Imperial College London

Professor Terry Tetley

Faculty of MedicineNational Heart & Lung Institute

Consul (Non-Clinical) for the Faculty of Medicine
 
 
 
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Contact

 

+44 (0)20 7594 2984t.tetley Website

 
 
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Location

 

Cale StreetRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

168 results found

Calderon L, Han TT, McGilvery CM, Yang L, Subramaniam P, Lee K-B, Schwander S, Tetley TD, Georgopoulos PG, Ryan M, Porter AE, Smith R, Chung KF, Lioy PJ, Zhang J, Mainelis Get al., 2017, Release of airborne particles and Ag and Zn compounds from nanotechnology-enabled consumer sprays: Implications for inhalation exposure, ATMOSPHERIC ENVIRONMENT, Vol: 155, Pages: 85-96, ISSN: 1352-2310

JOURNAL ARTICLE

Chung KF, Seiffert J, Chen S, Theodorou IG, Goode AE, Leo BF, McGilvery CM, Hussain F, Wiegman C, Rossios C, Zhu J, Gong J, Tariq F, Yufit V, Monteith AJ, Hashimoto T, Skepper JN, Ryan MP, Zhang J, Tetley TD, Porter AEet al., 2017, Inactivation, Clearance, and Functional Effects of Lung-Instilled Short and Long Silver Nanowires in Rats, ACS NANO, Vol: 11, Pages: 2652-2664, ISSN: 1936-0851

JOURNAL ARTICLE

Conforti F, Davies ER, Calderwood CJ, Thatcher TH, Jones MG, Smart DE, Mahajan S, Alzetani A, Havelock T, Maher TM, Molyneaux PL, Thorley AJ, Tetley TD, Warner JA, Packham G, Ganesan A, Skipp PJ, Marshall BJ, Richeldi L, Sime PJ, O'Reilly KMA, Davies DEet al., 2017, The histone deacetylase inhibitor, romidepsin, as a potential treatment for pulmonary fibrosis, ONCOTARGET, Vol: 8, Pages: 48737-48754, ISSN: 1949-2553

JOURNAL ARTICLE

Mohamed NA, Davies RP, Lickiss PD, Ahmetaj-Shala B, Reed DM, Gashaw HH, Saleem H, Freeman GR, George PM, Wort SJ, Morales-Cano D, Barreira B, Tetley TD, Chester AH, Yacoub MH, Kirkby NS, Moreno L, Mitchell JAet al., 2017, Chemical and biological assessment of metal organic frameworks (MOFs) in pulmonary cells and in an acute in vivo model: relevance to pulmonary arterial hypertension therapy, PULMONARY CIRCULATION, Vol: 7, Pages: 643-653, ISSN: 2045-8932

JOURNAL ARTICLE

Robinson RK, Birrell MA, Adcock JJ, Wortley MA, Dubuis ED, Chen S, McGilvery CM, Hu S, Shaffer MSP, Bonvini SJ, Maher SA, Mudway IS, Porter AE, Carlsten C, Tetley TD, Belvisi MGet al., 2017, Mechanistic link between diesel exhaust particles and respiratory reflexes., J Allergy Clin Immunol

BACKGROUND: Diesel exhaust particles (DEPs) are a major component of particulate matter in Europe's largest cities, and epidemiologic evidence links exposure with respiratory symptoms and asthma exacerbations. Respiratory reflexes are responsible for symptoms and are regulated by vagal afferent nerves, which innervate the airway. It is not known how DEP exposure activates airway afferents to elicit symptoms, such as cough and bronchospasm. OBJECTIVE: We sought to identify the mechanisms involved in activation of airway sensory afferents by DEPs. METHODS: In this study we use in vitro and in vivo electrophysiologic techniques, including a unique model that assesses depolarization (a marker of sensory nerve activation) of human vagus. RESULTS: We demonstrate a direct interaction between DEP and airway C-fiber afferents. In anesthetized guinea pigs intratracheal administration of DEPs activated airway C-fibers. The organic extract (DEP-OE) and not the cleaned particles evoked depolarization of guinea pig and human vagus, and this was inhibited by a transient receptor potential ankyrin-1 antagonist and the antioxidant N-acetyl cysteine. Polycyclic aromatic hydrocarbons, major constituents of DEPs, were implicated in this process through activation of the aryl hydrocarbon receptor and subsequent mitochondrial reactive oxygen species production, which is known to activate transient receptor potential ankyrin-1 on nociceptive C-fibers. CONCLUSIONS: This study provides the first mechanistic insights into how exposure to urban air pollution leads to activation of guinea pig and human sensory nerves, which are responsible for respiratory symptoms. Mechanistic information will enable the development of appropriate therapeutic interventions and mitigation strategies for those susceptible subjects who are most at risk.

