Imperial College London
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ProfessorThomasMeier

Faculty of Natural Sciences, Department of Life Sciences

Visiting Professor
 
 
 
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Contact

 

t.meier Website

 
 
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Location

 

501Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hahn:2016:10.1016/j.molcel.2016.05.037,
author = {Hahn, A and Parey, K and Bublitz, M and Mills, DJ and Zickermann, V and Vonck, J and Kühlbrandt, W and Meier, T},
doi = {10.1016/j.molcel.2016.05.037},
journal = {Molecular Cell},
pages = {445--456},
title = {Structure of a Complete ATP Synthase Dimer Reveals the Molecular Basis of Inner Mitochondrial Membrane Morphology},
url = {http://dx.doi.org/10.1016/j.molcel.2016.05.037},
volume = {63},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - We determined the structure of a complete, dimeric F1Fo-ATP synthase from yeast Yarrowia lipolytica mitochondria by a combination of cryo-EM and X-ray crystallography. The final structure resolves 58 of the 60 dimer subunits. Horizontal helices of subunit a in Fo wrap around the c-ring rotor, and a total of six vertical helices assigned to subunits a, b, f, i, and 8 span the membrane. Subunit 8 (A6L in human) is an evolutionary derivative of the bacterial b subunit. On the lumenal membrane surface, subunit f establishes direct contact between the two monomers. Comparison with a cryo-EM map of the F1Fo monomer identifies subunits e and g at the lateral dimer interface. They do not form dimer contacts but enable dimer formation by inducing a strong membrane curvature of ∼100°. Our structure explains the structural basis of cristae formation in mitochondria, a landmark signature of eukaryotic cell morphology.
AU  - Hahn,A
AU  - Parey,K
AU  - Bublitz,M
AU  - Mills,DJ
AU  - Zickermann,V
AU  - Vonck,J
AU  - Kühlbrandt,W
AU  - Meier,T
DO  - 10.1016/j.molcel.2016.05.037
EP  - 456
PY  - 2016///
SN  - 1097-4164
SP  - 445
TI  - Structure of a Complete ATP Synthase Dimer Reveals the Molecular Basis of Inner Mitochondrial Membrane Morphology
T2  - Molecular Cell
UR  - http://dx.doi.org/10.1016/j.molcel.2016.05.037
UR  - http://hdl.handle.net/10044/1/33428
VL  - 63
ER  -
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