Imperial College London
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DrThomasOuldridge

Faculty of Engineering, Department of Bioengineering

Reader in Biomolecular Systems
 
 
 
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Contact

 

t.ouldridge Website CV

 
 
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Location

 

4.04Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ouldridge:2021:10.1021/acs.nanolett.0c03629,
author = {Ouldridge, T and Stan, G-B and Bae, W},
doi = {10.1021/acs.nanolett.0c03629},
journal = {Nano Letters: a journal dedicated to nanoscience and nanotechnology},
pages = {265--271},
title = {In situ generation of RNA complexes for synthetic molecular strand displacement circuits in autonomous systems},
url = {http://dx.doi.org/10.1021/acs.nanolett.0c03629},
volume = {21},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Synthetic molecular circuits implementing DNA or RNA strand-displacement reactions can be used to build complex systems such as molecular computers and feedback control systems. Despite recent advances, application of nucleic acid-based circuits in vivo remains challenging due to a lack of efficient methods to produce their essential components, namely, multistranded complexes known as gates, in situ, i.e., in living cells or other autonomous systems. Here, we propose the use of naturally occurring self-cleaving ribozymes to cut a single-stranded RNA transcript into a gate complex of shorter strands, thereby opening new possibilities for the autonomous and continuous production of RNA strands in a stoichiometrically and structurally controlled way.
AU  - Ouldridge,T
AU  - Stan,G-B
AU  - Bae,W
DO  - 10.1021/acs.nanolett.0c03629
EP  - 271
PY  - 2021///
SN  - 1530-6984
SP  - 265
TI  - In situ generation of RNA complexes for synthetic molecular strand displacement circuits in autonomous systems
T2  - Nano Letters: a journal dedicated to nanoscience and nanotechnology
UR  - http://dx.doi.org/10.1021/acs.nanolett.0c03629
UR  - http://hdl.handle.net/10044/1/85880
VL  - 21
ER  -
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