Imperial College London

DrThibautJombart

Faculty of MedicineSchool of Public Health

Lecturer in Genetic Analysis
 
 
 
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Contact

 

+44 (0)20 7594 3658t.jombart Website

 
 
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Location

 

UG11Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

63 results found

Bertranpetit E, Jombart T, Paradis E, Pena H, Dubey J, Su C, Mercier A, Devillard S, Ajzenberg Det al., 2017, Phylogeography of Toxoplasma gondii points to a South American origin, INFECTION GENETICS AND EVOLUTION, Vol: 48, Pages: 150-155, ISSN: 1567-1348

JOURNAL ARTICLE

Cori A, Donnelly CA, Dorigatti I, Ferguson NM, Fraser C, Garske T, Jombart T, Nedjati-Gilani G, Nouvellet P, Riley S, Van Kerkhove MD, Mills HL, Blake IMet al., 2017, Key data for outbreak evaluation: building on the Ebola experience, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 372, ISSN: 0962-8436

JOURNAL ARTICLE

Dupuis JR, Bremer FT, Jombart T, Sim SB, Geib SMet al., 2017, mvmapper: Interactive spatial mapping of genetic structures., Mol Ecol Resour

Characterizing genetic structure across geographic space is a fundamental challenge in population genetics. Multivariate statistical analyses are powerful tools for summarizing genetic variability, but geographic information and accompanying metadata are not always easily integrated into these methods in a user-friendly fashion. Here, we present a deployable Python-based web-tool, mvmapper, for visualizing and exploring results of multivariate analyses in geographic space. This tool can be used to map results of virtually any multivariate analysis of georeferenced data, and routines for exporting results from a number of standard methods have been integrated in the R package adegenet, including principal components analysis (PCA), spatial PCA, discriminant analysis of principal components, principal coordinates analysis, nonmetric dimensional scaling and correspondence analysis. mvmapper's greatest strength is facilitating dynamic and interactive exploration of the statistical and geographic frameworks side by side, a task that is difficult and time-consuming with currently available tools. Source code and deployment instructions, as well as a link to a hosted instance of mvmapper, can be found at https://popphylotools.github.io/mvMapper/.

JOURNAL ARTICLE

Garske T, Cori A, Ariyarajah A, Blake IM, Dorigatti I, Eckmanns T, Fraser C, Hinsley W, Jombart T, Mills HL, Nedjati-Gilani G, Newton E, Nouvellet P, Perkins D, Riley S, Schumacher D, Shah A, Van Kerkhove MD, Dye C, Ferguson NM, Donnelly CAet al., 2017, Heterogeneities in the case fatality ratio in the West African Ebola outbreak 2013-2016, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 372, ISSN: 0962-8436

JOURNAL ARTICLE

Inns T, Ashton PM, Herrera-Leon S, Lighthill J, Foulkes S, Jombart T, Rehman Y, Fox A, Dallman T, De Pinna E, Browning L, Coia JE, Edeghere O, Vivancos Ret al., 2017, Prospective use of whole genome sequencing (WGS) detected a multi-country outbreak of Salmonella Enteritidis, EPIDEMIOLOGY AND INFECTION, Vol: 145, Pages: 289-298, ISSN: 0950-2688

JOURNAL ARTICLE

Jombart T, Archer F, Schliep K, Kamvar Z, Harris R, Paradis E, Goudet J, Lapp Het al., 2017, apex: phylogenetics with multiple genes, MOLECULAR ECOLOGY RESOURCES, Vol: 17, Pages: 19-26, ISSN: 1755-098X

JOURNAL ARTICLE

Jombart T, Kendall M, Almagro-Garcia J, Colijn Cet al., 2017, treespace: Statistical exploration of landscapes of phylogenetic trees, MOLECULAR ECOLOGY RESOURCES, Vol: 17, Pages: 1385-1392, ISSN: 1755-098X

JOURNAL ARTICLE

Nouvellet P, Cori A, Garske T, Blake IM, Dorigatti I, Hinsley W, Jombart T, Mills HL, Nedjati-Gilani G, Van Kerkhove MD, Fraser C, Donnelly CA, Ferguson NM, Riley Set al., 2017, A simple approach to measure transmissibility and forecast incidence., Epidemics

Outbreaks of novel pathogens such as SARS, pandemic influenza and Ebola require substantial investments in reactive interventions, with consequent implementation plans sometimes revised on a weekly basis. Therefore, short-term forecasts of incidence are often of high priority. In light of the recent Ebola epidemic in West Africa, a forecasting exercise was convened by a network of infectious disease modellers. The challenge was to forecast unseen "future" simulated data for four different scenarios at five different time points. In a similar method to that used during the recent Ebola epidemic, we estimated current levels of transmissibility, over variable time-windows chosen in an ad hoc way. Current estimated transmissibility was then used to forecast near-future incidence. We performed well within the challenge and often produced accurate forecasts. A retrospective analysis showed that our subjective method for deciding on the window of time with which to estimate transmissibility often resulted in the optimal choice. However, when near-future trends deviated substantially from exponential patterns, the accuracy of our forecasts was reduced. This exercise highlights the urgent need for infectious disease modellers to develop more robust descriptions of processes - other than the widespread depletion of susceptible individuals - that produce non-exponential patterns of incidence.