JOURNAL ARTICLE

Smyth E, Solomon A, Birrell MA, Smallwood MJ, Winyard PG, Tetley TD, Emerson Met al., 2017, Influence of inflammation and nitric oxide upon platelet aggregation following deposition of diesel exhaust particles in the airways, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 174, Pages: 2130-2139, ISSN: 0007-1188

JOURNAL ARTICLE

Thorley A, Ogger P, Legorburo-Schofield M, Tetley T, Wollin Let al., 2017, Nintedanib Effectively Inhibits Carbon Nanotube-Induced Fibrotic Responses In Human Alveolar Epithelial Cells, Fibroblasts And Pulmonary Microvascular Endothelial Cells, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X

CONFERENCE PAPER

Botelho DJ, Leo BF, Massa CB, Sarkar S, Tetley TD, Chung KF, Chen S, Ryan MP, Porter AE, Zhang J, Schwander SK, Gow AJet al., 2016, Low-dose AgNPs reduce lung mechanical function and innate immune defense in the absence of cellular toxicity, NANOTOXICOLOGY, Vol: 10, Pages: 118-127, ISSN: 1743-5390

JOURNAL ARTICLE

Chen S, Goode AE, Skepper JN, Thorley AJ, Seiffert JM, Chung KF, Tetley TD, Shaffer MSP, Ryan MP, Porter AEet al., 2016, Avoiding artefacts during electron microscopy of silver nanomaterials exposed to biological environments, JOURNAL OF MICROSCOPY, Vol: 261, Pages: 157-166, ISSN: 0022-2720

JOURNAL ARTICLE

Robinson RK, Birrell MA, Wortley MA, Dubuis ED, Chen S, McGilvery CM, Hu S, Bonvini SJ, Maher SA, Adcock JJ, Mudway I, Porter AE, Tetley TD, Belvisi MGet al., 2016, Diesel Activates Airway Sensory Nerves To Initiate Respiratory Symptoms, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X

CONFERENCE PAPER

Ruenraromgsak P, Chen S, Hu S, Melbourne J, Sweeney S, Thorley AJ, Skepper JN, Shaffer MSP, Tetley TD, Porter AEet al., 2016, Translocation of Functionalized Multi-Walled Carbon Nanotubes across Human Pulmonary Alveolar Epithelium: Dominant Role of Epithelial Type 1 Cells, ACS NANO, Vol: 10, Pages: 5070-5085, ISSN: 1936-0851

JOURNAL ARTICLE

Sarkar S, Carranza C, Theodorou I, Fen LB, Ellis T, Porter A, Ryan M, Zhang J, Tetley T, Schwander Set al., 2016, Impact of Silver and Carbon Nanoparticle Exposures on Macrophage Responses to Mycobacterium tuberculosis (M.tb), Annual Meeting of the American-Association-of-Immunologists (AAI), Publisher: AMER ASSOC IMMUNOLOGISTS, ISSN: 0022-1767

CONFERENCE PAPER

Seiffert J, Buckley A, Leo B, Martin NG, Zhu J, Dai R, Hussain F, Guo C, Warren J, Hodgson A, Gong J, Ryan MP, Zhang JJ, Porter A, Tetley TD, Gow A, Smith R, Chung KFet al., 2016, Pulmonary effects of inhalation of spark-generated silver nanoparticles in Brown-Norway and Sprague-Dawley rats, RESPIRATORY RESEARCH, Vol: 17, ISSN: 1465-993X

