Imperial College London
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ProfessorThomasMeier

Faculty of Natural Sciences, Department of Life Sciences

Visiting Professor
 
 
 
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Contact

 

t.meier Website

 
 
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Location

 

501Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Eisel:2018:10.1002/1873-3468.12958,
author = {Eisel, B and Hartrampf, F and Meier, TK and Trauner, D},
doi = {10.1002/1873-3468.12958},
journal = {FEBS Letters},
pages = {343--355},
title = {Reversible optical control of F1Fo-ATP synthase using photoswitchable inhibitors},
url = {http://dx.doi.org/10.1002/1873-3468.12958},
volume = {592},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - F1Fo-ATP synthase is one of the best studied macromolecular machines in nature. It can be inhibited by a range of small molecules, which include the polyphenols resveratrol and piceatannol. Here, we introduce Photoswitchable Inhibitors of ATP Synthase, termed PIAS, which were synthetically derived from these polyphenols. They can be used to reversibly control the enzymatic activity of purified yeast Yarrowia lipolytica ATP synthase by light. Our experiments indicate that the PIAS described here bind to the same site in the ATP synthase F1 complex as the polyphenols in their trans form but they do not bind in their cis form. The new PIAS compounds could be useful tools for the optical precision control of ATP synthase in a variety of biochemical and biotechnological applications.
AU  - Eisel,B
AU  - Hartrampf,F
AU  - Meier,TK
AU  - Trauner,D
DO  - 10.1002/1873-3468.12958
EP  - 355
PY  - 2018///
SN  - 0014-5793
SP  - 343
TI  - Reversible optical control of F1Fo-ATP synthase using photoswitchable inhibitors
T2  - FEBS Letters
UR  - http://dx.doi.org/10.1002/1873-3468.12958
UR  - http://hdl.handle.net/10044/1/55725
VL  - 592
ER  -
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