Imperial College London

ProfessorTenFeizi

Faculty of MedicineDepartment of Surgery & Cancer

Professor and Director of the Glycosciences Laboratory
 
 
 
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Contact

 

+44 (0)20 7594 7207t.feizi

 
 
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Location

 

E518Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

381 results found

Chai W, Zhang Y, Mauri L, Ciampa MG, Mulloy B, Sonnino S, Feizi Tet al., 2018, Assignment by Negative-Ion Electrospray Tandem Mass Spectrometry of the Tetrasaccharide Backbones of Monosialylated Glycans Released from Bovine Brain Gangliosides, JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol: 29, Pages: 1308-1318, ISSN: 1044-0305

JOURNAL ARTICLE

Lenman A, Liaci AM, Liu Y, Frangsmyr L, Frank M, Blaum BS, Chai W, Podgorski II, Harrach B, Benko M, Feizi T, Stehle T, Arnberg Net al., 2018, Polysialic acid is a cellular receptor for human adenovirus 52, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 115, Pages: E4264-E4273, ISSN: 0027-8424

JOURNAL ARTICLE

Li Z, Feizi T, 2018, The neoglycolipid (NGL) technology-based microarrays and future prospects., FEBS Lett

The neoglycolipid (NGL) technology is the basis of a state-of-the-art oligosaccharide microarray system, which we offer for screening analyses to the broad scientific community. We review here the sequential development of the technology and its power in pinpointing and isolating naturally occurring ligands for glycan-binding proteins (GBPs) within glycan populations. We highlight our Designer Array approach and Beam Search Array approach for generating natural glycome arrays to identify novel ligands of biological relevance. These two microarray approaches have been applied for assignments of ligands or antigens on glucan polysaccharides for effector proteins of the immune system (Dectin-1, DC-SIGN and DC-SIGNR) and carbohydrate-binding modules (CBMs) on bacterial hydrolases. We also discuss here the more recent applications to elucidate the structure of a prostate cancer- associated antigen F77 and identify ligands for adhesins of two rotaviruses, P[10] and P[19], expressed on an epithelial mucin glycoprotein.

JOURNAL ARTICLE

Li Z, Gao C, Zhang Y, Palma AS, Childs RA, Silva LM, Liu Y, Jiang X, Liu Y, Chai W, Feizi Tet al., 2018, O-Glycome Beam Search Arrays for Carbohydrate Ligand Discovery, MOLECULAR & CELLULAR PROTEOMICS, Vol: 17, Pages: 135-147, ISSN: 1535-9476

JOURNAL ARTICLE

Liu Y, Palma AS, Ten F, Chai Wet al., 2018, Insights Into Glucan Polysaccharide Recognition Using Glucooligosaccharide Microarrays With Oxime-Linked Neoglycolipid Probes, Editors: Imperiali, Publisher: ELSEVIER ACADEMIC PRESS INC, Pages: 139-167

BOOK CHAPTER

Stappers MHT, Clark AE, Aimanianda V, Bidula S, Reid DM, Asamaphan P, Hardison SE, Dambuza IM, Valsecchi I, Kerscher B, Plato A, Wallace CA, Yuecel R, Hebecker B, Sousa MDGT, Cunha C, Liu Y, Feizi T, Brakhage AA, Kwon-Chung KJ, Gow NAR, Zanda M, Piras M, Zanato C, Jaeger M, Netea MG, Van de Veerdonk FL, Lacerda JF, Campos A, Carvalho A, Willment JA, Latge JP, Brown GDet al., 2018, Recognition of DHN-melanin by the C-type lectin, MelLec, is required for protective immunity to Aspergillus fumigatus, Publisher: OXFORD UNIV PRESS, Pages: S156-S156, ISSN: 1369-3786

CONFERENCE PAPER

Stappers MHT, Clark AE, Aimanianda V, Bidula S, Reid DM, Asamaphan P, Hardison SE, Dambuza IM, Valsecchi I, Kerscher B, Plato A, Wallace CA, Yuecel R, Hebecker B, Teixeira Sousa MDG, Cunha C, Liu Y, Feizi T, Brakhage AA, Kwon-Chung KJ, Gow NAR, Zanda M, Piras M, Zanato C, Jaeger M, Netea MG, de Veerdonk FLV, Lacerda JF, Campos A, Carvalho A, Willment JA, Latge J-P, Brown GDet al., 2018, Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus, NATURE, Vol: 555, Pages: 382-+, ISSN: 0028-0836