JOURNAL ARTICLE

Paradis E, Gosselin T, Goudet J, Jombart T, Schliep Ket al., 2017, Linking genomics and population genetics with R, MOLECULAR ECOLOGY RESOURCES, Vol: 17, Pages: 54-66, ISSN: 1755-098X

JOURNAL ARTICLE

Paradis E, Gosselin T, Grunwald NJ, Jombart T, Manel S, Lapp Het al., 2017, Towards an integrated ecosystem of R packages for the analysis of population genetic data, MOLECULAR ECOLOGY RESOURCES, Vol: 17, Pages: 1-4, ISSN: 1755-098X

JOURNAL ARTICLE

Agua-Agum J, Allegranzi B, Ariyarajah A, Aylward RB, Blake IM, Barboza P, Bausch D, Brennan RJ, Clement P, Coffey P, Cori A, Donnelly CA, Dorigatti I, Drury P, Durski K, Dye C, Eckmanns T, Ferguson NM, Fraser C, Garcia E, Garske T, Gasasira A, Gurry C, Gutierrez GJ, Hamblion E, Hinsley W, Holden R, Holmes D, Hugonnet S, Jombart T, Kelley E, Santhana R, Mahmoud N, Mills HL, Mohamed Y, Musa E, Naidoo D, Nedjati-Gilani G, Newton E, Norton I, Nouvellet P, Perkins D, Perkins M, Riley S, Schumacher D, Shah A, Minh T, Varsaneux O, Van Kerkhove MDet al., 2016, After Ebola in West Africa - Unpredictable Risks, Preventable Epidemics, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 375, Pages: 587-596, ISSN: 0028-4793

JOURNAL ARTICLE

Agua-Agum J, Ariyarajah A, Aylward B, Bawo L, Bilivogui P, Blake IM, Brennan RJ, Cawthorne A, Cleary E, Clement P, Conteh R, Cori A, Dafae F, Dahl B, Dangou J-M, Diallo B, Donnelly CA, Dorigatti I, Dye C, Eckmanns T, Fallah M, Ferguson NM, Fiebig L, Fraser C, Garske T, Gonzalez L, Hamblion E, Hamid N, Hersey S, Hinsley W, Jambei A, Jombart T, Kargbo D, Keita S, Kinzer M, George FK, Godefroy B, Gutierrez G, Kannangarage N, Mills HL, Moller T, Meijers S, Mohamed Y, Morgan O, Nedjati-Gilani G, Newton E, Nouvellet P, Nyenswah T, Perea W, Perkins D, Riley S, Rodier G, Rondy M, Sagrado M, Savulescu C, Schafer IJ, Schumacher D, Seyler T, Shah A, Van Kerkhove MD, Wesseh CS, Yoti Zet al., 2016, Exposure Patterns Driving Ebola Transmission in West Africa: A Retrospective Observational Study, PLOS MEDICINE, Vol: 13, ISSN: 1549-1676

JOURNAL ARTICLE

Agua-Agum J, Ariyarajah A, Blake IM, Cori A, Donnelly CA, Dorigatti I, Dye C, Eck-Manns T, Ferguson NM, Fraser C, Garske T, Hinsley W, Jombart T, Mills HL, Nedjati-Gilani G, Newton E, Nouvellet P, Perkins D, Riley S, Schumacher D, Shah A, Thomas LJ, Van Kerkhove MDet al., 2016, Ebola Virus Disease among Male and Female Persons in West Africa, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 374, Pages: 96-98, ISSN: 0028-4793

JOURNAL ARTICLE

Cauchemez S, Nouvellet P, Cori A, Jombart T, Garske T, Clapham H, Moore S, Mills HL, Salje H, Collins C, Rodriquez-Barraquer I, Riley S, Truelove S, Algarni H, Alhakeem R, AlHarbi K, Turkistani A, Aguas RJ, Cummings DAT, Van Kerkhove MD, Donnelly CA, Lessler J, Fraser C, Al-Barrak A, Ferguson NMet al., 2016, Unraveling the drivers of MERS-CoV transmission, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 113, Pages: 9081-9086, ISSN: 0027-8424

