Imperial College London

Dr Tini Garske

Faculty of MedicineSchool of Public Health

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 3247t.garske

 
 
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Location

 

G24Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Watson:10.7554/elife.40339,
author = {Watson, OJ and Verity, R and Ghani, AC and Garske, T and Cunningham, J and Tshefu, A and Mwandagalirwa, MK and Meshnick, SR and Parr, JB and Slater, HC},
doi = {10.7554/elife.40339},
journal = {eLife},
title = {Impact of seasonal variations in Plasmodium falciparum malaria transmission on the surveillance of pfhrp2 gene deletions},
url = {http://dx.doi.org/10.7554/elife.40339},
volume = {8},
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Ten countries have reported pfhrp2/pfhrp3 gene deletions since the first observation of pfhrp2-deleted parasites in 2012. In a previous study (Watson et al., 2017) we characterised the drivers selecting for pfhrp2/3 deletions, and mapped the regions in Africa with the greatest selection pressure. In February 2018, the World Health Organization issued guidance on investigating suspected false-negative rapid diagnostic tests (RDTs) due to pfhrp2/3 deletions. However, no guidance is provided regarding the timing of investigations. Failure to consider seasonal variation could cause premature decisions to switch to alternative RDTs. In response, we have extended our methods and predict that the prevalence of false-negative RDTs due to pfhrp2/3 deletions is highest when sampling from younger individuals during the beginning of the rainy season. We conclude by producing a map of the regions impacted by seasonal fluctuations in pfhrp2/3 deletions and a database identifying optimum sampling intervals to support malaria control programmes.
AU - Watson,OJ
AU - Verity,R
AU - Ghani,AC
AU - Garske,T
AU - Cunningham,J
AU - Tshefu,A
AU - Mwandagalirwa,MK
AU - Meshnick,SR
AU - Parr,JB
AU - Slater,HC
DO - 10.7554/elife.40339
SN - 2050-084X
TI - Impact of seasonal variations in Plasmodium falciparum malaria transmission on the surveillance of pfhrp2 gene deletions
T2 - eLife
UR - http://dx.doi.org/10.7554/elife.40339
UR - http://hdl.handle.net/10044/1/69484
VL - 8
ER -