JOURNAL ARTICLE

Akune Y, Arpinar S, Stoll M, Silva LM, Palma AS, Liu Y, Ranzinger R, Feizi Tet al., 2017, New software for glycan array for data processing, storage and presentation, Annual Meeting of the Society-for-Glycobiology, Publisher: OXFORD UNIV PRESS INC, Pages: 1204-1204, ISSN: 0959-6658

CONFERENCE PAPER

Catera R, Liu Y, Gao C, Yan X-J, Magli A, Allen SL, Kolitz JE, Rai KR, Chu CC, Feizi T, Stamatopoulos K, Chiorazzi Net al., 2017, Binding of CLL Subset 4 B Cell Receptor Immunoglobulins to Viable Human Memory B Lymphocytes Requires a Distinctive IGKV Somatic Mutation, MOLECULAR MEDICINE, Vol: 23, Pages: 1-12, ISSN: 1076-1551

JOURNAL ARTICLE

Liu Y, Catera R, Gao C, Yan J, Magli A, Allen SL, Rai K, Chu CC, Stamatopoulos K, Chiorazzi N, Kolitz JE, Feizi Tet al., 2017, The (auto)antigen specificities of B cell receptor immunoglobulins from CLL stereotyped subset 4 are positively and negatively selected by structural elements introduced by somatic mutation and isotype class switching, Publisher: TAYLOR & FRANCIS LTD, Pages: 80-81, ISSN: 1042-8194

CONFERENCE PAPER

Liu Y, McBride R, Stoll M, Palma AS, Silva L, Agravat S, Aoki-Kinoshita KF, Campbell MP, Costello CE, Dell A, Haslam SM, Karlsson NG, Khoo K-H, Kolarich D, Novotny MV, Packer NH, Ranzinger R, Rapp E, Rudd PM, Struwe WB, Tiemeyer M, Wells L, York WS, Zaia J, Kettner C, Paulson JC, Feizi T, Smith DFet al., 2017, The minimum information required for a glycomics experiment (MIRAGE) project: improving the standards for reporting glycan microarray-based data, GLYCOBIOLOGY, Vol: 27, Pages: 280-284, ISSN: 0959-6658

JOURNAL ARTICLE

Panagos C, Moss C, Bavington C, Mulloy B, Feizi T, Chai W, Woods R, Uhrin Det al., 2017, Analysis of the 3D structure of fucosylated chondroitin sulfate from H. forskali and its interaction with selectins, 254th National Meeting and Exposition of the American-Chemical-Society (ACS) on Chemistry's Impact on the Global Economy, Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727

CONFERENCE PAPER

Bartels MF, Winterhalter PR, Yu J, Liu Y, Lommel M, Moehrlen F, Hu H, Feizi T, Westerlind U, Ruppert T, Strahl Set al., 2016, Protein O-Mannosylation in the Murine Brain: Occurrence of Mono-O-Mannosyl Glycans and Identification of New Substrates, PLOS ONE, Vol: 11, ISSN: 1932-6203

JOURNAL ARTICLE

Cecílio NT, Carvalho FC, Liu Y, Moncrieffe M, Buranello PADA, Zorzetto-Fernandes AL, Luche DD, Hanna ES, Soares SG, Feizi T, Gay NJ, Goldman MHS, Roque-Barreira MCet al., 2016, Yeast expressed ArtinM shares structure, carbohydrate recognition, and biological effects with native ArtinM., Int J Biol Macromol, Vol: 82, Pages: 22-30

Recent advances in glycobiology have revealed the essential role of lectins in deciphering the glycocodes at the cell surface to generate important biological signaling responses. ArtinM, a d-mannose-binding lectin isolated from the seeds of jackfruit (Artocarpus heterophyllus), is composed of 16 kDa subunits that are associated to form a homotetramer. Native ArtinM (n-ArtinM) exerts immunomodulatory and regenerative effects, but the potential pharmaceutical applicability of the lectin is highly limited by the fact that its production is expensive, laborious, and impossible to be scaled up. This led us to characterize a recombinant form of the lectin obtained by expression in Saccharomyces cerevisiae (y-ArtinM). In the present study, we demonstrated that y-ArtinM is similar to n-ArtinM in subunit arrangement, oligomerization and carbohydrate binding specificity. We showed that y-ArtinM can exert n-ArtinM biological activities such as erythrocyte agglutination, stimulation of neutrophil migration and degranulation, mast cell degranulation, and induction of interleukin-12 and interleukin-10 production by macrophages. In summary, the expression of ArtinM in yeast resulted in successful production of an active, recombinant form of ArtinM that is potentially useful for pharmaceutical application.