JOURNAL ARTICLE

Serrano-Mollar A, Gay-Jordi G, Guillamat-Prats R, Closa D, Hernandez-Gonzalez F, Marin P, Burgos F, Martorell J, Sanchez M, Arguis P, Soy D, Bayas JM, Ramirez J, Tetley TD, Molins L, Puig de la Bellacasa J, Rodriguez-Villar C, Rovira I, Jose Fibla J, Xaubet Aet al., 2016, Safety and Tolerability of Alveolar Type II Cell Transplantation in Idiopathic Pulmonary Fibrosis, CHEST, Vol: 150, Pages: 533-543, ISSN: 0012-3692

JOURNAL ARTICLE

Sweeney S, Hu S, Ruenraroengsak P, Chen S, Gow A, Schwander S, Zhang JJ, Chung KF, Ryan MP, Porter AE, Shaffer MS, Tetley TDet al., 2016, Carboxylation of multiwalled carbon nanotubes reduces their toxicity in primary human alveolar macrophages, ENVIRONMENTAL SCIENCE-NANO, Vol: 3, Pages: 1340-1350, ISSN: 2051-8153

JOURNAL ARTICLE

Sweeney S, Leo BF, Chen S, Abraham-Thomas N, Thorley AJ, Gow A, Schwander S, Zhang JJ, Shaffer MSP, Chung KF, Ryan MP, Porter AE, Tetley TDet al., 2016, Pulmonary surfactant mitigates silver nanoparticle toxicity in human alveolar type-I-like epithelial cells, COLLOIDS AND SURFACES B-BIOINTERFACES, Vol: 145, Pages: 167-175, ISSN: 0927-7765

JOURNAL ARTICLE

Theodorou IG, Ruenraroengsak P, Gow A, Schwander S, Zhang JJ, Chung KF, Tetley TD, Ryan MP, Porter AEet al., 2016, Effect of pulmonary surfactant on the dissolution, stability and uptake of zinc oxide nanowires by human respiratory epithelial cells, NANOTOXICOLOGY, Vol: 10, Pages: 1351-1362, ISSN: 1743-5390

JOURNAL ARTICLE

Zhang JJ, Lee K-B, He L, Seiffert J, Subramaniam P, Yang L, Chen S, Maguire P, Mainelis G, Schwander S, Tetley T, Porter A, Ryan M, Shaffer M, Hu S, Gong J, Chung KFet al., 2016, Effects of a nanoceria fuel additive on the physicochemical properties of diesel exhaust particles, ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS, Vol: 18, Pages: 1333-1342, ISSN: 2050-7887

JOURNAL ARTICLE

Botelho D, Shaffer M, Porter A, Chung KF, Tetley T, Zhang J, Gow Aet al., 2015, Lung Lining Interaction Determines the Fate of Multi-Walled Carbon Nanotubes (MWCNTs) in vivo, Experimental Biology Meeting, Publisher: FEDERATION AMER SOC EXP BIOL, ISSN: 0892-6638

CONFERENCE PAPER

Cryer AM, Ruenraroengsak P, Tetley TD, Thorley AJet al., 2015, SYNTHESIS OF GOLD-BASED NANOMEDICINES TO TREAT NON-SMALL CELL LUNG CANCER, Winter Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A58-A59, ISSN: 0040-6376

CONFERENCE PAPER

Marchetti M, Shaffer MSP, Zambianchi M, Chen S, Superti F, Schwander S, Gow A, Zhang JJ, Chung KF, Ryan MP, Porter AE, Tetley TDet al., 2015, Adsorption of surfactant protein D from human respiratory secretions by carbon nanotubes and polystyrene nanoparticles depends on nanomaterial surface modification and size, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 370, ISSN: 0962-8436

JOURNAL ARTICLE

McKenzie Z, Kendall M, Mackay R-M, Tetley TD, Morgan C, Griffiths M, Clark HW, Madsen Jet al., 2015, Nanoparticles modulate surfactant protein A and D mediated protection against influenza A infection in vitro, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 370, ISSN: 0962-8436

