Imperial College London
Alternate

PROFESSOR H. TERENCE COOK

Faculty of Medicine, Department of Immunology and Inflammation

Emeritus Professor
 
 
 
//

Contact

 

+44 (0)20 3313 2009t.h.cook

 
 
//

Assistant

 

Miss Claudia Rocchi +44 (0)20 3313 2315

 
//

Location

 

9N9Commonwealth BuildingHammersmith Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Cook:2018:10.1097/MNH.0000000000000412,
author = {Cook, HT},
doi = {10.1097/MNH.0000000000000412},
journal = {Current Opinion in Nephrology and Hypertension},
pages = {165--170},
title = {Evolving complexity of complement-related diseases: C3 glomerulopathy and atypical haemolytic uremic syndrome},
url = {http://dx.doi.org/10.1097/MNH.0000000000000412},
volume = {27},
year = {2018}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - PURPOSE OF REVIEW: The current review will discuss recent advances in our understanding of the pathology of C3 glomerulopathy and atypical haemolytic uremic syndrome (aHUS). RECENT FINDINGS: C3 glomerulopathy and aHUS are associated with abnormalities of control of the alternative pathway of complement. Recent articles have provided new insights into the classification of C3 glomerulopathy and its relationship to idiopathic immune complex-mediated glomerulonephritis. They suggest that there may be considerable overlap in pathogenesis between these entities and have indicated novel ways in which classification may be improved. There is increasing evidence that monoclonal gammopathy may cause C3 glomerulopathy or aHUS in older patients and emerging evidence that treatment of the underlying plasma cell clone may ameliorate the kidney disease. SUMMARY: Recent work has provided new insights into the causes of C3 glomerulopathy and aHUS, and the mechanism by which complement is dysregulated. This is of particular importance with the advent of new therapeutic agents which can specifically target different parts of the complement cascade.
AU  - Cook,HT
DO  - 10.1097/MNH.0000000000000412
EP  - 170
PY  - 2018///
SN  - 1535-3842
SP  - 165
TI  - Evolving complexity of complement-related diseases: C3 glomerulopathy and atypical haemolytic uremic syndrome
T2  - Current Opinion in Nephrology and Hypertension
UR  - http://dx.doi.org/10.1097/MNH.0000000000000412
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29517501
UR  - http://hdl.handle.net/10044/1/57985
VL  - 27
ER  -
Download