JOURNAL ARTICLE

Correia VG, Bras JLA, Liu Y, Silva L, Zhang Y, Pinheiro BA, Romao MJ, Carvalho AL, Chai W, Fontes CMGA, Feizi T, Palma ASet al., 2016, An integrative strategy to decipher glycan recognition in the human gut microbiome, Annual Meeting of the Society-for-Glycobiology, Publisher: OXFORD UNIV PRESS INC, Pages: 1398-1399, ISSN: 0959-6658

CONFERENCE PAPER

Liu Y, Ramelot TA, Huang P, Liu Y, Li Z, Feizi T, Zhong W, Wu F-T, Tan M, Kennedy MA, Jiang Xet al., 2016, Glycan Specificity of P[19] Rotavirus and Comparison with Those of Related P Genotypes, JOURNAL OF VIROLOGY, Vol: 90, Pages: 9983-9996, ISSN: 0022-538X

JOURNAL ARTICLE

Mulloy B, Wu N, Gyarn-Quast F, Lin L, Zhang F, Pickering MC, Linhardt RJ, Feizi T, Chai Wet al., 2016, Abnormally High Content of Free Glucosamine Residues Identified in a Preparation of Commercially Available Porcine Intestinal Heparan Sulfate, ANALYTICAL CHEMISTRY, Vol: 88, Pages: 6648-6652, ISSN: 0003-2700

JOURNAL ARTICLE

Parker L, Wharton SA, Martin SR, Cross K, Lin Y, Liu Y, Feizi T, Daniels RS, McCauley JWet al., 2016, Effects of egg-adaptation on receptor-binding and antigenic properties of recent influenza A (H3N2) vaccine viruses, JOURNAL OF GENERAL VIROLOGY, Vol: 97, Pages: 1333-1344, ISSN: 0022-1317

JOURNAL ARTICLE

Struwe WB, Agravat S, Aoki-Kinoshita KF, Campbell MP, Costello CE, Dell A, Feizi T, Haslam SM, Karlsson NG, Khoo K-H, Kolarich D, Liu Y, McBride R, Novotny MV, Packer NH, Paulson JC, Rapp E, Ranzinger R, Rudd PM, Smith DF, Tiemeyer M, Wells L, York WS, Zaia J, Kettner Cet al., 2016, The minimum information required for a glycomics experiment (MIRAGE) project: sample preparation guidelines for reliable reporting of glycomics datasets, GLYCOBIOLOGY, Vol: 26, Pages: 907-910, ISSN: 0959-6658

JOURNAL ARTICLE

Zhang H, Palma AS, Zhang Y, Childs RA, Liu Y, Mitchell DA, Guidolin LS, Weigel W, Mulloy B, Ciocchini AE, Feizi T, Chai Wet al., 2016, Generation and characterization of beta 1,2-gluco-oligosaccharide probes from Brucella abortus cyclic beta-glucan and their recognition by C-type lectins of the immune system, GLYCOBIOLOGY, Vol: 26, Pages: 1086-1096, ISSN: 0959-6658

JOURNAL ARTICLE

Feizi TEN, Haltiwanger RS, 2015, Editorial overview: Carbohydrate-protein interactions and glycosylation: Glycan synthesis and recognition: finding the perfect partner in a sugar-coated life., Curr Opin Struct Biol, Vol: 34, Pages: vii-ix

Oligosaccharides expressed on the surface of cells and in biological fluids as glycoproteins, glycolipids, proteoglycans and polysaccharides can be recognized by partner proteins, and these interactions have been shown to mediate fundamental biological events such as occur in the immune system, signal transduction, development and cancer metastasis. The specificities of these partner proteins (lectins) for their glycan ligands are determined by factors such as glycan composition, shape and density of expression and the involvement of the aglycone moiety as part of the recognition motif. There is increasing knowledge on the mechanisms of these interactions as new secondary binding sites continue to be elucidated adding to the functional awareness of sugar-binding proteins. This issue focuses on recent advances in understanding how C-type lectins in the immune system work, how novel motifs involving asymmetric glycan branch recognition and protein-protein interactions influence critical biological functions including signal transduction and bactericidal pore formation, recent studies on novel glycan-binding proteins produced by bacteriophage, analysis of the interactions between heparin/heparan sulphate and their binding proteins, and recent findings on the molecular interactions between chondroitin-dermatan sulphate and various bioactive protein components. We conclude with a review on a recent fascinating class of processive enzymes responsible for synthesis of high-molecular weight extracellular polysaccharides such as hyaluronic acid, chitin and alginate.