JOURNAL ARTICLE

Melbourne J, Clancy A, Seiffert J, Skepper J, Tetley TD, Shaffer MS, Porter Aet al., 2015, An investigation of the carbon nanotube - Lipid interface and its impact upon pulmonary surfactant lipid function., Biomaterials, Vol: 55, Pages: 24-32, ISSN: 1878-5905

Multiwalled carbon nanotubes (MWCNTs) are now synthesized on a large scale, increasing the risk of occupational inhalation. However, little is known of the MWCNT-pulmonary surfactant (PS) interface and its effect on PS functionality. The Langmuir-Blodgett trough was used to evaluate the impact of MWCNTs on fundamental properties of PS lipids which influence PS function, i.e. compression resistance and maximum obtainable pressure. Changes were found to be MWCNT length-dependent. 'Short' MWCNTs (1.1 μm, SD = 0.61) penetrated the lipid film, reducing the maximum interfacial film pressure by 10 mN/m (14%) in dipalmitoylphosphatidylcholine (DPPC) and PS, at an interfacial MWCNT-PS lipid mass ratio range of 50:1 to 1:1. 'Long' commercial MWCNTs (2.1 μm, SD = 1.2) caused compression resistance at the same mass loadings. 'Very long' MWCNTs (35 μm, SD = 19) sequestered DPPC and were squeezed out of the DPPC film. High resolution transmission electron microscopy revealed that all MWCNT morphologies formed DPPC coronas with ordered arrangements. These results provide insight into how nanoparticle aspect ratio affects the interaction mechanisms with PS, in its near-native state at the air-water interface.

JOURNAL ARTICLE

Mukherjee D, Porter A, Ryan M, Schwander S, Chung KF, Tetley T, Zhang J, Georgopoulos Pet al., 2015, Modeling In Vivo Interactions of Engineered Nanoparticles in the Pulmonary Alveolar Lining Fluid, NANOMATERIALS, Vol: 5, Pages: 1223-1249, ISSN: 2079-4991

JOURNAL ARTICLE

Nyga A, Hart A, Tetley TD, 2015, Importance of the HIF pathway in cobalt nanoparticle-induced cytotoxicity and inflammation in human macrophages, NANOTOXICOLOGY, Vol: 9, Pages: 905-917, ISSN: 1743-5390

JOURNAL ARTICLE

Sarkar S, Leo BF, Carranza C, Chen S, Rivas-Santiago C, Porter AE, Ryan MP, Gow A, Chung KF, Tetley TD, Zhang JJ, Georgopoulos PG, Ohman-Strickland PA, Schwander Set al., 2015, Modulation of Human Macrophage Responses to Mycobacterium tuberculosis by Silver Nanoparticles of Different Size and Surface Modification, PLOS ONE, Vol: 10, ISSN: 1932-6203

JOURNAL ARTICLE

Seiffert J, Hussain F, Wiegman C, Li F, Bey L, Baker W, Porter A, Ryan MP, Chang Y, Gow A, Zhang J, Zhu J, Tetley TD, Chung KFet al., 2015, Pulmonary Toxicity of Instilled Silver Nanoparticles: Influence of Size, Coating and Rat Strain, PLOS ONE, Vol: 10, ISSN: 1932-6203

JOURNAL ARTICLE

Smyth E, Solomon A, Vydyanath A, Luther PK, Pitchford S, Tetley TD, Emerson Met al., 2015, Induction and enhancement of platelet aggregation in vitro and in vivo by model polystyrene nanoparticles, NANOTOXICOLOGY, Vol: 9, Pages: 356-364, ISSN: 1743-5390

JOURNAL ARTICLE

Sweeney S, Berhanu D, Ruenraroengsak P, Thorley AJ, Valsami-Jones E, Tetley TDet al., 2015, Nano-titanium dioxide bioreactivity with human alveolar type-I-like epithelial cells: Investigating crystalline phase as a critical determinant, NANOTOXICOLOGY, Vol: 9, Pages: 482-492, ISSN: 1743-5390

JOURNAL ARTICLE

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