Imperial College London

Dr Tini Garske

Faculty of MedicineSchool of Public Health

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 3247t.garske

 
 
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Location

 

G24Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lessler:2016:aje/kwv452,
author = {Lessler, J and Salje, H and van, Kerkhove M and Collins, C},
doi = {aje/kwv452},
journal = {American Journal of Epidemiology},
pages = {657--663},
title = {Estimating the Severity and Subclinical Burden of Middle East Respiratory Syndrome Coronavirus Infection in the Kingdom of Saudi Arabia},
url = {http://dx.doi.org/10.1093/aje/kwv452},
volume = {183},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Not all persons infected with Middle East respiratory syndrome coronavirus (MERS-CoV) develop severe symptoms, which likely leads to an underestimation of the number of people infected and an overestimation of the severity. To estimate the number of MERS-CoV infections that have occurred in the Kingdom of Saudi Arabia, we applied a statistical model to a line list describing 721 MERS-CoV infections detected between June 7, 2012, and July 25, 2014. We estimated that 1,528 (95% confidence interval (CI): 1,327, 1,883) MERS-CoV infections occurred in this interval, which is 2.1 (95% CI: 1.8, 2.6) times the number reported. The probability of developing symptoms ranged from 11% (95% CI: 4, 25) in persons under 10 years of age to 88% (95% CI: 72, 97) in those 70 years of age or older. An estimated 22% (95% CI: 18, 25) of those infected with MERS-CoV died. MERS-CoV is deadly, but this work shows that its clinical severity differs markedly between groups and that many cases likely go undiagnosed.
AU - Lessler,J
AU - Salje,H
AU - van,Kerkhove M
AU - Collins,C
DO - aje/kwv452
EP - 663
PY - 2016///
SN - 1476-6256
SP - 657
TI - Estimating the Severity and Subclinical Burden of Middle East Respiratory Syndrome Coronavirus Infection in the Kingdom of Saudi Arabia
T2 - American Journal of Epidemiology
UR - http://dx.doi.org/10.1093/aje/kwv452
VL - 183
ER -