydrate recognition, and biological effects with native ArtinM., Int J Biol Macromol, Vol: 82, Pages: 22-30
Recent advances in glycobiology have revealed the essential role of lectins in deciphering the glycocodes at the cell surface to generate important biological signaling responses. ArtinM, a d-mannose-binding lectin isolated from the seeds of jackfruit (Artocarpus heterophyllus), is composed of 16 kDa subunits that are associated to form a homotetramer. Native ArtinM (n-ArtinM) exerts immunomodulatory and regenerative effects, but the potential pharmaceutical applicability of the lectin is highly limited by the fact that its production is expensive, laborious, and impossible to be scaled up. This led us to characterize a recombinant form of the lectin obtained by expression in Saccharomyces cerevisiae (y-ArtinM). In the present study, we demonstrated that y-ArtinM is similar to n-ArtinM in subunit arrangement, oligomerization and carbohydrate binding specificity. We showed that y-ArtinM can exert n-ArtinM biological activities such as erythrocyte agglutination, stimulation of neutrophil migration and degranulation, mast cell degranulation, and induction of interleukin-12 and interleukin-10 production by macrophages. In summary, the expression of ArtinM in yeast resulted in successful production of an active, recombinant form of ArtinM that is potentially useful for pharmaceutical application.
Correia VG, Bras JLA, Liu Y, et al., 2016, An integrative strategy to decipher glycan recognition in the human gut microbiome, Annual Meeting of the Society-for-Glycobiology, Publisher: OXFORD UNIV PRESS INC, Pages: 1398-1399, ISSN: 0959-6658
Liu Y, Ramelot TA, Huang P, et al., 2016, Glycan Specificity of P Rotavirus and Comparison with Those of Related P Genotypes, JOURNAL OF VIROLOGY, Vol: 90, Pages: 9983-9996, ISSN: 0022-538X
Mulloy B, Wu N, Gyarn-Quast F, et al., 2016, Abnormally High Content of Free Glucosamine Residues Identified in a Preparation of Commercially Available Porcine Intestinal Heparan Sulfate, ANALYTICAL CHEMISTRY, Vol: 88, Pages: 6648-6652, ISSN: 0003-2700
Parker L, Wharton SA, Martin SR, et al., 2016, Effects of egg-adaptation on receptor-binding and antigenic properties of recent influenza A (H3N2) vaccine viruses, JOURNAL OF GENERAL VIROLOGY, Vol: 97, Pages: 1333-1344, ISSN: 0022-1317
Struwe WB, Agravat S, Aoki-Kinoshita KF, et al., 2016, The minimum information required for a glycomics experiment (MIRAGE) project: sample preparation guidelines for reliable reporting of glycomics datasets, GLYCOBIOLOGY, Vol: 26, Pages: 907-910, ISSN: 0959-6658
Zhang H, Palma AS, Zhang Y, et al., 2016, Generation and characterization of beta 1,2-gluco-oligosaccharide probes from Brucella abortus cyclic beta-glucan and their recognition by C-type lectins of the immune system, GLYCOBIOLOGY, Vol: 26, Pages: 1086-1096, ISSN: 0959-6658
Feizi TEN, Haltiwanger RS, 2015, Editorial overview: Carbohydrate-protein interactions and glycosylation: Glycan synthesis and recognition: finding the perfect partner in a sugar-coated life., Curr Opin Struct Biol, Vol: 34, Pages: vii-ix
Oligosaccharides expressed on the surface of cells and in biological fluids as glycoproteins, glycolipids, proteoglycans and polysaccharides can be recognized by partner proteins, and these interactions have been shown to mediate fundamental biological events such as occur in the immune system, signal transduction, development and cancer metastasis. The specificities of these partner proteins (lectins) for their glycan ligands are determined by factors such as glycan composition, shape and density of expression and the involvement of the aglycone moiety as part of the recognition motif. There is increasing knowledge on the mechanisms of these interactions as new secondary binding sites continue to be elucidated adding to the functional awareness of sugar-binding proteins. This issue focuses on recent advances in understanding how C-type lectins in the immune system work, how novel motifs involving asymmetric glycan branch recognition and protein-protein interactions influence critical biological functions including signal transduction and bactericidal pore formation, recent studies on novel glycan-binding proteins produced by bacteriophage, analysis of the interactions between heparin/heparan sulphate and their binding proteins, and recent findings on the molecular interactions between chondroitin-dermatan sulphate and various bioactive protein components. We conclude with a review on a recent fascinating class of processive enzymes responsible for synthesis of high-molecular weight extracellular polysaccharides such as hyaluronic acid, chitin and alginate.
