Imperial College London


Faculty of EngineeringDepartment of Bioengineering

Senior Lecturer



t.ouldridge Website CV




4.04Royal School of MinesSouth Kensington Campus





I am a Royal Society University Research Fellow in the Bioengineering Department, where I lead the "Principles of Biomolecular Systems" group

My group probes the fundamental principles underlying complex biochemical systems through theoretical modelling, simulation and experiment. In particular, We focus on the interplay between the detailed biochemistry and the overall output of a process such as sensing, replication or self-assembly. We're inspired by natural systems, and aim to explore the possibilities of engineering artificial analogs. For more details, including open positions and recent work, please refer to our group page.

Our take on the most recent developments in the field can be found in the blog that we run.





Liu H, Hong F, Smith F, et al., 2021, Kinetics of RNA and RNA:DNA hybrid strand displacement, Acs Synthetic Biology, Vol:10, ISSN:2161-5063, Pages:3066-3073

Poulton JM, Ouldridge TE, 2021, Edge-effects dominate copying thermodynamics for finite-length molecular oligomers, New Journal of Physics, Vol:23, ISSN:1367-2630, Pages:1-14

Sengar A, Ouldridge TE, Henrich O, et al., 2021, A primer on the oxDNA model of DNA: When to use it, how to simulate it and how to interpret the results, Frontiers in Molecular Biosciences, Vol:8, ISSN:2296-889X, Pages:1-22

Plesa T, Stan G-B, Ouldridge TE, et al., 2021, Quasi-robust control of biochemical reaction networks via stochastic morphing., Journal of the Royal Society Interface, Vol:18, ISSN:1742-5662, Pages:1-14

Cabello-Garcia J, Bae W, Stan G-BV, et al., 2021, Handhold-mediated strand displacement: a nucleic acid based mechanism for generating far-from-equilibrium assemblies through templated reactions., Acs Nano, Vol:15, ISSN:1936-0851, Pages:3272-3283

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