JOURNAL ARTICLE

Gao C, Zhang Y, Liu Y, Ten F, Chai Wet al., 2015, Negative-Jon Electrospray Tandem Mass Spectrometry and Microarray Analyses of Developmentally Regulated Antigens Based on Type 1 and Type 2 Backbone Sequences, ANALYTICAL CHEMISTRY, Vol: 87, Pages: 11871-11878, ISSN: 0003-2700

JOURNAL ARTICLE

Gyapon-Quast F, Chai W, Liu Y, Pickering MC, Feizi Tet al., 2015, Complement factor H-related protein 5 binding to heparan sulphate increases factor H de-regulation in vitro, 15th European Meeting on Complement in Human Disease (EMCHD), Publisher: PERGAMON-ELSEVIER SCIENCE LTD, Pages: 141-141, ISSN: 0161-5890

CONFERENCE PAPER

Hanashima S, Goetze S, Liu Y, Ikeda A, Kojima-Aikawa K, Taniguchi N, Silva DV, Feizi T, Seeberger PH, Yamaguchi Yet al., 2015, Defining the Interaction of Human Soluble Lectin ZG16p and Mycobacterial Phosphatidylinositol Mannosides, CHEMBIOCHEM, Vol: 16, Pages: 1502-1511, ISSN: 1439-4227

JOURNAL ARTICLE

Hirose H, Tamai H, Gao C, Imamura A, Ando H, Ishida H, Feizi T, Kiso Met al., 2015, Total syntheses of disulphated glycosphingolipid SB1a and the related monosulphated SM1a, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol: 13, Pages: 11105-11117, ISSN: 1477-0520

JOURNAL ARTICLE

Kakugawa S, Langton PF, Zebisch M, Howell SA, Chang T-H, Liu Y, Ten F, Bineva G, O'Reilly N, Snijders AP, Jones EY, Vincent J-Pet al., 2015, Notum deacylates Wnt proteins to suppress signalling activity, NATURE, Vol: 519, Pages: 187-+, ISSN: 0028-0836

JOURNAL ARTICLE

Lenman A, Liaci AM, Liu Y, Ardahl C, Rajan A, Nilsson E, Bradford W, Kaeshammer L, Jones MS, Frangsmyr L, Feizi T, Stehle T, Arnberg Net al., 2015, Human Adenovirus 52 Uses Sialic Acid-containing Glycoproteins and the Coxsackie and Adenovirus Receptor for Binding to Target Cells, PLOS PATHOGENS, Vol: 11, ISSN: 1553-7366

JOURNAL ARTICLE

Liu Y, Cecílio NT, Carvalho FC, Roque-Barreira MC, Feizi Tet al., 2015, Glycan microarray analysis of the carbohydrate-recognition specificity of native and recombinant forms of the lectin ArtinM., Data Brief, Vol: 5, Pages: 1035-1047, ISSN: 2352-3409

This article contains data related to the researc.h article entitled "Yeast-derived ArtinM shares structure, carbohydrate recognition, and biological effects with native ArtinM" by Cecílio et al. (2015) [1]. ArtinM, a D-mannose-binding lectin isolated from the seeds of Artocarpus heterophyllus, exerts immunomodulatory and regenerative activities through its Carbohydrate Recognition Domain (CRD) (Souza et al., 2013; Mariano et al., 2014 [2], [3]). The limited availability of the native lectin (n-ArtinM) led us to characterize a recombinant form of the protein, obtained by expression in Saccharomyces cerevisiae (y-ArtinM). We compared the carbohydrate-binding specificities of y-ArtinM and n-ArtinM by analyzing the binding of biotinylated preparations of the two lectin forms using a neoglycolipid (NGL)-based glycan microarray. Data showed that y-ArtinM mirrored the specificity exhibited by n-ArtinM.

JOURNAL ARTICLE

Palma AS, Liu Y, Zhang H, Zhang Y, McCleary BV, Yu G, Huang Q, Guidolin LS, Ciocchini AE, Torosantucci A, Wang D, Carvalho AL, Fontes CMGA, Mulloy B, Childs RA, Feizi T, Chai Wet al., 2015, Unravelling Glucan Recognition Systems by Glycome Microarrays Using the Designer Approach and Mass Spectrometry, MOLECULAR & CELLULAR PROTEOMICS, Vol: 14, Pages: 974-988, ISSN: 1535-9476

JOURNAL ARTICLE

Silva L, Childs RA, Palma AS, Chai W, Feizi T, Liu Yet al., 2015, Influence of carrier lipid composition on glycan recognition in NGL-based microarrays, Annual Meeting of the Society-for-Glycobiology on Glycobiology - Accelerating Impact across the Biomedical Sciences, Publisher: OXFORD UNIV PRESS INC, Pages: 1260-1260, ISSN: 0959-6658

CONFERENCE PAPER

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