Gao C, Zhang Y, Liu Y, et al., 2015, Negative-Jon Electrospray Tandem Mass Spectrometry and Microarray Analyses of Developmentally Regulated Antigens Based on Type 1 and Type 2 Backbone Sequences, ANALYTICAL CHEMISTRY, Vol: 87, Pages: 11871-11878, ISSN: 0003-2700
Gyapon-Quast F, Chai W, Liu Y, et al., 2015, Complement factor H-related protein 5 binding to heparan sulphate increases factor H de-regulation in vitro, 15th European Meeting on Complement in Human Disease (EMCHD), Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: 141-141, ISSN: 0161-5890
Hanashima S, Goetze S, Liu Y, et al., 2015, Defining the Interaction of Human Soluble Lectin ZG16p and Mycobacterial Phosphatidylinositol Mannosides, CHEMBIOCHEM, Vol: 16, Pages: 1502-1511, ISSN: 1439-4227
Hirose H, Tamai H, Gao C, et al., 2015, Total syntheses of disulphated glycosphingolipid SB1a and the related monosulphated SM1a, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol: 13, Pages: 11105-11117, ISSN: 1477-0520
Kakugawa S, Langton PF, Zebisch M, et al., 2015, Notum deacylates Wnt proteins to suppress signalling activity, NATURE, Vol: 519, Pages: 187-+, ISSN: 0028-0836
Lenman A, Liaci AM, Liu Y, et al., 2015, Human Adenovirus 52 Uses Sialic Acid-containing Glycoproteins and the Coxsackie and Adenovirus Receptor for Binding to Target Cells, PLOS PATHOGENS, Vol: 11, ISSN: 1553-7366
Liu Y, Cecílio NT, Carvalho FC, et al., 2015, Glycan microarray analysis of the carbohydrate-recognition specificity of native and recombinant forms of the lectin ArtinM., Data Brief, Vol: 5, Pages: 1035-1047, ISSN: 2352-3409
This article contains data related to the researc.h article entitled "Yeast-derived ArtinM shares structure, carbohydrate recognition, and biological effects with native ArtinM" by Cecílio et al. (2015) . ArtinM, a D-mannose-binding lectin isolated from the seeds of Artocarpus heterophyllus, exerts immunomodulatory and regenerative activities through its Carbohydrate Recognition Domain (CRD) (Souza et al., 2013; Mariano et al., 2014 , ). The limited availability of the native lectin (n-ArtinM) led us to characterize a recombinant form of the protein, obtained by expression in Saccharomyces cerevisiae (y-ArtinM). We compared the carbohydrate-binding specificities of y-ArtinM and n-ArtinM by analyzing the binding of biotinylated preparations of the two lectin forms using a neoglycolipid (NGL)-based glycan microarray. Data showed that y-ArtinM mirrored the specificity exhibited by n-ArtinM.
Palma AS, Liu Y, Zhang H, et al., 2015, Unravelling Glucan Recognition Systems by Glycome Microarrays Using the Designer Approach and Mass Spectrometry, MOLECULAR & CELLULAR PROTEOMICS, Vol: 14, Pages: 974-988, ISSN: 1535-9476
Silva L, Childs RA, Palma AS, et al., 2015, Influence of carrier lipid composition on glycan recognition in NGL-based microarrays, Annual Meeting of the Society-for-Glycobiology on Glycobiology - Accelerating Impact across the Biomedical Sciences, Publisher: OXFORD UNIV PRESS INC, Pages: 1260-1260, ISSN: 0959-6658
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