Imperial College London
Alternate

Professor Theoni K. Georgiou

Faculty of Engineering, Department of Materials

Professor in Polymer Chemistry
 
 
 
//

Contact

 

t.georgiou Website

 
 
//

Location

 

RSM 1.05Royal School of MinesSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Lu:2016:10.1039/C5TB02378E,
author = {Lu, B and Tarn, MD and Pamme, N and Georgiou, TK},
doi = {10.1039/C5TB02378E},
journal = {Journal of Materials Chemistry B},
pages = {3086--3093},
title = {Microfluidically fabricated pH-responsive anionic amphiphilic microgels for drug release},
url = {http://dx.doi.org/10.1039/C5TB02378E},
volume = {4},
year = {2016}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Amphiphilic microgels of different composition based on the hydrophilic, pH-responsive acrylic acid (AA) and the hydrophobic, non-ionic n-butyl acrylate (BuA) were synthesised using a lab-on-a-chip device. Hydrophobic droplets were generated via a microfluidic platform that contained a protected form of AA, BuA, the hydrophobic crosslinker, ethylene glycol dimethacrylate (EGDMA), and a free radical initiator in an organic solvent. These hydrophobic droplets were photopolymerised within the microfluidic channels and subsequently hydrolysed, enabling an integrated platform for the rapid, automated, and in situ production of anionic amphiphilic microgels. The amphiphilic microgels did not feature the conventional core–shell structure but were instead based on random amphiphilic copolymers of AA and BuA and hydrophobic crosslinks. Due to their amphiphilic nature they were able to encapsulate and deliver both hydrophobic and hydrophilic moieties. The model drug delivery and the swelling ability of the microgels were influenced by the pH of the surrounding aqueous solution and the hydrophobic content of the microgels.
AU  - Lu,B
AU  - Tarn,MD
AU  - Pamme,N
AU  - Georgiou,TK
DO  - 10.1039/C5TB02378E
EP  - 3093
PY  - 2016///
SN  - 2050-7518
SP  - 3086
TI  - Microfluidically fabricated pH-responsive anionic amphiphilic microgels for drug release
T2  - Journal of Materials Chemistry B
UR  - http://dx.doi.org/10.1039/C5TB02378E
UR  - http://hdl.handle.net/10044/1/28835
VL  - 4
ER  -
Download