Imperial College London
Alternate

Professor Theoni K. Georgiou

Faculty of Engineering, Department of Materials

Professor in Polymer Chemistry
 
 
 
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Contact

 

t.georgiou Website

 
 
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Location

 

RSM 1.05Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Constantinou:2018:10.1021/acs.macromol.8b01251,
author = {Constantinou, A and Sam-Soon, N and Carroll, D and Georgiou, T},
doi = {10.1021/acs.macromol.8b01251},
journal = {Macromolecules},
pages = {7019--7031},
title = {Thermoresponsive tetrablock terpolymers: effect of architecture and composition on Gelling behavior},
url = {http://dx.doi.org/10.1021/acs.macromol.8b01251},
volume = {51},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Thermoresponsive gels are an exciting class of materials with many bioapplications, like tissue engineering and drug delivery, but they are also used in formulation industry and 3-D printing. For these applications to be feasible, the gelation temperature must be tailored. Here, it is reported how the gelation temperature is affected and can be tailored by varying the architecture of tetrablock terpolymers. Specifically, 15 copolymers based on penta(ethylene glycol) methyl ether methacrylate (PEGMA, A block), n-butyl methacrylate (BuMA, B block), and the thermoresponsive 2-(dimethylamino)ethyl methacrylate (DMAEMA, C block) were synthesized using group transfer polymerization. Nine tetrablock copolymers of varying architectures, and one triblock copolymer for comparison, with constant molar mass and composition were fabricated. Specifically, the polymers that were investigated are (i) three polymers that contain two A blocks (ABCA, ABAC, and ACAB), (ii) three polymers that contain two B blocks (BACB, BABC, and ABCB), (iii) three polymers that contain two C blocks (CABC, CACB, and ACBC), and (iv) one ABC triblock terpolymer that was synthesized as the control polymer. Then, the five more promising architectures were chosen, and five more polymers with a slightly different composition were synthesized and characterized. Interestingly, it was demonstrated that the block position (architecture) has a significant effect on self-assembly (micelle formation), cloud point, and the rheological and gelling properties of the polymers with two of the tetrablocks showing promise as injectable gels. Specifically, the ACBC terpolymer with 20–30–50 w/w % PEGMA–BuMA–DMAEMA formed gels at at lower concentration but at higher temperatures than the ABC triblock copolymer that was synthesized as a control. On the other hand, the BABC terpolymer with 30–35–45 w/w % PEGMA–BuMA–DMAEMA formed gels at the same concentrations as the ABC triblock
AU  - Constantinou,A
AU  - Sam-Soon,N
AU  - Carroll,D
AU  - Georgiou,T
DO  - 10.1021/acs.macromol.8b01251
EP  - 7031
PY  - 2018///
SN  - 0024-9297
SP  - 7019
TI  - Thermoresponsive tetrablock terpolymers: effect of architecture and composition on Gelling behavior
T2  - Macromolecules
UR  - http://dx.doi.org/10.1021/acs.macromol.8b01251
UR  - https://pubs.acs.org/doi/10.1021/acs.macromol.8b01251
UR  - http://hdl.handle.net/10044/1/63744
VL  - 51
ER  -
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