JOURNAL ARTICLE

Clare FC, Halder JB, Daniel O, Bielby J, Semenov MA, Jombart T, Loyau A, Schmeller DS, Cunningham AA, Rowcliffe M, Garner TWJ, Bosch J, Fisher MCet al., 2016, Climate forcing of an emerging pathogenic fungus across a montane multi-host community, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 371, ISSN: 0962-8436

JOURNAL ARTICLE

Dallman T, Inns T, Jombart T, Ashton P, Loman N, Chatt C, Messelhaeusser U, Rabsch W, Simon S, Nikisins S, Bernard H, le Hello S, Jourdan da-Silva N, Kornschober C, Mossong J, Hawkey P, de Pinna E, Grant K, Cleary Pet al., 2016, Phylogenetic structure of European Salmonella Enteritidis outbreak correlates with national and international egg distribution network., Microb Genom, Vol: 2, ISSN: 2057-5858

Outbreaks of Salmonella Enteritidis have long been associated with contaminated poultry and eggs. In the summer of 2014 a large multi-national outbreak of Salmonella Enteritidis phage type 14b occurred with over 350 cases reported in the United Kingdom, Germany, Austria, France and Luxembourg. Egg supply network investigation and microbiological sampling identified the source to be a Bavarian egg producer. As part of the international investigation into the outbreak, over 400 isolates were sequenced including isolates from cases, implicated UK premises and eggs from the suspected source producer. We were able to show a clear statistical correlation between the topology of the UK egg distribution network and the phylogenetic network of outbreak isolates. This correlation can most plausibly be explained by different parts of the egg distribution network being supplied by eggs solely from independent premises of the Bavarian egg producer (Company X). Microbiological sampling from the source premises, traceback information and information on the interventions carried out at the egg production premises all supported this conclusion. The level of insight into the outbreak epidemiology provided by whole-genome sequencing (WGS) would not have been possible using traditional microbial typing methods.

JOURNAL ARTICLE

Finnie TJR, South A, Bento A, Sherrard-Smith E, Jombart Tet al., 2016, EpiJSON: A unified data-format for epidemiology, EPIDEMICS, Vol: 15, Pages: 20-26, ISSN: 1755-4365

JOURNAL ARTICLE

Karkey A, Jombart T, Walker AW, Thompson CN, Torres A, Dongol S, Nga TVT, Duy PT, Dung TTN, Phat VV, Singer AC, Parkhill J, Thwaites G, Basnyat B, Ferguson N, Baker Set al., 2016, The Ecological Dynamics of Fecal Contamination and Salmonella Typhi and Salmonella Paratyphi A in Municipal Kathmandu Drinking Water, PLOS NEGLECTED TROPICAL DISEASES, Vol: 10, ISSN: 1935-2735

JOURNAL ARTICLE

Lessler J, Salje H, Van Kerkhove MD, Ferguson NM, Cauchemez S, Rodriquez-Barraquer I, Hakeem R, Jombart T, Aguas R, Al-Barrak A, Cummings DATet al., 2016, Estimating the Severity and Subclinical Burden of Middle East Respiratory Syndrome Coronavirus Infection in the Kingdom of Saudi Arabia, AMERICAN JOURNAL OF EPIDEMIOLOGY, Vol: 183, Pages: 657-663, ISSN: 0002-9262

JOURNAL ARTICLE

Agua-Agum J, Ariyarajah A, Blake IM, Cori A, Donnelly CA, Dorigatti I, Dye C, Eckmanns T, Ferguson NM, Fowler RA, Fraser C, Garske T, Hinsley W, Jombart T, Mills HL, Murthy S, Nedjati-Gilani G, Nouvellet P, Pelletier L, Riley S, Schumacher D, Shah A, Van Kerkhove MDet al., 2015, Ebola Virus Disease among Children in West Africa, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 372, Pages: 1274-1277, ISSN: 0028-4793

JOURNAL ARTICLE

Hao CT, Karkey A, Duy PT, Boinett CJ, Cain AK, Ellington M, Baker KS, Dongol S, Thompson C, Harris SR, Jombart T, Tu LTP, Nhu TDH, Tuyen HT, Shretha S, Joshi S, Basnyat B, Thwaites G, Thomson NR, Rabaa MA, Baker Set al., 2015, A high-resolution genomic analysis of multidrug-resistant hospital outbreaks of Klebsiella pneumoniae, EMBO MOLECULAR MEDICINE, Vol: 7, Pages: 227-239, ISSN: 1757-4676

