Imperial College London
Portrait Picture

ProfessorThomasChurcher

Faculty of Medicine, School of Public Health

Professor of Infectious Disease Dynamics
 
 
 
//

Contact

 

thomas.churcher

 
 
//

Location

 

G35Medical SchoolSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Churcher:2017:10.1371/journal.pmed.1002450,
author = {Churcher, T and Chanda, E and Coetzee, M and Davenport, M and Diabate, A and Djimde, A and Dondorp, AM and Donnelly, M and Hemingway, J and Huijben, S and Kachur, P and Kamau, E and Knox, TB and Lobo, NF and Mayor, A and Menard, D and Paaijmans, K and Picot, S and Plowe, CV and Price, R and Rabinovich, R and Ranson, H and Reddy, M and Rees, S and Ringwald, P and Rabinovich, R and Sibley, CH and Simard, F and Wondji, CS},
doi = {10.1371/journal.pmed.1002450},
journal = {PLoS Medicine},
title = {malERA: An updated research agenda for insecticide and drug resistance in malaria elimination and eradication},
url = {http://dx.doi.org/10.1371/journal.pmed.1002450},
volume = {14},
year = {2017}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Resistance to first-line treatments for Plasmodium falciparum malaria and the insecticidesused for Anopheles vector control are threatening malaria elimination efforts. Suboptimalresponses to drugs and insecticides are both spreading geographically and emerging independentlyand are being seen at increasing intensities. Whilst resistance is unavoidable, itseffects can be mitigated through resistance management practices, such as exposing theparasite or vector to more than one selective agent. Resistance contributed to the failure ofthe 20th century Global Malaria Eradication Programme, and yet the global response to thisissue continues to be slow and poorly coordinated—too often, too little, too late. The MalariaEradication Research Agenda (malERA) Refresh process convened a panel on resistanceof both insecticides and antimalarial drugs. This paper outlines developments in the fieldover the past 5 years, highlights gaps in knowledge, and proposes a research agendafocused on managing resistance. A deeper understanding of the complex biological processesinvolved and how resistance is selected is needed, together with evidence of its publichealth impact. Resistance management will require improved use of entomological andparasitological data in decision making, and optimisation of the useful life of new and existingproducts through careful implementation, combination, and evaluation. A proactive, collaborativeapproach is needed from basic science and the development of new tools toprogramme and policy interventions that will ensure that the armamentarium of drugs andinsecticides is sufficient to deal with the challenges of malaria control and its elimination.
AU  - Churcher,T
AU  - Chanda,E
AU  - Coetzee,M
AU  - Davenport,M
AU  - Diabate,A
AU  - Djimde,A
AU  - Dondorp,AM
AU  - Donnelly,M
AU  - Hemingway,J
AU  - Huijben,S
AU  - Kachur,P
AU  - Kamau,E
AU  - Knox,TB
AU  - Lobo,NF
AU  - Mayor,A
AU  - Menard,D
AU  - Paaijmans,K
AU  - Picot,S
AU  - Plowe,CV
AU  - Price,R
AU  - Rabinovich,R
AU  - Ranson,H
AU  - Reddy,M
AU  - Rees,S
AU  - Ringwald,P
AU  - Rabinovich,R
AU  - Sibley,CH
AU  - Simard,F
AU  - Wondji,CS
DO  - 10.1371/journal.pmed.1002450
PY  - 2017///
SN  - 1549-1277
TI  - malERA: An updated research agenda for insecticide and drug resistance in malaria elimination and eradication
T2  - PLoS Medicine
UR  - http://dx.doi.org/10.1371/journal.pmed.1002450
UR  - http://hdl.handle.net/10044/1/55448
VL  - 14
ER  -
Download