Imperial College London
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ProfessorThomasChurcher

Faculty of Medicine, School of Public Health

Professor of Infectious Disease Dynamics
 
 
 
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Contact

 

thomas.churcher

 
 
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Location

 

G35Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bompard:2020:10.1016/j.ijpara.2020.05.012,
author = {Bompard, A and Da, DF and Yerbanga, SR and Morlais, I and Awono-Ambéné, PH and Dabiré, RK and Bosco, Ouédraogo J and Lefèvre, T and Churcher, TS and Cohuet, A},
doi = {10.1016/j.ijpara.2020.05.012},
journal = {International Journal for Parasitology},
pages = {985--996},
title = {High Plasmodium infection intensity in naturally infected malaria vectors in Africa},
url = {http://dx.doi.org/10.1016/j.ijpara.2020.05.012},
volume = {50},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The population dynamics of human to mosquito malaria transmission in the field has important implications for the genetics, epidemiology and control of malaria. The number of oocysts in oocyst-positive mosquitoes developing from a single, naturally acquired infectious blood meal (herein referred to as a single-feed infection load) greatly influences the efficacy of transmission blocking interventions but still remains poorly documented. During a year-long analysis of malaria parasite transmission in Burkina Faso we caught and dissected wild malaria vectors to assess Plasmodium oocyst prevalence and load (the number of oocysts counted in mosquitoes with detectable oocysts) and the prevalence of salivary gland sporozoites. This was compared with malaria endemicity in the human population, assessed in cross-sectional surveys. Data were analyzed using a novel transmission mathematical model to estimate the per bite transmission probability and the average single-feed infection load for each location. The observed oocyst load and the estimated single-feed infection load in naturally infected mosquitoes were substantially higher than previous estimates (means ranging from 3.2 to 24.5 according to seasons and locations) and indicate a strong positive association between the single-feed infection load and parasite prevalence in humans. This work suggests that highly infected mosquitoes are not rare in the field and might have a greater influence on the epidemiology and genetics of the parasite, and on the efficacy of novel transmission blocking interventions.
AU  - Bompard,A
AU  - Da,DF
AU  - Yerbanga,SR
AU  - Morlais,I
AU  - Awono-Ambéné,PH
AU  - Dabiré,RK
AU  - Bosco,Ouédraogo J
AU  - Lefèvre,T
AU  - Churcher,TS
AU  - Cohuet,A
DO  - 10.1016/j.ijpara.2020.05.012
EP  - 996
PY  - 2020///
SN  - 0020-7519
SP  - 985
TI  - High Plasmodium infection intensity in naturally infected malaria vectors in Africa
T2  - International Journal for Parasitology
UR  - http://dx.doi.org/10.1016/j.ijpara.2020.05.012
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32681932
UR  - https://www.sciencedirect.com/science/article/pii/S002075192030182X?via%3Dihub
UR  - http://hdl.handle.net/10044/1/81308
VL  - 50
ER  -
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