Imperial College London

Dr Tini Garske

Faculty of MedicineSchool of Public Health

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 3247t.garske

 
 
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Location

 

G24Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jean:2016:10.4269/ajtmh.16-0401,
author = {Jean, K and Donnelly, C and Ferguson, N and Garske, T},
doi = {10.4269/ajtmh.16-0401},
journal = {American Journal of Tropical Medicine and Hygiene},
pages = {1435--1439},
title = {A meta-analysis of serological response associated with yellow fever vaccination},
url = {http://dx.doi.org/10.4269/ajtmh.16-0401},
volume = {95},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Despite previous evidence of high level of efficacy, no synthetic metric of yellow fever (YF) vaccine efficacy is currently available. Based on the studies identified in a recent systematic review, we conducted a random-effects meta-analysis of the serological response associated with YF vaccination. Eleven studies conducted between 1965 and 2011 representing 4,868 individual observations were included in the meta-analysis. The pooled estimate of serological response was 97.5% (95% confidence interval [CI] = 82.9–99.7%). There was evidence of between-study heterogeneity (I2 = 89.1%), but this heterogeneity did not appear to be related to study size, study design, seroconversion measurement, or definition. Pooled estimates were significantly higher (P & 0.0001) among studies conducted in nonendemic settings (98.9%, 95% CI = 98.2–99.4%) than among those conducted in endemic settings (94.2%, 95% CI = 83.8–98.1%). These results provide background information against which to evaluate the efficacy of fractional doses of YF vaccine that may be used in outbreak situations.
AU - Jean,K
AU - Donnelly,C
AU - Ferguson,N
AU - Garske,T
DO - 10.4269/ajtmh.16-0401
EP - 1439
PY - 2016///
SN - 1476-1645
SP - 1435
TI - A meta-analysis of serological response associated with yellow fever vaccination
T2 - American Journal of Tropical Medicine and Hygiene
UR - http://dx.doi.org/10.4269/ajtmh.16-0401
UR - http://hdl.handle.net/10044/1/41386
VL - 95
ER -