Imperial College London
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Tony D. Southall

Faculty of Natural Sciences, Department of Life Sciences

Reader in Molecular Genetics
 
 
 
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Contact

 

+44 (0)20 7594 5338t.southall

 
 
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Location

 

407Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{McClure:2015:10.1016/bs.adgen.2015.06.003,
author = {McClure, CD and Southall, TD},
doi = {10.1016/bs.adgen.2015.06.003},
journal = {Advances in Genetics},
pages = {103--151},
title = {Getting Down to Specifics: Profiling Gene Expression and Protein-DNA Interactions in a Cell Type-Specific Manner.},
url = {http://dx.doi.org/10.1016/bs.adgen.2015.06.003},
volume = {91},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The majority of multicellular organisms are comprised of an extraordinary range of cell types, with different properties and gene expression profiles. Understanding what makes each cell type unique and how their individual characteristics are attributed are key questions for both developmental and neurobiologists alike. The brain is an excellent example of the cellular diversity expressed in the majority of eukaryotes. The mouse brain comprises of approximately 75million neurons varying in morphology, electrophysiology, and preferences for synaptic partners. A powerful process in beginning to pick apart the mechanisms that specify individual characteristics of the cell, as well as their fate, is to profile gene expression patterns, chromatin states, and transcriptional networks in a cell type-specific manner, i.e., only profiling the cells of interest in a particular tissue. Depending on the organism, the questions being investigated, and the material available, certain cell type-specific profiling methods are more suitable than others. This chapter reviews the approaches presently available for selecting and isolating specific cell types and evaluates their key features.
AU  - McClure,CD
AU  - Southall,TD
DO  - 10.1016/bs.adgen.2015.06.003
EP  - 151
PY  - 2015///
SN  - 0065-2660
SP  - 103
TI  - Getting Down to Specifics: Profiling Gene Expression and Protein-DNA Interactions in a Cell Type-Specific Manner.
T2  - Advances in Genetics
UR  - http://dx.doi.org/10.1016/bs.adgen.2015.06.003
UR  - http://hdl.handle.net/10044/1/26733
VL  - 91
ER  -
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