Imperial College London
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DrThomasMacdonald

Faculty of Natural Sciences, Department of Chemistry

Visiting Reseacher
 
 
 
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Contact

 

t.macdonald

 
 
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Location

 

Molecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{McInnes:2018:10.3390/nano8040205,
author = {McInnes, S and Macdonald, T and Parkin, I and Nann, T and Voelcker, N},
doi = {10.3390/nano8040205},
journal = {Nanomaterials},
pages = {205--205},
title = {Electrospun composites of polycaprolactone and porous silicon nanoparticles for the tunable delivery of small therapeutic molecules},
url = {http://dx.doi.org/10.3390/nano8040205},
volume = {8},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - This report describes the use of an electrospun composite of poly(ε-caprolactone) (PCL) fibers and porous silicon (pSi) nanoparticles (NPs) as an effective system for the tunable delivery of camptothecin (CPT), a small therapeutic molecule. Both materials are biodegradable, abundant, low-cost, and most importantly, have no known cytotoxic effects. The composites were treated with and without sodium hydroxide (NaOH) to investigate the wettability of the porous network for drug release and cell viability measurements. CPT release and subsequent cell viability was also investigated. We observed that the cell death rate was not only affected by the addition of our CPT carrier, pSi, but also by increasing the rate of dissolution via treatment with NaOH. This is the first example of loading pSi NPs as a therapeutics nanocarrier into electronspun PCL fibers and this system opens up new possibilities for the delivery of molecular therapeutics.
AU  - McInnes,S
AU  - Macdonald,T
AU  - Parkin,I
AU  - Nann,T
AU  - Voelcker,N
DO  - 10.3390/nano8040205
EP  - 205
PY  - 2018///
SN  - 2079-4991
SP  - 205
TI  - Electrospun composites of polycaprolactone and porous silicon nanoparticles for the tunable delivery of small therapeutic molecules
T2  - Nanomaterials
UR  - http://dx.doi.org/10.3390/nano8040205
UR  - https://www.mdpi.com/2079-4991/8/4/205
UR  - http://hdl.handle.net/10044/1/78585
VL  - 8
ER  -
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