Imperial College London
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DrThomasMacdonald

Faculty of Natural Sciences, Department of Chemistry

Visiting Reseacher
 
 
 
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Contact

 

t.macdonald

 
 
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Location

 

Molecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Patrick:2019:10.1039/c8sc04895a,
author = {Patrick, PS and Bogart, LK and Macdonald, TJ and Southern, P and Powell, MJ and Zaw-Thin, M and Voelcker, NH and Parkin, IP and Pankhurst, QA and Lythgoe, MF and Kalber, TL and Bear, JC},
doi = {10.1039/c8sc04895a},
journal = {Chemical Science},
pages = {2592--2597},
title = {Surface radio-mineralisation mediates chelate-free radiolabelling of iron oxide nanoparticles},
url = {http://dx.doi.org/10.1039/c8sc04895a},
volume = {10},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - We introduce the concept of surface radio-mineralisation (SRM) to describe the chelate-free radiolabelling of iron-oxide and ferrite nanoparticles. We demonstrate the effectiveness of SRM with both 111In and 89Zr for bare, polymer-matrix multicore, and surface-functionalised magnetite/maghemite nanoparticles; and for bare Y3Fe5O12 nanoparticles. By analogy with geological mineralisation (the hydrothermal deposition of metals as minerals in ore bodies or lodes) we demonstrate that the heat-induced and aqueous SRM process deposits radiometal-oxides onto the nanoparticle or core surfaces, passing through the matrix or coating if present, without changing the size, structure, or magnetic properties of the nanoparticle or core. We show in a mouse model followed over 7 days that the SRM is sufficient to allow quantitative, non-invasive, prolonged, whole-body localisation of injected nanoparticles with nuclear imaging.
AU  - Patrick,PS
AU  - Bogart,LK
AU  - Macdonald,TJ
AU  - Southern,P
AU  - Powell,MJ
AU  - Zaw-Thin,M
AU  - Voelcker,NH
AU  - Parkin,IP
AU  - Pankhurst,QA
AU  - Lythgoe,MF
AU  - Kalber,TL
AU  - Bear,JC
DO  - 10.1039/c8sc04895a
EP  - 2597
PY  - 2019///
SN  - 2041-6520
SP  - 2592
TI  - Surface radio-mineralisation mediates chelate-free radiolabelling of iron oxide nanoparticles
T2  - Chemical Science
UR  - http://dx.doi.org/10.1039/c8sc04895a
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000459929800036&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://pubs.rsc.org/en/content/articlelanding/2019/SC/C8SC04895A#!divAbstract
UR  - http://hdl.handle.net/10044/1/78599
VL  - 10
ER  -
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