Imperial College London
Alternate

PROFESSOR H. TERENCE COOK

Faculty of Medicine, Department of Immunology and Inflammation

Emeritus Professor
 
 
 
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Contact

 

+44 (0)20 3313 2009t.h.cook

 
 
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Assistant

 

Miss Claudia Rocchi +44 (0)20 3313 2315

 
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Location

 

9N9Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Medjeral-Thomas:2021:10.1007/s00281-021-00882-9,
author = {Medjeral-Thomas, NR and Cook, HT and Pickering, MC},
doi = {10.1007/s00281-021-00882-9},
journal = {Springer Seminars in Immunopathology},
pages = {679--690},
title = {Complement activation in IgA nephropathy},
url = {http://dx.doi.org/10.1007/s00281-021-00882-9},
volume = {43},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - IgA nephropathy pathogenesis is incompletely understood, and this limits the development of disease-specific biomarkers and effective therapies. Evidence of complement activity in IgA nephropathy is well established. However, a growing body of research indicates complement activity is an important contributor to IgA nephropathy pathology. In particular, multiple associations have been identified between complement alternative, lectin and terminal pathway proteins and IgA nephropathy severity. Recently, we have also gained insight into possible mechanisms that could link glomerular IgA deposition, complement activity, glomerular inflammation and disease severity. Ongoing clinical trials of therapeutic complement inhibitors will provide insight into the importance of complement activity to IgA nephropathy pathogenesis. Further research into mechanisms of complement activity is essential to improving our understanding and management of patients with IgA nephropathy.
AU  - Medjeral-Thomas,NR
AU  - Cook,HT
AU  - Pickering,MC
DO  - 10.1007/s00281-021-00882-9
EP  - 690
PY  - 2021///
SN  - 1863-2297
SP  - 679
TI  - Complement activation in IgA nephropathy
T2  - Springer Seminars in Immunopathology
UR  - http://dx.doi.org/10.1007/s00281-021-00882-9
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000684083000002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://link.springer.com/article/10.1007%2Fs00281-021-00882-9
UR  - http://hdl.handle.net/10044/1/91317
VL  - 43
ER  -
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