JOURNAL ARTICLE

Jombart T, Kendall ML, Almagro-Garcia J, Colijn Cet al., 2015, treespace

Statistical Exploration of Landscapes of Phylogenetic Trees

SOFTWARE

Mita T, Jombart T, 2015, Patterns and dynamics of genetic diversity in Plasmodium falciparum: What past human migrations tell us about malaria, PARASITOLOGY INTERNATIONAL, Vol: 64, Pages: 238-243, ISSN: 1383-5769

JOURNAL ARTICLE

Nhung NT, Cuong NV, Campbell J, Hoa NT, Bryant JE, Truc VNT, Kiet BT, Jombart T, Trung NV, Hien VB, Thwaites G, Baker S, Carrique-Mas Jet al., 2015, High Levels of Antimicrobial Resistance among Escherichia coli Isolates from Livestock Farms and Synanthropic Rats and Shrews in the Mekong Delta of Vietnam, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Vol: 81, Pages: 812-820, ISSN: 0099-2240

JOURNAL ARTICLE

Nouvellet P, Garske T, Mills HL, Nedjati-Gilani G, Hinsley W, Blake IM, Van Kerkhove MD, Cori A, Dorigatti I, Jombart T, Riley S, Fraser C, Donnelly CA, Ferguson NMet al., 2015, The role of rapid diagnostics in managing Ebola epidemics, NATURE, Vol: 528, Pages: S109-S116, ISSN: 0028-0836

JOURNAL ARTICLE

Tong SYC, Holden MTG, Nickerson EK, Cooper BS, Koeser CU, Cori A, Jombart T, Cauchemez S, Fraser C, Wuthiekanun V, Thaipadungpanit J, Hongsuwan M, Day NP, Limmathurotsakul D, Parkhill J, Peacock SJet al., 2015, Genome sequencing defines phylogeny and spread of methicillin-resistant Staphylococcus aureus in a high transmission setting, GENOME RESEARCH, Vol: 25, Pages: 111-118, ISSN: 1088-9051

JOURNAL ARTICLE

Weinert LA, Chaudhuri RR, Wang J, Peters SE, Corander J, Jombart T, Baig A, Howell KJ, Vehkala M, Vaelimaeki N, Harris D, Tran TBC, Nguyen VVC, Campbell J, Schultsz C, Parkhill J, Bentley SD, Langford PR, Rycroft AN, Wren BW, Farrar J, Baker S, Ngo TH, Holden MTG, Tucker AW, Maskell DJet al., 2015, Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis (vol 6, 6740, 2015), NATURE COMMUNICATIONS, Vol: 6, ISSN: 2041-1723

JOURNAL ARTICLE

Weinert LA, Chaudhuri RR, Wang J, Peters SE, Corander J, Jombart T, Baig A, Howell KJ, Vehkala M, Valimaki N, Harris D, Tran TBC, Nguyen VVC, Campbell J, Schultsz C, Parkhill J, Bentley SD, Langford PR, Rycroft AN, Wren BW, Farrar J, Baker S, Ngo TH, Holden MTG, Tucker AW, Maskell DJet al., 2015, Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis, NATURE COMMUNICATIONS, Vol: 6, ISSN: 2041-1723

JOURNAL ARTICLE

, 2015, West African Ebola Epidemic after One Year - Slowing but Not Yet under Control, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 372, Pages: 584-587, ISSN: 0028-4793

JOURNAL ARTICLE

Aylward B, Barboza P, Bawo L, Bertherat E, Bilivogui P, Blake I, Brennan R, Briand S, Chakauya JM, Chitala K, Conteh RM, Cori A, Croisier A, Dangou J-M, Diallo B, Donnelly CA, Dye C, Eckmanns T, Ferguson NM, Formenty P, Fuhrer C, Fukuda K, Garske T, Gasasira A, Gbanyan S, Graaff P, Heleze E, Jambai A, Jombart T, Kasolo F, Kadiobo AM, Keita S, Kertesz D, Kone M, Lane C, Markoff J, Massaquoi M, Mills H, Mulba JM, Musa E, Myhre J, Nasidi A, Nilles E, Nouvellet P, Nshimirimana D, Nuttall I, Nyenswah T, Olu O, Pendergast S, Perea W, Polonsky J, Riley S, Ronveaux O, Sakoba K, Krishnan RSG, Senga M, Shuaib F, Van Kerkhove MD, Vaz R, Kannangarage NW, Yoti Zet al., 2014, Ebola Virus Disease in West Africa - The First 9 Months of the Epidemic and Forward Projections, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 371, Pages: 1481-1495, ISSN: 0028-4793

JOURNAL ARTICLE

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